Abstract: An ultrasound information processing system comprises a plurality of ultrasound devices coupled to a high-speed serial ultrasound information bus, wherein each ultrasound device comprises a program for communicating with other ultrasound devices according to an ultrasound information exchange protocol (UIEP). The UIEP is a lightweight, connection-oriented protocol adapted to efficiently transfer ultrasound information among different devices on the ultrasound information bus. Each ultrasound device comprises an application layer program for performing an ultrasound function, as well as a lower protocol layer program for receiving and sending data across the ultrasound information bus according to a high-speed serial bus standard that provides both isochronous and asynchronous data delivery.

Abstract: An adjunctive ultrasound mammography system and associated methods are described in which an ultrasound image being displayed near an x-ray mammogram image may be superimposed thereon or thereunder by a user for facilitating rapid comprehension of breast structures and detection of abnormalities therein. In one preferred embodiment, the x-ray mammogram image corresponds to a standard x-ray mammogram view, and the ultrasound image is a thick-slice image representing a thick-slice or slab-like portion of the breast volume substantially parallel to that standard x-ray mammogram view. In another preferred embodiment, the user is permitted to manually manipulate the registration of the ultrasound image with the x-ray mammogram image. It has been found that the manual registration process, which involves manual vernier adjustments responsive to perceived registration differences, can rapidly increase the radiologist's perception of the breast structures being displayed by both component images.

Abstract: An ultrasound information processing system is disclosed in which ultrasound image data is packetized into ultrasound information packets and routed to one or more of a plurality of processors for performing image processing operations on the ultrasound image data, the ultrasound information packets being routed according to entries in a host-programmable routing table. A common distribution bus is coupled between packetizing circuitry and dedicated input buffers corresponding to each processor for distributing the ultrasound information packets, and a common output bus to is used to transfer processed image data from the processors to an output device. The disclosed ultrasound information processing system architecture allows for a high throughput rate for accommodating real-time image processing operations, while also allowing for ready programmability and upgradability.

Abstract: An instrument guide is described for mounting an invasive instrument such as a biopsy needle to an imaging probe, controlling its position, monitoring its position, and/or predictively displaying its position on a user display of the medical imaging system. A plurality of substantially rigid segments are hingeably connected to the probe, to an instrument handle, and to each other such that movement of the biopsy needle is restricted to within the imaged plane. However, substantial freedom of movement within the imaged plane is provided such that the instrument may be inserted into the patient over a wide range of angles. In one preferred embodiment, angle detectors are provided at each segment intersection and measurements provided for computing and displaying the instrument position and orientation on the user display. The instrument guide/position monitor is preferably made with low-cost components such that it is disposable after a single use.

Abstract: A method, system, and computer program product for providing textual ultrasound probe position information corresponding to an ultrasound image of a target is described. Based on a user's graphical manipulations of a probe icon relative to a breast icon, a text sequence corresponding to the user's estimate of the position of an ultrasound probe is automatically generated. User error and fatigue are reduced because manual keying of the probe position text sequence is no longer required, and the resulting outputs are standardized in format and therefore more amenable to archiving and electronic analysis. In one preferred embodiment, the user is permitted to select a snapping mode of operation in which the probe icon is snapped to align with a major direction of a preselected coordinate system, further enhancing ease-of-use and reducing user fatigue.

Abstract: An adjunctive ultrasound mammography system and associated methods are described comprising an adjunctive ultrasound display configured for quick, intuitive, interactive viewing of data derived from volumetric ultrasound scans, the data being displayed near a conventional x-ray mammogram display. Preferred embodiments for navigating among a thick-slice image array, a selected enlarged thick-slice image, and planar ultrasound views are described, including a preferred embodiment in which the planar ultrasound views are updated in real time as a cursor is moved across an active thick-slice image. In one preferred embodiment the thick-slice images are inverted prior to display, with non-breast areas of the image preferably segmented out and reset to dark. The inverted thick-slice images are of more familiar significance to radiologists having years of expertise in analyzing conventional x-ray mammograms.

Abstract: An architecture and protocol are provided for allowing flexible, low cost, and upgradable ultrasound information processing systems. Ultrasound information processing functions are performed by a plurality of ultrasound modules coupled to a high-speed, multiple-drop serial ultrasound information bus. The ultrasound information bus is used for packetized data transfer among the ultrasound modules in accordance with an ultrasound information exchange protocol. Additional or upgraded ultrasound modules are designed to connect to the ultrasound information bus and to communicate using the ultrasound information exchange protocol. Thus, according to a preferred embodiment, as improvements in hardware technology or software algorithms are made, additional or upgraded ultrasound modules are simply “plugged in” to the ultrasound information bus, hereby reducing costs and increasing system versatility and upgradability.

Abstract: An extended view ultrasound imaging system in which a position sensor is used to detect the location and orientation of a ultrasound transducer for each scan frame as the ultrasound transducer is swept across the surface of a target. The contents of the successive scan frames, together with their location and orientation information, are processed to generate an extended view ultrasound image of the target region. An output array representing the extended view image is first initialized, and then successively updated as each scan frame is received. In a preferred embodiment, an alpha-blending algorithm is used to combine the information in the current scan frame with previous output array values to generate the current output array values.

