Patents Assigned to UFC Limited
  • Process for making morphine-6-glucuronide and its analogues using haloglucuronate ester intermediates
    Patent number: 6642366
    Abstract: A process for manufacturing morphine-6-glucuronide and related compounds of the general structure of Formula 1: wherein optionally substituted morphine is conjugated with an optionally substituted member of a new class of intermediates, namely, 1-haloglucuronate esters, in the presence of iodine or an iodinium compound. The conjugation may be followed by conversion of R1 of Formula 1 into hydrogen and/or the removal of the ester groups from the glucuronic residue at R2 of Formula 1.
    Type: Grant
    Filed: June 7, 2002
    Date of Patent: November 4, 2003
    Assignee: UFC Limited
    Inventors: Feodor Scheinmann, Andrew Valentine Stachulski, John Ferguson, Jane Louise Law