Patents Assigned to Undivided Trinity of Queen Elizabeth near Dublin
  • Patent number: 11092550
    Abstract: The present invention provides a method of using Raman spectroscopy for identification of low grade cervical cytology cases likely to progress to high grade/cancer. The Applicant has found that high quality Raman spectra can be successfully acquired from morphologically normal appearing cells from negative, LSIL and HSIL Thinprep® specimens and different grades of cervical pre-cancer can be separated with good sensitivities and specificities. Raman spectroscopy can further identify different categories of the LSIL cases i.e., whether they are likely to regress to negative or progress to HSIL cytology.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: August 17, 2021
    Assignees: Technological University Dublin, The Provost, Fellows, Foundation Scholars, and the Other Members of Board, of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin
    Inventors: Shiyamala Duraipandian, Fiona Lyng, Damien Traynor, John O'Leary, Cara Martin, Padraig Kearney
  • Patent number: 10987220
    Abstract: A heart valve therapeutic device (1) has an elongate anchor (7) wherein the anchor has a stiffness to hold its shape and location to support the valve element. The anchor may have a stylet or a shaped or stiff collar (70) arranged to provide a desired shape to the anchor (7) and it may be lockable. A prosthetic valve element (15) has leaflets (17) and is supported on the anchor by coupler (16, 50) at a desired location. There is an actuator for changing relative axial position of the proximal and distal couplers (16, 50) on the anchor. The anchor stiffness may be sufficient to provide sufficient support to resist axial forces from the ventricle in use without necessarily having a fixing element engaging heart tissue. The prosthetic leaflets (240) may extend proximally and radially outwardly, so that there is excellent co-apting of the native leaflets (NL) against the prosthetic leaflets (240).
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: April 27, 2021
    Assignee: The Provost, Fellows Foundation Scholars, and the Other Members of the Board, Of The College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin (TCD)
    Inventor: Martin Quinn
  • Patent number: 10952854
    Abstract: A heart valve therapeutic device (1) comprises a coaptation assist valve (20) comprising a conduit (2) with an outer surface (3) for coaption with the native leaflets, and a prosthetic flow valve (5) mounted within the conduit (2) to allow one-way flow through the conduit (2). Support for the coaptation assist valve (20) is provided by a support (10) for positioning the conduit (2) across the native leaflets, and connectors (15) attaching the conduit (2) to the support (10).
    Type: Grant
    Filed: July 30, 2020
    Date of Patent: March 23, 2021
    Assignee: The Provost, Fellows, Foundation Scholars and the Other Members Of Board, of the College of the Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin (TCD)
    Inventors: Paul Heneghan, Bruce Murphy, Lucy O'Keeffe, Martin Quinn, Conor Quinn
  • Patent number: 10765084
    Abstract: A seed coating composition comprising a mixture of a fungal root endophyte isolated from a root of the plant found in low-nutrient, drought-stressed or multiply-stressed conditions and a carrier medium for application of said composition to a target seed, wherein the endophyte is characterised in having a nuclear ribosomal internal transcribed spacer (nr ITS) with at least a 90% sequence identity to any one of SEQ ID NOs: 3 to 15.
    Type: Grant
    Filed: August 29, 2015
    Date of Patent: September 8, 2020
    Assignees: The Provost, Fellows, Foundation Scholars & the Other Members of Board, of the College of the Holy & Undivided Trinity of Queen Elizabeth, Near Dublin, University College Dublin, National University of Ireland, Dublin
    Inventors: Brian Murphy, Trevor Hodkinson, Fiona Doohan
  • Patent number: 10682231
    Abstract: A heart valve therapeutic device (1) has an elongate anchor (7) wherein the anchor has a stiffness to hold its shape and location to support the valve element. The anchor may have a stylet or a shaped or stiff collar (70) arranged to provide a desired shape to the anchor (7) and it may be lockable. A prosthetic valve element (15) has leaflets (17) and is supported on the anchor by coupler (16, 50) at a desired location. There is an actuator for changing relative axial position of the proximal and distal couplers (16, 50) on the anchor. The anchor stiffness may be sufficient to provide sufficient support to resist axial forces from the ventricle in use without necessarily having a fixing element engaging heart tissue. The prosthetic leaflets (240) may extend proximally and radially outwardly, so that there is excellent co-apting of the native leaflets (NL) against the prosthetic leaflets (240).