Abstract: A method, system, computer program product, and user interface for real-time ultrasonic visualization enhancement of a biopsy needle are disclosed in which a wide range of needle positions with respect to the ultrasound probe axis and with respect to the imaged plane are accommodated. Ordinary frames are compounded with special purpose frames, the special purpose frames having transmit and receive parameters adapted to highlight reception of echoes from the biopsy needle. Preferably, an elevation beam width associated with the special purpose ultrasound frames is wider than an elevation beam width associated with the ordinary ultrasound frames. Preferably, the beams of the special purpose ultrasound frames are steered such that they are incident upon the biopsy needle at an increased angle as compared to the angle of incidence for ordinary ultrasound frames.

Abstract: An ultrasound system that generates compound images from component frames having decorrelated speckle patterns. Successive sets of distinct, speckle-affecting parameters are used to generate successive component frames for compounding, and are selected such that the successive component frames have decorrelated speckle patterns. The speckle-affecting parameters that are changed from frame to frame may be selected from a wide variety of parameters, including transmit beamformer parameters, receive beamformer parameters, and demodulator parameters. According to a preferred embodiment, the successive sets of speckle-affecting parameters differ from each other by at least two speckle-affecting parameters.

Abstract: An ultrasound imaging system capable of generating a flow image from B-mode echo frames. For each location in a target region, phase information is derived from the B-mode echo frames, and frame-to-frame changes in the phase information are processed to detect the presence of fluid flow at that location. A demodulator receives the B-mode echo frames and demodulates them into baseband signal components from which the phase information is derived. Preferably, the demodulator is highly accurate and robust, such that frame-to-frame changes in the phase information are reliably measured. From the reliably measured phase information, a phase shift metric is then computed and thresholded by a user-adjustable threshold value. Flow is present if the phase shift metric is greater than the threshold value and is absent otherwise.

Abstract: An adjunctive ultrasound mammography system and associated methods are described, comprising a scanning apparatus for facilitating standardized, repeatable breast ultrasound scans, and further comprising an adjunctive ultrasound display apparatus configured for fast, intuitive viewing of adjunctive ultrasound data concurrently with x-ray mammogram information. In one preferred embodiment, thick-slice ultrasound images are displayed near an x-ray mammogram such that a screening radiologist can quickly view the thick-slice images for assistance in interpreting the x-ray mammogram. Methods for concurrently acquiring and displaying vibrational resonance image (VDI) data are described. Computer-aided diagnosis (CAD) algorithms that incorporate acoustically-based feature vectors are described, the feature vectors including lateral shadow metrics, vertical shadow metrics, posterior enhancement metrics, and VDI-based metrics.

Abstract: A method, system, computer program product, and user interface for real-time ultrasonic visualization enhancement of a biopsy needle are disclosed in which a wide range of needle positions with respect to the ultrasound probe axis and with respect to the imaged plane are accommodated. Ordinary frames are compounded with special purpose frames, the special purpose frames having transmit and receive parameters adapted to highlight reception of echoes from the biopsy needle. Preferably, an elevation beam width associated with the special purpose ultrasound frames is wider than an elevation beam width associated with the ordinary ultrasound frames. Preferably, the beams of the special purpose ultrasound frames are steered such that they are incident upon the biopsy needle at an increased angle as compared to the angle of incidence for ordinary ultrasound frames.

Abstract: For use in medical procedures such as ultrasound-assisted biopsies in which an invasive medical instrument such as a biopsy needle is guided by a medical imaging system such as an ultrasound system, an instrument guide is described for mounting the instrument to an imaging probe, controlling its position, monitoring its position, and/or predictively displaying its position on a user display of the medical imaging system. A plurality of substantially rigid segments are hingeably connected to the probe, to an instrument handle, and to each other such that movement of the biopsy needle is restricted to within the imaged plane. However, substantial freedom of movement within the imaged plane is provided such that the instrument may be inserted into the patient over a wide range of angles. In one preferred embodiment, angle detectors are provided at each segment intersection and provided to the medical imaging system for computing and displaying the position and orientation of the instrument on the user display.

Abstract: A demodulator for use in an ultrasound information processing system is described, where in a preferred embodiment the demodulator uses a half-band filter to perform mirror-cancellation during the demodulation process. The demodulator comprises a mirror canceling quadrature mixer that mixes the input signal with quarter-sampling-frequency sinusoids and then low-pass-filters the mixed signals with half-band filters having a cutoff frequency of one-fourth the sampling frequency. In an ultrasound demodulator in accordance with a preferred embodiment, a significantly sharper mirror cancellation on the wideband input signal is achieved. Additionally, the number and complexity of mirror canceling filter operations significantly reduced, allowing for easier hardware implementation using less expensive, off-the-shelf components. Furthermore, simplified hardware for digitally providing harmonic imaging applications is achieved.