Abstract: The present invention provides anti-TNF? antibodies which selectively inhibit TNF? signalling through the p55R. In particular the present invention provides anti-TNF? antibodies which selectively inhibit TNF? signalling through the p55R relative to the p75R.

Abstract: A series of substituted 4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

Abstract: Provided is a cassette unit suitable for use with an auto-injector having a drive unit. The cassette unit comprises a cassette unit housing defining a cassette unit housing cavity arranged for receipt of a syringe; a needle projection aperture; a needle cover defining a needle sheath for sheathing of a needle tip of the syringe; a removable cap that in a capping position fits over and thereby, acts such as to close off, the needle projection aperture, the removable cap defining a cap interior; provided to the removable cap, a cap insert; and provided to the cap insert, a connector defining one or more needle cover gripping elements for gripping the needle cover and the connector defines a central hub and the one or more needle gripper elements attach to the central hub and in spaced arrangement relative to each other.

Abstract: A series of substituted heteroaromatic compounds containing two fused six-membered rings, tivity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

Abstract: There is provided a cassette unit that is suitable for use with an auto-injector having an electrically powered drive unit. The cassette unit has a housing defining a cassette unit housing cavity and a needle projection aperture. The cassette unit housing cavity is arranged for receipt of a syringe that is suitable for use in the injected delivery of drug to a patient. The cassette unit includes a removable cap that fits over and thereby, acts such as to close off, the needle projection aperture; and connecting to the removable cap, a needle cover defining a needle sheath for sheathing of the needle tip of the syringe. The removable cap is provided with a finger-grip feature that is sized and shaped for gripping by the finger of a user to allow for removal of the removable cap and needle cover from the cassette unit housing.

Abstract: A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in SEQ ID NO: 1 or SEQ ID NO:2 and/or comprising a light chain variable domain having the sequence given in SEQ ID NO:3 or SEQ ID NO:4, in particular comprising a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 1 and SEQ ID NO:3 or a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 2 and SEQ ID NO:4. The disclosure also extends to polynucleotides encoding the antibodies or fragments, vectors comprising same and host cells capable of expressing the polynucleotides. The disclosure further includes pharmaceutical compositions comprising the antibodies or fragments and therapeutic used of any one of the same.

Abstract: Provided is a cassette unit suitable for use with an auto-injector having an electrically powered drive unit. The cassette unit has a housing defining a cassette unit housing cavity and a needle projection aperture. The housing cavity is arranged for receipt of a syringe suitable for use in the injected delivery of drug to a patient. The syringe has a barrel for containing a volume of a liquid drug formulation, the barrel defining an end flange at the rear end thereof and a forward shoulder at the forward end thereof. The cassette unit includes a sleeve form adapter arranged for receipt by the syringe barrel and to fit at least partly over the end flange of the syringe barrel. Accommodation of different syringe sizes within the same cassette unit geometry is achievable by selecting a sleeve form adapter tailored to the particular sizing of the barrel of each different syringe.

Abstract: Provided is a cassette unit suitable for use with an auto-injector having a drive unit. The cassette unit comprises a cassette unit housing defining a cassette unit housing cavity, which is in receipt of a syringe, a rearward entrance to said cavity and a forward needle projection aperture. The cassette unit also comprises in capping relationship with the rearward entrance of the cassette unit housing, a cassette unit end-cap, said cassette unit end-cap defining a drive rod-receiving opening for receipt of a drive rod for providing forward axial drive to said plunger; a biasing element defining a biasing relationship between the cassette unit end-cap and an end flange of the syringe barrel, thereby urging the syringe forwards in relation to the cassette unit end-cap; and a damping element defining a damping relationship between the cassette unit end-cap and the flange of the syringe, thereby acting to damp rearward movement of the syringe relative to the cassette unit end-cap.

Abstract: The present invention relates neutralizing epitopes of IL-17A and IL-17F and antibodies which bind those epitopes. The present invention also relates to the therapeutic uses of the antibody molecules and methods for producing them.

Abstract: There is provided an auto-injector for a syringe that is suitable for use in the injected delivery of drug to a patient. The auto-injector comprises a cassette unit arranged for receipt of a syringe provided with a needle cover and removable cap. The auto-injector also comprises a drive unit arranged for docking receipt of the cassette unit at a docking position and a drive arrangement. The drive unit is provided with a timer that starts a time count on removal of the removable cap and needle cover from the cassette unit.

