Patents Assigned to UAB Research Foundation
  • METHOD AND SYSTEM FOR EVALUATING BLOOD VESSEL
    Publication number: 20180125376
    Abstract: A method and system for evaluating physiological properties of a segment of blood vessel is provided. The method includes: acquiring a first measurement and a second measurement respectively at the first point and the second point; obtaining a transfer function configured to produce an output given an input, using the first measurement and the second measurement as the input and the output respectively; and determining the physiological properties of the section of the blood vessel based on the transfer function. The transfer function can be a velocity transfer function based on the blood velocity waveforms, or can be a pressure transfer function based on the blood pressure waveforms. The method and system can be used to non-invasively diagnose PH, COPD, and PA impedance in a pulmonary artery, and to detect a stenosis in a coronary artery.
    Type: Application
    Filed: November 10, 2017
    Publication date: May 10, 2018
    Applicants: Auburn University, The UAB Research Foundation
    Inventors: Thomas S. DENNEY, JR., Himanshu GUPTA, Ankur GUPTA
  • Systems and methods for encouraging hand washing compliance
    Patent number: 9940819
    Abstract: In some embodiments, a hand washing compliance system includes a primary soap dispenser adapted to be located near an entrance to a room, the primary soap dispenser comprising a motion sensor configured to detect passage of an individual through the room entrance, a soap dispensation sensor configured to detect dispensation of soap from the primary soap dispenser, and a communication device configured to enable communication with other soap dispensers, and a secondary soap dispenser adapted to be located inside of the room, the secondary soap dispenser comprising a soap dispensation sensor configured to detect dispensation of soap from the secondary soap dispenser, a communication device configured to enable communication with other soap dispensers, and a warning indicator configured to generate an alert that encourages individuals entering the room to wash their hands.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: April 10, 2018
    Assignee: THE UAB RESEARCH FOUNDATION
    Inventor: William Ferniany
  • Mid-IR microchip laser: ZnS:Cr2+ laser with saturable absorber material
    Patent number: 9887510
    Abstract: A method of fabrication of laser gain material and utilization of such media includes the steps of introducing a transitional metal, preferably Cr2+ thin film of controllable thickness on the ZnS crystal facets after crystal growth by means of pulse laser deposition or plasma sputtering, thermal annealing of the crystals for effective thermal diffusion of the dopant into the crystal volume with a temperature and exposition time providing the highest concentration of the dopant in the volume without degrading laser performance due to scattering and concentration quenching, and formation of a microchip laser either by means of direct deposition of mirrors on flat and parallel polished facets of a thin Cr:ZnS wafer or by relying on the internal reflectance of such facets.
    Type: Grant
    Filed: July 1, 2014
    Date of Patent: February 6, 2018
    Assignee: The UAB Research Foundation
    Inventors: Sergey B. Mirov, Vladimir V. Fedorov
  • Mitochondrially-targeted electrophilic compounds and methods of use for the treatment of cancer
    Patent number: 9872868
    Abstract: The present invention provides methods, compounds, compositions and kits including mitochondrially-targeted electrophilic (MTE) compounds that are useful for treating cancer.
    Type: Grant
    Filed: August 15, 2014
    Date of Patent: January 23, 2018
    Assignee: UAB Research Foundation
    Inventors: Aimee Morrison, Sadanandan Velu
  • Nitrated lipids and methods of making and using thereof
    Patent number: 9867795
    Abstract: Described herein are nitrated lipids and methods of making and using the nitrated lipids.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: January 16, 2018
    Assignees: The UAB Research Foundation, The State of Oregon Acting by and through the State Board of Higher Education on Behalf of the University of Oregon, University College Cardiff Consultants Limited, Morehouse School of Medicine, Inc.
    Inventors: Bruce A. Freeman, Francisco Schopfer, Valerie O'Donnell, Paul Baker, Yuqing E. Chen, Bruce Branchaud
  • Self-restoring crash cushions
    Patent number: 9856616
    Abstract: A self-restoring crash cushion including multiple diaphragms spaced along a length direction of the cushion, an elongated track adapted to be anchored to the ground that extends along the length direction under the cushion, the diaphragms being mounted to the track in a manner in which they can slide along the track when impacted by a moving vehicle or when the cushion is being restored, and means for dissipating energy of the moving vehicle.
