Abstract: A combined composition comprising an anti-4-1BB monoclonal antibody and chemotherapeutic anti-cancer agent for preventing and treating cancer disease. Provides a pharmaceutical composition comprising the combined mixture of anti-4-1BB antibody and chemotherapeutic anti-cancer agent enhancing the specific immune response to cancer and killing cancer cell for treating or preventing cancer disease as an effective ingredient, together with a pharmaceutically acceptable carrier.

Abstract: The present invention is related to a pharmaceutical composition comprising anti-4-1BB antibody as an active ingredient in an amount effective to preventing and treating rheumatic arthritic diseases by proliferating CD1 Ic+CD8+ T cells and inducing CD4+ T cell suppression, together with a pharmaceutically acceptable carrier. The composition of the present invention is not toxic in general immune response and can remarkably alleviate progressive, inflammatory or auto-immune arthritis symptoms by inducing antigen-specific immune suppression. Accordingly, it can be useful in the prevention or treatment of arthritic diseases without adverse response.