Abstract: Described herein are a wearable apparatus and methods for detecting the presence of a targeted substance in a liquid. For example, the wearable apparatus can be a fingernail that detects illicit drugs in a beverage. The wearable apparatus comprises a detection layer comprising an indicator that is configured to display a signal upon the detection of an interaction with the targeted substance. In some examples, the wearable apparatus can include a lateral flow assay.

Abstract: Described herein are apparatus and methods for detecting substances of abuse or other analytes in liquids. For example, the apparatus and methods described herein can be used for real-time detection of analytes, such as substances of abuse. The methods comprise providing a detection area comprising a chromatographic membrane capable of receiving the liquid and allowing for migration of the liquid, the chromatographic membrane comprising an anti-analyte antibody-particle conjugate, an analyte-conjugate protein at a test line; exposing at least the first location of the apparatus to the liquid; and determining whether an interaction between the analyte-conjugate protein and the liquid occurs to detect the presence of the analyte. The chromatographic membrane may further comprise an anti-species antibody at a control line.

Abstract: Described herein are apparatus and methods for detecting substances of abuse or other analytes in liquids. For example, the apparatus and methods described herein can be used for real-time detection of analytes, such as substances of abuse. The methods comprise providing a detection area comprising a chromatographic membrane capable of receiving the liquid and allowing for migration of the liquid, the chromatographic membrane comprising an anti-analyte antibody-particle conjugate, an analyte-conjugate protein at a test line; exposing at least the first location of the apparatus to the liquid; and determining whether an interaction between the analyte-conjugate protein and the liquid occurs to detect the presence of the analyte. The chromatographic membrane may further comprise an anti-species antibody at a control line.

Abstract: Described herein are a wearable apparatus and methods for detecting the presence of a targeted substance in a liquid. For example, the wearable apparatus can be a fingernail that detects illicit drugs in a beverage. The wearable apparatus comprises a detection layer comprising an indicator that is configured to display a signal upon the detection of an interaction with the targeted substance. In some examples, the wearable apparatus can include a lateral flow assay.