Patents Assigned to UNDERDOG PHARMACEUTICALS, INC.
  • Cyclodextrin dimers, compositions thereof, and uses thereof
    Patent number: 11279774
    Abstract: A new class of synthetic cyclodextrin dimers is described. Exemplary cyclodextrin dimers can treat atherosclerotic plaques by targeting various forms cholesterol both intracellularly and extracellularly. Also provided are methods of depleting atherosclerotic plaques of cholesterol, cholesterol esters, 7-ketocholesterol and 7-ketocholesterol esters by treatment with such cyclodextrins. Further described are subclasses of dimers that have high specificity for 7-ketocholesterol.
    Type: Grant
    Filed: January 3, 2020
    Date of Patent: March 22, 2022
    Assignee: UNDERDOG PHARMACEUTICALS, INC.
    Inventors: Matthew S. O'Connor, Milo Malanga, Michael Kope, Christina A. T. M. B. Tom, Amelia M. Anderson