Patents Assigned to U.S. Department of Health and Human Services
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Patent number: 10633370Abstract: The present invention is directed to methods of inhibiting p97 and compounds and compositions useful in such methods. Diseases and conditions the can be treated with the compounds and compositions of the invention include, but are not limited to, cancer and neurodegenerative disorders susceptible to treatment by inhibition of p97.Type: GrantFiled: October 20, 2016Date of Patent: April 28, 2020Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, National Institutes of Health, A Component of the U.S. Department of Health and Human Services, The Regents of the University of CaliforniaInventors: Donna M. Huryn, Peter Wipf, Matthew G. LaPorte, Raffaele Colombo, Marina Kovaliov, Chaemin Lim, Celeste Natalie Alverez, Zhizhou Yue, Lalith Palitha Samankumara, Alexander Julian Chatterley, Yongzhao Yan, Mary Liang, Neal J. Green, Eric T. Baldwin, William J. Moore, Michelle Arkin, R. Jeffrey Neitz, Kean-Hooi Ang, Clifford Bryant, Stacie Bulfer
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Publication number: 20180319778Abstract: The present invention is directed to methods of inhibiting p97 and compounds and compositions useful in such methods. Diseases and conditions the can be treated with the compounds and compositions of the invention include, but are not limited to, cancer and neurodegenerative disorders susceptible to treatment by inhibition of p97.Type: ApplicationFiled: October 20, 2016Publication date: November 8, 2018Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, National Institute of Health, A Component of the U.S Department of Health and Human Services, The Regents of the University of CaliforniaInventors: Donna M. HURYN, Peter Wipf, Matthew G. LaPorte, Raffaele Colombo, Marina Kovaliov, Chaemin Lim, Celeste Natalie Alverez, Zhizhou Yue, Lalith Palitha Samankumara, Alexander Julian Chatterley, Yongzhao Yan, Mary Liang, Neal J. Green, Eric T. Baldwin, William J. Moore, Michelle Arkin, R. Jeffrey Neilz, Kean-Hooi Ang, Cliffford Bryant, Stacie Bulfer
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Patent number: 10121645Abstract: Provided herein are capillaries for use in an electrophoretic separations. The capillaries can comprise an elongated tubular wall defining a path for fluid flow from an inlet to a tapered outlet; and a decoupler junction positioned within the elongated tubular wall upstream of the tapered outlet. The decoupler junction can comprise a plurality of microchannels penetrating through the elongated tubular wall and an ion-permeable polymer coating the plurality of microchannels. Also provided are sheathless interfaces for coupling capillary electrophoresis (CE) with mass spectrometry that employ these capillaries.Type: GrantFiled: December 5, 2017Date of Patent: November 6, 2018Assignee: National Institutes of Health (NIH) U.S. Department of Health and Human Services (DHHS), U.S. Government NIH Division of Extramural Inventions and Technology Resources (DEITR)Inventors: Craig E. Lunte, Ryan Tyler Johnson, Nhan To, Susan M. Lunte, Damon Osbourn
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Patent number: 10000465Abstract: The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 and substituted derivatives thereof.Type: GrantFiled: March 19, 2015Date of Patent: June 19, 2018Assignees: Mycovia Pharmaceuticals, Inc., U.S. Department of Health and Human ServicesInventors: William J. Hoekstra, Christopher M. Yates, Mark Behnke, Asaf Alimardanov, Scott A. David, Douglas Franklin Fry
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Patent number: 9649343Abstract: The present invention provides compositions that include an extract of human feces, and methods for using such compositions, including methods for replacing or supplementing or modifying a subject's colon microbiota, and methods for treating a disease, pathological condition, and/or iatrogenic condition of the colon.Type: GrantFiled: September 9, 2016Date of Patent: May 16, 2017Assignee: National Institutes of Health (NIH); U.S. Department of Health and Human Services (DHHS); The United States of America, NIH Division of Extramural Inventions and Tehnology Resources (DEITR)Inventors: Michael J. Sadowsky, Alexander Khoruts, Alexa R. Weingarden, Matthew J. Hamilton
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Patent number: 8463366Abstract: A medical instrument that comprises: a first-stage optic responsive to a tissue surface of a patient; a spectral separator optically responsive to the first stage optic and having a control input; an imaging sensor optically responsive to the spectral separator and having an image data output; and a diagnostic processor having an image acquisition interface with an input responsive to the imaging sensor and a filter control interface having a control output provided to the control input of the spectral separator.Type: GrantFiled: November 22, 2011Date of Patent: June 11, 2013Assignees: Hypermed Imaging, Inc., U.S. Department of Health and Human ServicesInventors: Jenny E. Freeman, Edgar N. Lewis
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Publication number: 20120215112Abstract: A medical instrument that comprises: a first-stage optic responsive to a tissue surface of a patient; a spectral separator optically responsive to the first stage optic and having a control input; an imaging sensor optically responsive to the spectral separator and having an image data output; and a diagnostic processor having an image acquisition interface with an input responsive to the imaging sensor and a filter control interface having a control output provided to the control input of the spectral separator.Type: ApplicationFiled: November 22, 2011Publication date: August 23, 2012Applicants: U.S. Department of Health and Human Services, Hypermed Imaging, Inc.Inventors: Edgar N. Lewis, Jenny E. Freeman
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Publication number: 20120157410Abstract: The invention relates to compositions, conjugates and methods comprising pyridazine compounds and cholinesterase inhibitors for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.Type: ApplicationFiled: February 17, 2012Publication date: June 21, 2012Applicants: U.S. Government, National Institute of Health (NIH), U.S. Department of Health and Human Services (DHSS),Inventors: D. Martin WATTERSON, Linda VAN ELDIK, Wenhui HU
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Publication number: 20120108903Abstract: Balloon probes, adapted for use in endoscopy and other medical procedures, are useful to obtain spectroscopic information reflected or emitted from a tissue of interest in the infrared spectral region. The information collected by the probe is useful in the diagnosis and treatment of disease. The invention also relates to methods utilizing these probes to analyze a surface of interest, in a minimally invasive manner, in connection with the diagnosis and treatment of disease.Type: ApplicationFiled: August 31, 2011Publication date: May 3, 2012Applicants: U.S. Department of Health and Human Services, Hypermed Imaging, Inc.Inventors: Jenny E. Freeman, Charles R. Lambert, Michael J. Hopmeier, Edgar N. Lewis
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Publication number: 20060018927Abstract: Recombinant respiratory syncytial virus (RSV) having the position of genes shifted within the genome or antigenome of the recombinant virus are infectious and attenuated in humans and other mammals. Gene shifted RSV are constructed by insertion, deletion or rearrangement of genes or genome segments within the recombinant genome or antigenome and are useful in vaccine formulations for eliciting an anti-RSV immune response. Also provided are isolated polynucleotide molecules and vectors incorporating a recombinant RSV genome or antigenome wherein a gene or gene segment is shifted to a more promoter-proximal or promoter-distal position within the genome or antigenome compared to a wild type position of the gene in the RSV gene map. Shifting the position of genes in this manner provides for a selected increase or decrease in expression of the gene, depending on the nature and degree of the positional shift.Type: ApplicationFiled: February 8, 2005Publication date: January 26, 2006Applicant: The Govt. of the U.S.A, Department of Health and Human Services National Institutes of HealthInventors: Christine Krempl, Peter Collins, Brian Murphy, Ursula Buchholz, Stephen Whitehead