Abstract: Biochemically active PASTA kinase inhibitors which exploit subtle structural differences between human kinases and bacterial PASTA kinases to improve specificity and inhibitor activity.
Type:
Grant
Filed:
February 10, 2021
Date of Patent:
November 21, 2023
Assignees:
Wisconsin Alumni Research Foundation, U.S. Dept. of Veterans Affairs
Inventors:
Robert Todd Striker, Nathan Joseph Wlodarchak, John Bruce Feltenberger, Jennifer Golden
Abstract: A method of treating, preventing, reversing, or ameliorating diastolic dysfunction includes reducing S-glutathionylated myosin binding protein-C (MyBP-C) level by administering to a host in need thereof a therapeutically effective amount of tetrahydrobiopterin (BH4).
Type:
Grant
Filed:
October 24, 2012
Date of Patent:
August 25, 2015
Assignees:
U.S. DEPT. OF VETERANS AFFAIRS, THE BOARD OF TRUSTEES OF THE UNIV. OF ILLINOIS
Abstract: The invention provides for a diet that significantly reduces the glycohemoglobin levels in individuals with type 2 diabetes. A diet plan can be provided to an individual in the form of cards and/or pages with an appropriate meal plan, food items and/or pre-packaged meals, or in an electronic medium for the individuals to use to develop appropriate meal plans. The diet comprises food items having a nutritional composition that consists essentially of 30% protein, 50% fats, and 20% carbohydrates, or food items having a nutritional composition that consists essentially of 30% protein, 40% fats, and 30% carbohydrates, and is consumed for a period of three weeks to one year.
Type:
Application
Filed:
February 21, 2012
Publication date:
August 23, 2012
Applicants:
U.S. Dept. of Veterans Affairs, Regents of the Univ. of Minnesota
Abstract: The present invention relates to the use of oxidized nicotinamide adenine dinucleotide (NAD+) or of its reduced form, NADH, as sodium channel modulators. The present invention also relates to the use of compositions containing NAD+ or NADH to treat conditions associated with sodium channel current, such as arrhythmia. NAD+ is found to increase sodium channel current, while NADH is found to decrease sodium channel current. Thus, conditions that are associated with decreased sodium channel current can be treated with NAD+, while conditions that is associated with increased sodium channel current can be treated with NADH.
Type:
Application
Filed:
October 17, 2008
Publication date:
April 23, 2009
Applicant:
The U.S.A Dept. of Veterans Affairs Technology Transfer Program Office of Research & Development
Abstract: A method, composition and kit for detecting the presence of a phospholipid, such as phosphatidylserine, on a cell membrane is provided. A binding agent including lactadherin, a fragment of lactadherin, a functional equivalent of lactadherin, or a functional equivalent of a fragment of lactadherin, is used to detect the presence of any phospholipid.
Type:
Application
Filed:
June 30, 2004
Publication date:
October 25, 2007
Applicants:
THE BRIGHAM & WOMEN'S HOSPITAL, INC., U.S. DEPT. OF VETERANS AFFAIRS
Inventors:
Gary Gilbert, Jialan Shi, Christian Heegaard, Jan Rasmussen
Abstract: A synthetic tetrapeptide having an amino acide sequence, Glycine-Proline-Arginine-Proline (GPRP) has pro-inflammatory effects on human fibroblastic cells, including synovial cells. An amide analog of GPRP is ineffective in inducing, or effective in causing a loss of, pro-inflammatory effects.