Abstract: The present invention provides an engineered T cell receptor (TCR) comprising at least one of the following amino acid residues: L96 of the ? chain; R9 of the ? chain; Y10 of the ? chain; T24 of the ? chain; V19 of the ? chain; T20 of the ? chain; M50 of the ? chain; T5 of the ? chain; Q8 of the ? chain; S86 of the ? chain; F39 of the ? chain; D55 of the ? chain; R43 of the ? chain; A66 of the ? chain; V19 of the ? chain; L21 of the ? chain; L103 of the ? chain; T3 of the ? chain; S7 of the ? chain; P9 of the ? chain; M11 of the ? chain; A16 of the ? chain; T18 of the ? chain; L21 of the ? chain; S22 of the ? chain; D26 of the ? chain; F40 of the ? chain; S47 of the ? chain; R48 of the ? chain; Q49 of the ? chain; I51 of the ? chain; L52 of the ? chain; V53 of the ? chain; T67 of the ? chain; E68 of the ? chain; N74 of the ? chain; F76 of the ? chain; N79 of the ? chain; Q81 of the ? chain; A83 of the ? chain; K90 of the ? chain; S92 of the ? chain; D93 of the ? chain; and M101 of the ? chain; wherein the at