Patents Assigned to UCB, S.A.
  • Process for the preparation of 2-oxo-1-pyrrolidine derivatives
    Patent number: 8338621
    Abstract: The present invention relates to alternative processes for the preparation of 2-oxo-1-pyrrolidine derivatives of formula (I) Particularly, the present invention relates to alternative processes for the synthesis of levetiracetam, brivaracetam and seletracetam.
    Type: Grant
    Filed: December 19, 2006
    Date of Patent: December 25, 2012
    Assignee: UCB S.A.
    Inventors: John Surtees, Didier Bouvy, Antoine Thomas, Yves Combret, Michael Frank, Gunther Schmidt, Guy Duchene
  • Novel Pharmaceutical Compositions Comprising Levetiracetam
    Publication number: 20110027359
    Abstract: The present invention relates to a pharmaceutical composition comprising levetiracetam as active ingredient, the invention relates specifically to a prolonged release formulation.
    Type: Application
    Filed: March 10, 2010
    Publication date: February 3, 2011
    Applicant: UCB, S.A.
    Inventors: Caroline Goffin, Monique Berwaer, Michaël Boonen, Michel Deleers, Domenico Fanara
  • 2,6-quinolinyl derivatives, processes for preparing them and their uses
    Patent number: 7732614
    Abstract: The present invention concerns 2,6-quinolinyl derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
    Type: Grant
    Filed: June 9, 2006
    Date of Patent: June 8, 2010
    Assignee: UCB S.A.
    Inventor: Benjamin Perry
  • 2-OXO-1-PYRROLIDINE DERIVATIVES
    Publication number: 20090156607
    Abstract: The present invention concerns 2-oxo-1-pyrrolidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
    Type: Application
    Filed: May 31, 2006
    Publication date: June 18, 2009
    Applicant: UCB, S.A.
    Inventors: Benoit Kenda, Yannick Quesnel, Ali Ates, Philippe Michel, Laurent Turet, Joel Mercier
  • Chemical compounds with dual activity, processes for their preparation and pharmaceutical compositions
    Patent number: 7544675
    Abstract: The present invention concerns chemical compounds combining affinity and antagonism against the human m3 muscarinic receptor with activity as selective phosphodiesterase IV (PDE IV) inhibitors, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
    Type: Grant
    Filed: March 29, 2003
    Date of Patent: June 9, 2009
    Assignee: UCB, S.A.
    Inventors: Laurent Provins, Berend Jan Van Keulen, John Surtees, Patrice Talaga, Bernard Christophe
  • 2-Oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivatives for the treatment of epilepsy and other neurological disorders
    Patent number: 7473697
    Abstract: This invention relates to new 2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivatives of formula (1) having anticonvulsant activity which are useful as therapeutic agents for the treatment or prevention of epilepsy and other neurological disorders. The invention also concerns processes for preparing these derivatives and novel intermediates used in the preparation of these derivatives.
    Type: Grant
    Filed: June 15, 2006
    Date of Patent: January 6, 2009
    Assignee: UCB S.A.
    Inventors: Philippe Michel, Benoît Kenda
  • Methods for identifying agents that bind a levetiracetam binding site (LBS) or compete with LEV binding to a LBS of a synaptic vesicle protein 2 (SV2)
    Patent number: 7465549
    Abstract: The present invention is drawn to methods of characterization of the properties and functions of SV2 proteins. The invention further includes methods of identifying compounds or agents which modulate the activity of SV2 proteins. Included in these methods is the identification of compounds or agents which modulate the binding of levetiracetam to SV2 proteins, including SV2A. Additionally, the present invention provides biotinylated ligands as a tool to screen chemical libraries and characterize the SV2 proteins. Further, the present invention provides a method of solubilizing and purifying functionally active membrane associated proteins, such as SV2.
    Type: Grant
    Filed: December 2, 2003
    Date of Patent: December 16, 2008
    Assignee: UCB, S.A.
    Inventors: Berkley Lynch, Karl Nocka, Bruno Fuks
  • TABLET COMPRISING EFLETIRIZINE AND PSEUDOEPHEDRINE
    Publication number: 20080206331
    Abstract: The present invention concerns a tablet comprising two distinct segments. More particularly the invention relates to combinations of two pharmaceutical substances and methods of treatment of allergic disorders.
    Type: Application
    Filed: June 14, 2007
    Publication date: August 28, 2008
    Applicant: UCB, S.A.
    Inventors: Monique Berwaer, Anthony Guichaux, Serge Cuypers, Michel Deleers, Domenico Fanara
  • Piperazine derivatives and their use as synthesis intermediates
    Patent number: 7381821
    Abstract: The present invention relates to new enantiomerically pure piperazine derivatives of formula (I) wherein Y represents hydroxy or a leaving group and n is 1, 2, 3, 4 or 5, and to their use as synthesis intermediates, especially for the preparation of pharmaceutically active compounds
    Type: Grant
    Filed: January 20, 2004
    Date of Patent: June 3, 2008
    Assignee: UCB, S.A.
    Inventors: Célal Ates, Emile Cavoy, Didier Bouvy
  • Process for Preparing 2-Oxo-1-Pyrrolidine Derivatives by Intramolecular Allylation
    Publication number: 20080125598
    Abstract: The present invention relates to a new process for preparing 2-oxo-1-pynolidine derivatives of general formula (I), comprising the cyclisation of an intermediate of general formula (II) wherein the substituents are as defined in the specification.
    Type: Application
    Filed: May 26, 2005
    Publication date: May 29, 2008
    Applicant: UCB, S.A.