    Type: Grant
    Filed: March 7, 2015
    Date of Patent: January 2, 2018
    Assignee: The UAB Research Foundation
    Inventors: Dean Sicking, David Littlefield, Kenneth Walls, Seth Cohen, Kevin Schrum
  • Mosaic clade M human immunodeficiency virus type 1 (HIV-1) gag immunogens
    Patent number: 9844590
    Abstract: The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: December 19, 2017
    Assignees: Duke University, Los Alamos National Security, LLC, Beth Israel Deconess Medical Center, The UAB Research Foundation
    Inventors: Bette T. Korber, William Fischer, Norman Letvin, Hua-Xin Liao, Barton F. Haynes, Beatrice H. Hahn
  • Human Immunodeficiency Virus type 1 group M consensus and mosaic envelope glycoproteins
    Patent number: 9821053
    Abstract: The disclosure relates to nucleic acids mosaic clade M HIV-1 Env polypeptides and to compositions and vectors comprising same. The nucleic acids are suitable for use in inducing an immune response to HIV-1 in a human.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: November 21, 2017
    Assignees: Duke University, Los Alamos National Security, LLC, The UAB Research Foundation, Beth Israel Deaconess Medical Center
    Inventors: Bette T. Korber, William Fischer, Hua-Xin Liao, Barton F. Haynes, Norman Letvin, Beatrice H. Hahn
  • Hinged microfracture awls
    Patent number: 9808264
    Abstract: In one embodiment, a hinged microfracture awl includes a handle, and a shaft that extends through and from the handle, the shaft being pivotally mounted to the handle with a hinge, wherein a distal end of the shaft includes a sharp tip adapted to pierce bone and a proximal end of the shaft includes an impact head adapted to be struck by a striking tool.
    Type: Grant
    Filed: May 21, 2015
    Date of Patent: November 7, 2017
    Assignees: THE UAB RESEARCH FOUNDATION, SOUTHERN RESEARCH INSTITUTE
    Inventors: Reed Estes, Patrick Schexnailder, Robert Hergenrother
  • Materials and methods for treating diseases caused by genetic disorders using aminoglycosides and derivatives thereof which exhibit low nephrotoxicity
    Patent number: 9775854
    Abstract: Various aspects related to the preparation of congeners of the aminoglycosides gentamicin such as the congener C2 and using this compound or derivatives thereof and pharmaceutically active salts to treat diseases that involve genetic mutations which introduce a missense or premature stop codon into a gene. Still other aspects include treating human or animal patients with the gentamicin congener C2 and derivatives and pharmaceutical salt thereof to overcome, or to at least mitigate, the symptoms of disease and disorders such as some forms of Becker's or Duchenne muscular dystrophy, Hurler's Syndrome and Cystic Fibrosis that have as their etiology the presence of a premature stop codon in a gene whose proper expression is necessary for good health.
    Type: Grant
    Filed: January 5, 2015
    Date of Patent: October 3, 2017
    Assignees: Indiana University Research and Technology Corporation, UAB Research Foundation
    Inventors: Bruce A. Molitoris, David M. Bedwell, Ruben M. Sandoval
  • Pneumococcal serotypes
    Patent number: 9778266
    Abstract: Disclosed is a new and emerging serotype of Streptococcus pneumoniae designated serotype 6C, and assays and monoclonal antibodies useful in identifying same. Also disclosed is a novel pneumococcal polysaccharide with the repeating unit {2) glucose 1 (1?3) glucose 2 (1?3) rhamnose (1?3) ribitol (5?phosphate}. This new serotype may be included in pneumococcal vaccines.
    Type: Grant
    Filed: May 9, 2013
    Date of Patent: October 3, 2017
    Assignees: The UAB Research Foundation, Fundacao Oswaldo Cruz, Instituto Adolfo Lutz
    Inventors: Moon H. Nahm, Jisheng Lin, Angela P. Brandao, Maria Cristina Brandileone
  • Biodegradable photocatalytic nanocomposite microsponges of polyactic acid
    Patent number: 9764316
    Abstract: Despite significant progress in the synthesis of nanocomposite materials, integration of several components with various functions remains a big challenge, which significantly limits control over nanocomposite properties. The disclosure provides a multifunctional micro particle based on incorporation of titania nanoparticles combined into a porous polylactic acid (PLA) matrix. PLA is used as a biodegradable and biocompatible polymer and titania nanoparticles represent photocatalytically active nanofillers capable of degradation of organic compounds under solar irradiation. Titania nanoparticles are integrated with PLA by using ‘mixed’ and ‘in situ grown’ approaches. The hybrid systems effectively absorbed and degraded organic impurities from water. The sorption capacity, dye degradability, and PLA disintegration were controlled by varying the concentration of incorporated titania.
    Type: Grant
    Filed: June 18, 2012
    Date of Patent: September 19, 2017
    Assignee: The UAB Research Foundation
    Inventors: Eugenia P. Kharlampieva, Benjamin Yancey
  • System and method for image registration of multiple video streams
    Patent number: 9760687
    Abstract: Provided herein are methods and systems for image registration from multiple sources. A method for image registration includes rendering a common field of interest that reflects a presence of a plurality of elements, wherein at least one of the elements is a remote element located remotely from another of the elements and updating the common field of interest such that the presence of the at least one of the elements is registered relative to another of the elements.
