Patents Assigned to Ukko Inc.
  • MODIFIED LOW MOLECULAR WEIGHT GLUTENIN SUBUNIT AND USES THEREOF
    Publication number: 20250074955
    Abstract: A de-epitoped low molecular weight glutenin subunits (LMW-GS) is provided. Methods of generating same and uses thereof are also provided. A de-epitoped LMW-GS may be beneficial for a subject suffering from gluten sensitivities, such as a celiac disease patient. A de-epitoped LMW-GS may be comprised in food or beverage products such as bread, cake, cookie, noodle, pasta, or pizza.
    Type: Application
    Filed: January 10, 2023
    Publication date: March 6, 2025
    Applicant: Ukko Inc.
    Inventors: Yanay OFRAN, Moshe BEN DAVID, Orly MARCU GARBER, Shiri ZAKIN, Assaf BIRAN, Anna CHUPRIN
  • HYPOALLERGENIC PEANUT ALLERGENS, PRODUCTION AND USE THEREOF
    Publication number: 20240390485
    Abstract: In one embodiment, the present disclosure provides hypoallergenic peanut allergens Ara h 1 or Ara h 2 variants lacking at least one epitope recognized by anti-Ara h 1 antibodies or anti-Ara h 2 antibodies, thereby having reduced or abolished antibody binding to the peanut allergen variants. These hypoallergenic peanut allergen variants may be used in methods of inducing desensitization to peanuts in a subject allergic to peanuts.
    Type: Application
    Filed: August 2, 2022
    Publication date: November 28, 2024
    Applicant: Ukko Inc.
    Inventors: Yanay OFRAN, Moshe BEN DAVID, Orly MARCU GARBER, Si NAFTALY KIROS, Gil DIAMANT, Almog BREGMAN COHEN, Maayan KORMAN, Anna CHUPRIN, Zohar BIRON SOREK, Lior ROSENFELD SHLAMKOVICH, Etai ROTEM, Yair GAT
  • HYPOALLERGENIC PEANUT ALLERGENS, PRODUCTION AND USE THEREOF
    Publication number: 20240117020
    Abstract: In one embodiment, the present disclosure provides a combination of recombinant Ara h 1 and Ara h 2 variant polypeptides lacking at least one epitope recognized by anti-Ara h 1 antibodies and anti-Ara h 2 antibodies, respectively, thereby having reduced or abolished antibody binding to the peanut allergen. These peanut allergen variants may be used in methods of treating subjects allergic to peanuts and reducing the severity of their allergy.
    Type: Application
    Filed: November 29, 2023
    Publication date: April 11, 2024
    Applicant: Ukko Inc.
    Inventors: Yanay OFRAN, Moshe BEN DAVID, Orly MARCU GARBER, Si NAFTALY KIROS, Gil DIAMANT, Almog BREGMAN COHEN, Maayan KORMAN, Anna CHUPRIN, Zohar BIRON SOREK, Lior ROSENFELD SHLAMKOVICH, Etai ROTEM, Yair GAT
  • MODIFIED HIGH MOLECULAR WEIGHT GLUTENIN SUBUNIT AND USES THEREOF
    Publication number: 20230416314
    Abstract: A de-epitoped high molecular weight (HMW) glutenin is provided. Methods of generating same, and uses thereof are also provided.
    Type: Application
    Filed: November 24, 2021
    Publication date: December 28, 2023
    Applicant: Ukko Inc.
    Inventors: Yanay OFRAN, Assaf BIRAN, Shiri ZAKIN, Moshe BEN-DAVID, Anna CHUPRIN, Orly MARCU GARBER
  • DE-EPITOPED ALPHA GLIADIN AND USE OF SAME FOR THE MANAGEMENT OF CELIAC DISEASE AND GLUTEN SENSITIVITY
    Publication number: 20220251148
    Abstract: A de-epitoped alpha gliadin is provided. Methods of generating same and uses thereof are also provided.
    Type: Application
    Filed: July 2, 2020
    Publication date: August 11, 2022
    Applicant: Ukko Inc.
    Inventors: Yanay OFRAN, Moshe BEN-DAVID, Assaf BIRAN, Shiri ZAKIN, Orly MARCU GARBER, Anna CHUPRIN
  • METHODS OF DE-EPITOPING WHEAT PROTEINS AND USE OF SAME FOR THE TREATMENT OF CELIAC DISEASE
    Publication number: 20210292381
    Abstract: A method for identifying an epitope of a wheat T cell immunogen is provided. The method comprises identifying an epitope on the wheat T cell immunogen for the ability to bind a major histocompatibility complex (MHC) class II, thereby identifying the epitope of a wheat T cell immunogen.
    Type: Application
    Filed: July 4, 2019
    Publication date: September 23, 2021
    Applicant: Ukko Inc.
    Inventors: Yanay OFRAN, Moshe BEN-DAVID, Assaf BIRAN, Shiri ZAKIN, Orly MARCU
  • METHODS FOR IDENTIFYING AND DE-EPITOPING ALLERGENIC POLYPEPTIDES
    Publication number: 20200124615
    Abstract: Provided herein are methods for identifying one or more epitopes on allergenic polypeptides. Also provided herein are methods for de-epitoping allergenic polypeptides.
    Type: Application
    Filed: December 28, 2017
    Publication date: April 23, 2020
    Applicant: Ukko Inc.
    Inventor: Yanay OFRAN