    Inventors: Francoise Lurquin, Frank Driessens, Michel Callaert
  • Quinuclidine derivatives processes for preparing them and their uses as m2 and/or m3 muscarinic receptor inhibitors
    Patent number: 7361668
    Abstract: The invention concerns quinuclidine derivatives of formula I or II wherein the substituents are as defined in the specification, as well as their use as pharmaceuticals. The compounds of the invention show high affinities for m3 and/or m2 muscarinic receptors and are particularly suited for treating urinary incontinence.
    Type: Grant
    Filed: September 23, 2002
    Date of Patent: April 22, 2008
    Assignee: UCB, S.A.
    Inventors: Michel Guyaux, Chimmanamada U. Dinesh, Charles Mioskowski, Luc Quere, Jean-Philippe Starck, Patrice Talaga, Alain Wagner, Matteo Zanda
  • 2-Oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
    Patent number: 7358276
    Abstract: The invention concerns 2-oxo-1-pyrrolidine derivatives of formula I, wherein the substituents are as defined in the specification, as well as their use as pharmaceuticals. The compounds of the invention are particularly suited for treating neurological disorders such as epilepsy.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: April 15, 2008
    Assignee: UCB, S.A.
    Inventors: Edmond Differding, Benoît Kenda, Bénédicte Lallemand, Alain Matagne, Philippe Michel, Patrick Pasau, Patrice Talaga
  • Acetonitrile Recycling Process
    Publication number: 20080073201
    Abstract: The present invention relates to improved processes to recover acetonitrile from a diluted aqueous low grade acetonitrile feedstock.
    Type: Application
    Filed: October 28, 2004
    Publication date: March 27, 2008
    Applicant: UCB, S.A.
    Inventors: August Van Gysel, Frans Soeterbroeck, Geert Vermeulen
  • 2,6-Quinolinyl And 2,6-Naphthyl Derivatives, Processes For Preparing Them And Their Uses As Vla-4 Inhibitors
    Publication number: 20080064720
    Abstract: The present invention concerns 2,6-quinolinyl and 2,6-naphthyl derivatives of formula (I), processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals for the treatment of VLA-4 dependent inflammatory diseases such as for example asthma, allergic rhinitis, sinusitis, conjunctivitis, food allergy, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and atherosclerosis. Formula (I): wherein X is N or CH.
    Type: Application
    Filed: April 15, 2003
    Publication date: March 13, 2008
    Applicant: UCB, S.A.
    Inventors: Marie-Agnes Lassoie, Laurent Knerr, Theirry Demaude, Francoise De Laveleye-Defais, Thierry Kogej, Luc Quere, Sylvain Routier, Gerald Guillaumet
  • NOVEL PHARMACEUTICAL COMPOSITIONS COMPRISING LEVETIRACETAM
    Publication number: 20080014271
    Abstract: The present invention relates to pharmaceutical compositions comprising levetiracetam as active ingredient, the invention relates specifically to a prolonged release formulation.
    Type: Application
    Filed: March 2, 2007
    Publication date: January 17, 2008
    Applicant: UCB, S.A.
    Inventors: Caroline Goffin, Michael Boonen
  • NOVEL PHARMACEUTICAL COMPOSITIONS COMPRISING LEVETIRACETAM
    Publication number: 20080014264
    Abstract: The present invention relates to a pharmaceutical composition comprising levetiracetam as active ingredient, the invention relates specifically to a prolonged release formulation.
    Type: Application
    Filed: March 2, 2007
    Publication date: January 17, 2008
    Applicant: UCB, S.A.
    Inventors: Caroline Goffin, Monique Berwaer, Michael Boonen, Michel Deleers, Domenico Fanara
  • PROCESS FOR THE PREPARATION OF 2-OXO-1-PYRROLIDINE DERIVATIVES
    Publication number: 20080009638
    Abstract: The present invention relates to alternative processes for the preparation of 2-oxo-1-pyrrolidine derivatives of formula (I) Particularly, the present invention relates to alternative processes for the synthesis of levetiracetam, brivaracetam and seletracetam.
    Type: Application
    Filed: December 19, 2006
    Publication date: January 10, 2008
    Applicant: UCB S.A.
    Inventors: John Surtees, Didier Bouvy, Antoine Thomas, Yves Combert, Michael Frank, Gunther Schmidt, Guy Duchene
  • Benzoxazolone Derivatives, Processes For Preparing Them And Their Uses
    Publication number: 20070299118
    Abstract: The present invention relates to benzoxazolone derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals, in the treatment of movement disorders, in particular in Parkinson's disease.
    Type: Application
    Filed: May 24, 2005
    Publication date: December 27, 2007
    Applicant: UCB, S.A.
    Inventors: Jean-Philippe Starck, Benoit Kenda
  • Pharmaceutical Composition Of Piperazine Derivatives
    Publication number: 20070275974
    Abstract: The present invention relates to a liquid composition containing an active substance belonging to the family of substituted benzhydryl piperazines with reduced amounts of preservatives.
    Type: Application
    Filed: July 6, 2005
    Publication date: November 29, 2007
    Applicant: UCB, S.A.
    Inventors: Domenico Fanara, Jean Scouvart, Claire Poulain, Michel Deleers
  • Imidazole derivatives, processes for preparing them and their uses
    Patent number: 7244747
    Abstract: The present invention relates to imidazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
    Type: Grant
    Filed: November 30, 2004
    Date of Patent: July 17, 2007
    Assignee: UCB, S.A.
    Inventors: Benoit Kenda, Philippe Michel, Yannick Quesnel