    Type: Grant
    Filed: August 12, 2011
    Date of Patent: September 12, 2017
    Assignees: UAB RESEARCH FOUNDATION, HELP LIGHTNING, INC.
    Inventors: Marcus W. Dillavou, Phillip Corey Shum, Baron L. Guthrie, Mahesh B. Shenai, Drew Steven Deaton, Matthew Benton May
  • AMYOTROPHIC LATERAL SCLEROSIS (ALS) BIOMARKERS AND USES THEREOF
    Publication number: 20170248579
    Abstract: Provided herein are Amyotrophic lateral sclerosis (ALS) biomarkers and methods of using these ALS biomarkers to diagnose and treat ALS.
    Type: Application
    Filed: September 10, 2015
    Publication date: August 31, 2017
    Applicant: The UAB Research Foundation
    Inventor: Peter H. King
  • Method and apparatus for the detection of impaired dark adaptation
    Patent number: 9730579
    Abstract: The present method describes a new method for the measurement of dark adaptation. The dark adaptation status of subjects may then be used to identify those subjects who are at risk of developing and/or who are currently suffering from a variety of disease states having their clinical manifestations in impaired dark adaptation. The disease states include, but are not limited to, age related macular degeneration, vitamin A deficiency, Sorsby's Fundus Dystrophy, late autosomal dominant retinal degeneration, retinal impairment related to diabetes and diabetic retinopathy. An apparatus for administering the test method described is also provided.
    Type: Grant
    Filed: May 7, 2015
    Date of Patent: August 15, 2017
    Assignee: The UAB Research Foundation
    Inventors: Gregory R Jackson, Cynthia Owsley
  • MSP NANOPORES AND RELATED METHODS
    Publication number: 20170218443
    Abstract: Provided herein are Mycobacterium smegmatis porin nanopores, systems that comprise these nanopores, and methods of using and making these nanopores. Such nanopores may be wild-type MspA porins, mutant MspA porins, wild-type MspA paralog porins, wild-type MspA homolog porins, mutant MspA paralog porins, mutant MspA homolog porins, or single-chain Msp porins. Also provided are bacterial strains capable of inducible Msp porin expression.
    Type: Application
    Filed: April 14, 2017
    Publication date: August 3, 2017
    Applicants: University of Washington, The UAB Research Foundation
    Inventors: Jens H. Gundlach, Michael Niederweis, Thomas Z. Butler, Mikhail Pavlenok, Mark A. Troll, Suja Sukumaran
  • Antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof
    Patent number: 9700618
    Abstract: An antibody of the invention interacts with human DR5 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Nucleic acid sequences and amino acid sequences of anti-DR5 antibodies have been elucidated and vectors and cells containing and expressing these sequences have been generated. Methods and uses for the antibodies are detailed including treatment of apoptosis-related disease and treatment of dysregulated cell growth.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: July 11, 2017
    Assignee: The UAB Research Foundation
    Inventors: Tong Zhou, Kimihisa Ichikawa, Robert P. Kimberly, William J. Koopman
  • Use of nitrite salts for the treatment of cardiovascular conditions
    Patent number: 9700578
    Abstract: It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.
    Type: Grant
    Filed: January 5, 2015
    Date of Patent: July 11, 2017
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, Acting through the Louisiana State University Health Sciences Center, The UAB Research Foundation, Loma Linda University, Wake Forest University
    Inventors: Mark T. Gladwin, Alan N. Schechter, David J. Lefer, Rakesh P. Patel, Christian J. Hunter, Gordon G. Power, Daniel B. Kim-Shapiro, Ryszard Marek Pluta, Edward H. Oldfield, Richard O. Cannon, III
  • RECLINING TRANSPORT CHAIRS
    Publication number: 20170172825
    Abstract: A transport chair is provided that includes a base frame, a seat assembly pivotally mounted to the base, and a footrest assembly pivotally mounted to the base frame, the footrest assembly being associated with the seat assembly so as to pivot in unison with the seat assembly until the seat assembly is pivoted forward to an extent at which the footrest assembly contacts the floor or ground, at which point the footrest assembly does not pivot further upon further forward pivoting of the seat assembly. Further embodiments of the transport chair allow the seat assembly to recline, alone or in unison with a leg rest assembly, while the footrest remains in position.
    Type: Application
    Filed: March 7, 2017
    Publication date: June 22, 2017
    Applicant: THE UAB RESEARCH FOUNDATION
    Inventors: William FERNIANY, Lloyd Cooper
  • Protective helmet shell
    Patent number: D805255
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: December 12, 2017
    Assignee: The UAB Research Foundation
    Inventors: Brandon Hefer, Aaron Brookhart, Jordan Westerberg