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: June 16, 2020
    Assignee: The Provost, Fellows Foundation Scholars, And The Other Members of the Board, Of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin (TCD)
    Inventor: Martin Quinn
  • Patent number: 10538487
    Abstract: The present invention provides for certain sulfonyl ureas and related compounds which have advantageous properties and show useful activity in the inhibition of activation of the NLRP3 inflammasome. Such compounds are useful in the treatment of a wide range of disorders in which the inflammation process, or more specifically the NLRP3 inflammasome, have been implicated as being a key factor.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: January 21, 2020
    Assignees: THE UNIVERSITY OF QUEENSLAND, THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
    Inventors: Luke O'Neill, Rebecca Coll, Matthew Cooper, Avril Robertson, Kate Schroder
  • Patent number: 10383729
    Abstract: A heart valve therapeutic device has an elongate anchor wherein the anchor has a stiffness to hold its shape and location to support the valve element. The anchor may have a stylet or a shaped or stiff collar arranged to provide a desired shape to the anchor and it may be lockable. A prosthetic valve element has leaflets and is supported on the anchor by coupler at a desired location. There is an actuator for changing relative axial position of the proximal and distal couplers on the anchor. The anchor stiffness may be sufficient to provide sufficient support to resist axial forces from the ventricle in use without necessarily having a fixing element engaging heart tissue. The prosthetic leaflets may extend proximally and radially outwardly, so that there is excellent co-apting of the native leaflets (NL) against the prosthetic leaflets.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: August 20, 2019
    Assignee: The Provost, Fellows Foundation Scholars, and The Other Members of the Board, of the College of The Holy and Undivided Trinity of Queen Elizabeth Near Dublin (TCD)
    Inventor: Martin Quinn
  • Patent number: 10362488
    Abstract: Provided a method and system for computing a bandwidth requirement for a cellular operator from shared spectrum in a cellular network, the shared spectrum comprising at least one shared spectrum class which is accessible by multiple entities, the method comprising: computing an average user throughput in the cellular network; comparing the average user throughput to a target minimum average user throughput, taking into account an average percentage of users within coverage and a coverage probability threshold; and based on the comparison, computing an additional bandwidth requirement from the at least one shared spectrum class.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: July 23, 2019
    Assignee: THE PROVOST, FELLOWS, FOUNDATION SCHOLARS AND THE OTHER MEMBERS OF THE BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
    Inventors: Jasmina McMenamy, Irene Macaluso, Linda Doyle
  • Patent number: 10304937
    Abstract: A process for exfoliating untreated 3-dimensional material to produce a 2-dimensional material, said process comprising the steps of mixing the untreated 3-dimensional material in a liquid to provide a mixture; applying shear force to said mixture to exfoliate the 3-dimensional material and produce dispersed exfoliated 2-dimensional material in solution; and removing the shear force applied to said mixture, such that the dispersed exfoliated 2-dimensional material remains free and unaggregated in solution.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 28, 2019
    Assignee: The Provost, Fellows, Foundation Scholars, and the Other Members of Board, of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin
    Inventors: Jonathan Coleman, Keith Paton
  • Patent number: 10251604
    Abstract: A process for producing conductive composites, the process comprising the steps of soaking a polymer in an organic solvent and applying energy; soaking the polymer in a solution of conductive nano-material dispersed in an organic solvent:water mixture and applying energy, so that conductive nano-material is incorporated into the polymer structure; washing the conductive nano-material-incorporated polymer in deionized water and applying energy; and drying the washed conductive nano-material-incorporated polymer to produce the conductive composite, wherein the conductive composite incorporates conductive nano-material throughout the structure of the polymer without affecting the integrity of the properties of the polymer.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: April 9, 2019
