Abstract: A method for controlling cholesterol metabolism in a host, a screening assay for agents that can control cholesterol metabolism, and the agents that may be identified are practiced and determined in relation to the expression of PLTP in HepG2 cells and a clone from these cells, designated HepG2/PLTPpLuc. Particular agents that are covered comprise camptothecin, topotecan, derivatives thereof, metabolic byproducts thereof and small molecule mimics thereof.
Type:
Grant
Filed:
May 15, 2002
Date of Patent:
July 18, 2006
Assignee:
UMDNJ (Univ of Medicine & Dentist. of NJ)