Patents Assigned to U.S. Dept. of Veterans Affairs
  • Patent number: 11820753
    Abstract: Biochemically active PASTA kinase inhibitors which exploit subtle structural differences between human kinases and bacterial PASTA kinases to improve specificity and inhibitor activity.
    Type: Grant
    Filed: February 10, 2021
    Date of Patent: November 21, 2023
    Assignees: Wisconsin Alumni Research Foundation, U.S. Dept. of Veterans Affairs
    Inventors: Robert Todd Striker, Nathan Joseph Wlodarchak, John Bruce Feltenberger, Jennifer Golden
  • Patent number: 9114133
    Abstract: A method of treating, preventing, reversing, or ameliorating diastolic dysfunction includes reducing S-glutathionylated myosin binding protein-C (MyBP-C) level by administering to a host in need thereof a therapeutically effective amount of tetrahydrobiopterin (BH4).
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: August 25, 2015
    Inventor: Samuel C. Dudley, Jr.
  • Publication number: 20120213886
    Abstract: The invention provides for a diet that significantly reduces the glycohemoglobin levels in individuals with type 2 diabetes. A diet plan can be provided to an individual in the form of cards and/or pages with an appropriate meal plan, food items and/or pre-packaged meals, or in an electronic medium for the individuals to use to develop appropriate meal plans. The diet comprises food items having a nutritional composition that consists essentially of 30% protein, 50% fats, and 20% carbohydrates, or food items having a nutritional composition that consists essentially of 30% protein, 40% fats, and 30% carbohydrates, and is consumed for a period of three weeks to one year.
    Type: Application
    Filed: February 21, 2012
    Publication date: August 23, 2012
    Applicants: U.S. Dept. of Veterans Affairs, Regents of the Univ. of Minnesota
    Inventors: Mary C. Gannon, Frank Q. Nuttall
  • Publication number: 20090105181
    Abstract: The present invention relates to the use of oxidized nicotinamide adenine dinucleotide (NAD+) or of its reduced form, NADH, as sodium channel modulators. The present invention also relates to the use of compositions containing NAD+ or NADH to treat conditions associated with sodium channel current, such as arrhythmia. NAD+ is found to increase sodium channel current, while NADH is found to decrease sodium channel current. Thus, conditions that are associated with decreased sodium channel current can be treated with NAD+, while conditions that is associated with increased sodium channel current can be treated with NADH.
    Type: Application
    Filed: October 17, 2008
    Publication date: April 23, 2009
    Applicant: The U.S.A Dept. of Veterans Affairs Technology Transfer Program Office of Research & Development
    Inventor: Samuel C. Dudley, JR.
  • Publication number: 20070249734
    Abstract: A method, composition and kit for detecting the presence of a phospholipid, such as phosphatidylserine, on a cell membrane is provided. A binding agent including lactadherin, a fragment of lactadherin, a functional equivalent of lactadherin, or a functional equivalent of a fragment of lactadherin, is used to detect the presence of any phospholipid.
    Type: Application
    Filed: June 30, 2004
    Publication date: October 25, 2007
    Inventors: Gary Gilbert, Jialan Shi, Christian Heegaard, Jan Rasmussen
  • Patent number: 6908899
    Abstract: A synthetic tetrapeptide having an amino acide sequence, Glycine-Proline-Arginine-Proline (GPRP) has pro-inflammatory effects on human fibroblastic cells, including synovial cells. An amide analog of GPRP is ineffective in inducing, or effective in causing a loss of, pro-inflammatory effects.
    Type: Grant
    Filed: August 17, 2001
    Date of Patent: June 21, 2005
    Assignee: U.S. Dept. of Veterans Affairs
    Inventor: Theresa H. Smith