Abstract: There is provided a cassette unit suitable for use with an auto-injector. The cassette unit comprises a cassette unit housing and a removable cap that in a capping position fits over and thereby, acts to close off, a needle projection aperture of the housing. The cassette unit housing has one or more first engagement features arranged for reversibly engaging one or more second engagement features of the removable cap for reversible lock engagement of the removable cap to the housing; and a shuttle lock control defining one or more blocking elements for selectively blocking movement of said first engagement features relative to said second engagement features. The shuttle lock control is axially movable relative to the cassette unit housing between a first ‘cassette unused’ position; a second ‘cassette unlocked’ position; and after replacement of the removable cap, a third ‘cassette used’ position, locating intermediate the first and second positions.

Abstract: Provided is a cassette unit suitable for use with an auto-injector having an electrically powered drive unit. The cassette unit comprises a cassette unit housing defining a cassette unit housing cavity and a needle projection aperture. The housing cavity may receive a syringe. Axially movable within the barrel of the syringe for forward movement into contact with the syringe plunger, there is a plunger slaving part defining a circumferential wall arranged for frictional sliding relationship with the inner wall of the barrel, a rear drive-receiving face and a front plunger-contacting face. The plunger slaving part is arranged such that when a drive load is applied to its rear drive-receiving face to bring the front plunger-contacting face into contact with the plunger the drive load is evenly transmitted. The circumferential wall is provided with slide restrictors that restrict frictional sliding movement thereof in relation to the inner wall of the barrel.

Abstract: Provided is a cassette unit suitable for use with an auto-injector having an electrically powered drive unit. The cassette unit comprises a cassette unit housing defining a housing cavity, a rearward entrance to the cavity and a forward needle projection aperture. The housing cavity may receive a syringe. Axially movable within the barrel of the syringe for forward movement into contact with the syringe plunger, there is a plunger slaving part defining a circumferential wall arranged for frictional sliding relationship with the inner wall of the barrel, a rear drive-receiving face and a front plunger-contacting face. In capping relationship with the rearward entrance of the cassette unit housing there is an end-cap defining a drive rod-receiving opening for receipt of a drive rod for providing forward axial drive to the plunger slaving part. In a pre-use configuration, the plunger slaving part is shaped for releasable engagement with the end-cap.

Abstract: Provided is a cassette unit suitable for use with an auto-injector having an electrically powered drive unit. The cassette unit comprises a cassette unit housing defining a cassette unit housing cavity, a rearward entrance to said cavity and a forward needle projection aperture. The housing cavity may receive a syringe comprising a barrel; a needle at a front end of the barrel; and a plunger that is axially movable within the barrel. The cassette unit also comprises in capping relationship with the rearward entrance of the cassette unit housing, a cassette unit end-cap, said cassette unit end-cap defining a drive rod-receiving opening for receipt of a drive rod for providing forward axial drive to said plunger; and a biasing element defining a biasing relationship between the cassette unit end-cap and an end flange of the syringe barrel, thereby urging the syringe forwards in relation to the cassette unit end cap.

Abstract: An anti-E1 ion channel antibody or binding fragment thereof, pharmaceutical compositions comprising said antibodies, use of the antibodies and compositions comprising the same, in treatment, for example in the treatment/modulation of pain and processes for generating and preparing said antibodies.

Abstract: A series of substituted imidazo[1,2-b][1,2,4]triazine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

Abstract: The present disclosure relates to multispecific molecule comprising a binding domain specific to the antigen CD22 and a binding domain specific to the antigen CD79a and/or CD79b, compositions comprising the same and use of both in treatment, for example the treatment of autoimmune disease.

Abstract: Provided is an auto-injector for a syringe suitable for the injected delivery of drug to a patient. The auto-injector comprises a cassette unit arranged for receipt of a syringe. The cassette unit and/or syringe is movable from a rest position, in which the syringe needle tip is within the drive unit housing to a use position, in which the needle tip protrudes from a needle delivery aperture thereof. The auto-injector comprises a drive unit arranged for docking receipt of the cassette unit at a docking position and a drive arrangement. The drive unit is arranged for initial receipt of the cassette unit at an intermediate pre-docking position and for subsequent transport of the cassette unit to the docking position. In embodiments, the drive unit is arranged such that transport of the cassette unit to the docking position is permitted only following verification of an identifier at the intermediate pre-docking position.