Abstract: The present disclosure provides compounds, compositions, and methods, wherein the compounds include a modified cholic acid or a cholic acid component and at least a second component in which the second component is conjugated to the modified cholic acid or cholic acid having the following structure: In certain instances, the conjugate compound provides reduced cytotoxicity, greater efficacy, and a more robust MOA (e.g., the entry into a cell is more facile or multiple modes of action occur) compared to the non-conjugated component alone. In certain instances, the second component such as biotin is covalently linked to the modified cholic acid or cholic acid.

Abstract: A latch assembly comprising a tilt latch mechanism and a sash lock mechanism for a vinyl window that is slidable and tiltable. The latch assembly comprises a lever movable among a first, a second, and a third position to adjust the assembly among a respective locked, unlocked, and tiltable position. In the locked position, a portion of a rotor engages a keeper to prevent the window from being able to move. In the unlocked position, the window is movable upward and downward along the rails of the window frame. In the tiltable position, the window may be tilted on an axis to allow for cleaning the outer portion of the window from inside the house.