Patents Assigned to UCB Pharma S.A.
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Patent number: 11339214Abstract: The present invention relates to a process for the purification of an antibody fragment from a periplasmic cell extract comprising a first cation exchange chromatography step and a second anion exchange chromatography step.Type: GrantFiled: January 16, 2019Date of Patent: May 24, 2022Assignee: UCB PHARMA, S.A.Inventors: Mariangela Spitali, Jonathan Symmons, Richard Whitcombe, Mark Robert Pearce-Higgins
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Publication number: 20210060160Abstract: The invention relates to the treatment of bone disorders. In particular, the invention is directed to the use of a dosing holiday to help overcome the resistance to anti-sclerostin antibodies which develops over time when a plurality of doses of antibody are given to a subject. By giving the subject to be treated such a dosing holiday, the subject may subsequently display an increased response to a subsequent dose of the anti-sclerostin antibody. The subject may be given multiple cycles of a batch of at least two doses of anti-sclerostin antibody and a dosing holiday. In some instances, the subject may be monitored to help determine when to give the dosing holiday. Further, the subject may be given a different treatment for the bone disorder during the dosing holiday from the anti-sclerostin antibody.Type: ApplicationFiled: September 14, 2020Publication date: March 4, 2021Applicant: UCB PHARMA, S.A.Inventor: Martyn K. Robinson
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Patent number: 10799583Abstract: The invention relates to the treatment of bone disorders. In particular, the invention is directed to the use of a dosing holiday to help overcome the resistance to anti-sclerostin antibodies which develops over time when a plurality of doses of antibody are given to a subject. By giving the subject to be treated such a dosing holiday, the subject may subsequently display an increased response to a subsequent dose of the anti-sclerostin antibody. The subject may be given multiple cycles of a batch of at least two doses of anti-sclerostin antibody and a dosing holiday. In some instances, the subject may be monitored to help determine when to give the dosing holiday. Further, the subject may be given a different treatment for the bone disorder during the dosing holiday from the anti-sclerostin antibody.Type: GrantFiled: February 2, 2018Date of Patent: October 13, 2020Assignee: UCB PHARMA, S.A.Inventor: Martyn K. Robinson
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Patent number: 10189897Abstract: The present invention relates to a process for the purification of an antibody fragment from a periplasmic cell extract comprising a first cation exchange chromatography step and a second anion exchange chromatography step.Type: GrantFiled: December 22, 2015Date of Patent: January 29, 2019Assignee: UCB PHARMA, S.A.Inventors: Mariangela Spitali, Jonathan Symmons, Richard Whitcombe, Mark Robert Pearce-Higgins
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Patent number: 10017575Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.Type: GrantFiled: August 19, 2016Date of Patent: July 10, 2018Assignee: UCB Pharma S.A.Inventors: Alastair David Griffiths Lawson, Andrew Malcolm Nesbitt, Andrew George Popplewell, Stevan Graham Shaw, Diana Shpektor, Yi Zhang
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Publication number: 20180169235Abstract: The invention relates to the treatment of bone disorders. In particular, the invention is directed to the use of a dosing holiday to help overcome the resistance to anti-sclerostin antibodies which develops over time when a plurality of doses of antibody are given to a subject. By giving the subject to be treated such a dosing holiday, the subject may subsequently display an increased response to a subsequent dose of the anti-sclerostin antibody. The subject may be given multiple cycles of a batch of at least two doses of anti-sclerostin antibody and a dosing holiday. In some instances, the subject may be monitored to help determine when to give the dosing holiday. Further, the subject may be given a different treatment for the bone disorder during the dosing holiday from the anti-sclerostin antibody.Type: ApplicationFiled: February 2, 2018Publication date: June 21, 2018Applicant: UCB PHARMA, S.A.Inventor: Martyn K. Robinson
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Patent number: 9957328Abstract: The present invention provides a recombinant gram-negative bacterial cell comprising an expression vector comprising a recombinant polynucleotide encoding DsbC and one or more polynucleotides encoding an antibody or an antigen-binding fragment thereof specifically binding to CD154.Type: GrantFiled: August 3, 2017Date of Patent: May 1, 2018Assignee: UCB PHARMA, S.A.Inventors: Mark Ellis, David Paul Humphreys
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Patent number: 9925260Abstract: The invention relates to the treatment of bone disorders. In particular, the invention is directed to the use of a dosing holiday to help overcome the resistance to anti-sclerostin antibodies which develops over time when a plurality of doses of antibody are given to a subject. By giving the subject to be treated such a dosing holiday, the subject may subsequently display an increased response to a subsequent dose of the anti-sclerostin antibody. The subject may be given multiple cycles of a batch of at least two doses of anti-sclerostin antibody and a dosing holiday. In some instances, the subject may be monitored to help determine when to give the dosing holiday. Further, the subject may be given a different treatment for the bone disorder during the dosing holiday from the anti-sclerostin antibody.Type: GrantFiled: July 3, 2013Date of Patent: March 27, 2018Assignee: UCB PHARMA S.A.Inventor: Martyn Kim Robinson
