Abstract: Heteroaryl sulfonyl compounds and compositions that have a KRAS Recognition Moiety bound to an electrophile for the selective covalent modification of KRAS, for example a mutant KRAS, to treat KRAS-mediated disorders are described.
Type:
Application
Filed:
September 5, 2023
Publication date:
December 21, 2023
Applicant:
Umbra Therapeutics, Inc.
Inventors:
Guillaume Barbe, Mark George Sauliner, William John Greenlee, Soumya Ray
Abstract: Heteroaryl sulfonyl compounds and compositions that have a CDK2 Recognition Moiety bound to an electrophile for the selective covalent modification of CDK2 to treat CDK2-mediated disorders are described.
Type:
Application
Filed:
September 5, 2023
Publication date:
December 21, 2023
Applicant:
Umbra Therapeutics, Inc.
Inventors:
Guillaume Barbe, Mark George Sauliner, William John Greenlee, Soumya Ray