Abstract: The invention relates to derivatives of recombinant proteins, comprising homo-multimers of genetically fused recombinant biologically active protein monomer units, connected via selected peptide linker moiety; and the method of preparation thereof. Derivative of recombinant protein is preferably dimer of human granulocyte colony-stimulating factor, characterised by increased circulation time in vivo.
Type:
Grant
Filed:
August 9, 2011
Date of Patent:
January 26, 2016
Assignee:
UAB Profarma
Inventors:
Edita Mistiniene, Jonas Henrikas Pesliakas, Milda Pleckaityte, Gintautas Zvirblis