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Patent number: 9828438Abstract: The present invention provides dual specificity antibody fusion proteins comprising an antibody Fab or Fab? fragment with specificity for an antigen of interest, said fragment being fused to at least one single domain antibody which has specificity for a second antigen of interest.Type: GrantFiled: July 6, 2016Date of Patent: November 28, 2017Assignee: UCB Pharma S.A.Inventors: David Paul Humphreys, Emma Dave, Laura Griffin, Sam Philip Heywood
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Publication number: 20170306052Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.Type: ApplicationFiled: April 7, 2017Publication date: October 26, 2017Applicant: UCB PHARMA S.A.Inventors: Ralph Adams, Andrew George Popplewell, Stephen Edward Rapecki
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Patent number: 9791462Abstract: A novel class or family of TGF-? binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.Type: GrantFiled: February 19, 2015Date of Patent: October 17, 2017Assignee: UCB PHARMA, S.A.Inventors: Mary E. Brunkow, David J. Galas, Brian Kovacevich, John T. Mulligan, Bryan W. Paeper, Jeffrey Van Ness, David G. Winkler
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Patent number: 9751930Abstract: The present invention provides method for purifying a recombinant protein from a gram-negative bacterial host cell sample or extract thereof wherein said host cell expresses a recombinant protein and a recombinant disulphide isomerase DsbC; comprising: a. adjusting the pH of the host cell sample or extract thereof to a pH of 5 or less to precipitate the recombinant disulphide isomerase; and b. separating precipitated recombinant disulphide isomerase DsbC from the recombinant protein to produce a recombinant protein sample.Type: GrantFiled: July 27, 2011Date of Patent: September 5, 2017Assignee: UCB PHARMA, S.A.Inventor: Gavin Barry Wild
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Patent number: 9725516Abstract: The present invention provides a recombinant gram-negative bacterial cell comprising an expression vector comprising a recombinant polynucleotide encoding DsbC and one or more polynucleotides encoding an antibody or an antigen-binding fragment thereof specifically binding to CD154.Type: GrantFiled: July 13, 2012Date of Patent: August 8, 2017Assignee: UCB PHARMA, S.A.Inventors: Mark Ellis, David Paul Humphreys
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Publication number: 20170182159Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of IL-6, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.Type: ApplicationFiled: March 6, 2017Publication date: June 29, 2017Applicant: UCB Pharma S.A.Inventors: Richard Evan Gelinas, Mitra Choudhury Singhal, Yi Zhang, Andrew George Popplewell, Ralph Adams
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Patent number: 9657095Abstract: Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.Type: GrantFiled: March 19, 2015Date of Patent: May 23, 2017Assignee: UCB PHARMA S.A.Inventors: David G. Winkler, Jiye Shi, John Latham
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Patent number: 9631015Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of IL-6, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.Type: GrantFiled: July 9, 2015Date of Patent: April 25, 2017Assignee: UCB Pharma S.A.Inventors: Richard Evan Gelinas, Mitra Choudhury Singhal, Yi Zhang, Andrew George Popplewell, Ralph Adams
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Patent number: 9630948Abstract: The invention relates to 2-oxo-1-pyrrolidinyl triazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals for enhancing the cognitive function or to counteract cognitive decline.Type: GrantFiled: July 28, 2014Date of Patent: April 25, 2017Assignee: UCB Pharma, S.A.Inventors: Florian Montel, Eric Jnoff
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Patent number: 9587227Abstract: The present invention provides a recombinant gram-negative bacterial cell comprising a mutant spr gene encoding a spr protein having a mutation at one or more amino acids selected from D133, H145, H157, N31, R62, 170, Q73, C94, S95, V98, Q99, R100, L108, Y115, V135, L136, G140, R144 and G147 and wherein the cell has reduced Tsp protein activity compared to a wild-type cell.Type: GrantFiled: January 20, 2015Date of Patent: March 7, 2017Assignee: UCB PHARMA, S.A.Inventors: Mark Ellis, David Paul Humphreys
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Patent number: 9550973Abstract: A recombinant gram-negative bacterial cell comprising one or more of the following mutated protease genes: a) a mutated Tsp gene, wherein the mutated Tsp gene encodes a Tsp protein having reduced protease activity or is a knockout mutated Tsp gene; b) a mutated ptr gene, wherein the mutated ptr gene encodes a Protease III protein having reduced protease activity or is a knockout mutated ptr gene; and c) a mutated DegP gene encoding a DegP protein having chaperone activity and reduced protease activity; wherein the cell is isogenic to a wild-type bacterial cell except for the mutated Tsp gene and/or mutated ptr gene and/or mutated DegP gene and optionally a polynucleotide sequence encoding a protein of interest.Type: GrantFiled: March 29, 2016Date of Patent: January 24, 2017Assignee: UCB PHARMA, S.A.Inventors: Mark Ellis, David Paul Humphreys
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Patent number: 9493559Abstract: The present invention provides a recombinant gram-negative bacterial cell, characterized in that the cell comprises a recombinant polynucleotide encoding DsbC and has reduced Tsp protein activity compared to a wild-type cell.Type: GrantFiled: February 27, 2015Date of Patent: November 15, 2016Assignee: UCB PHARMA, S.A.Inventors: Mark Ellis, David Paul Humphreys