    Assignee: The Provost, Fellows, Foundation Scholars, and the other Members of Board, of the College of the Holy and Undivided Trinity of Queen Elizabeth, near Dublin
    Inventors: Jonathan Coleman, Conor Boland, Umar Khan
  • Patent number: 10220102
    Abstract: An isolated nucleic acid sequence encoding the yeast NDI1 protein of SEQ ID NO: 542 or a functional variant thereof is described. The nucleic acid sequence comprises at least 50 codons which are codon optimized compared with the sequence of yeast NDI1 gene of SEQ ID NO: 1.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: March 5, 2019
    Assignee: THE PROVOST FELLOWS FOUNDATION SCHOLARS AND THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLD AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN TRINITY COLLEGE DUBLIN
    Inventors: Gwyneth Jane Farrar, Sophia Millington-Ward, Naomi Chadderton, Mathew Alan Carrigan, Paul Kenna
  • Patent number: 10106519
    Abstract: Provided herein are 3-phenyl-7-hydroxy-isocoumarin compounds which are MIF inhibitors; compositions comprising said inhibitors and methods for treating or preventing diseases associated with MIF.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: October 23, 2018
    Assignee: The Provost, Fellows, Foundation Scholars, and the Other Members of Board, of the College of the Holy and Undivided Trinity of Queen Elizabeth, Near Dublin
    Inventors: Seamas Donnelly, David Lloyd, Ciaran O'Reilly, Darren Fayne
  • Patent number: 10039488
    Abstract: The invention describes a system and method how tissue compression can be measured continuously in a non-contact way to provide a low cost, patient/user specific measurement system. The method may be used to inform existing and future pressure relief mattress systems. The invention may also be used for any application either in conjunction with another system or on its own to measure tissue compression. In another embodiment the invention can be used for measuring any type of compression of a compressible material, for example compression of viscoelastic foam or other materials. The invention may also be used to make inferences about the changes of blood flow at site of measurement.
    Type: Grant
    Filed: September 10, 2012
    Date of Patent: August 7, 2018
    Assignee: Provost, Fellows, Foundation Scholars and the other members of the Board of the College of the Holy and Undivided Trinity of Queen Elizabeth, near Dublin
    Inventors: Sonja Hermann, Richard Reilly
  • Patent number: 10029056
    Abstract: A system and method suitable for monitoring user technique of an inhaler device configured for delivery of a medicament is provided. The system may include a microphone adapted for sensing sound made during operation of the inhaler device and processing circuitry operable to process a data signal obtained from the microphone, wherein the data signal includes acoustic information sensed. The processing circuitry is adapted to determine inhalation and exhalation breath characteristics that occur during use, by analyzing the temporal and spectral components of the acoustic information sensed and processed to differentiate between an inhalation and an exhalation, based on both the temporal and spectral components. This information can be processed to determine user technique adherence to inhaler or respiratory device protocol. The analysis of temporal and spectral components can determine the impact of user technique errors on the quantity and the deposition of medicament delivered into the user's airways.
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: July 24, 2018
    Assignees: The Provost, Fellows, Foundation Scholars, & The Other Members of Board, of the College of the Holy & Undivided Trinity of Queen Elizabeth near Dublin, Royal College of Surgeons in Ireland
    Inventors: Richard Reilly, Richard Costello, Cian Hughes, Ehsan Chah, Isabelle Killane
  • Patent number: 9975860
    Abstract: Compounds and compositions are described which are useful especially for treatment of angiogenesis-related diseases or disorders such as neovascularisation of the eye, age-related macular degeneration, diabetic retinopathy or cancer.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: May 22, 2018
    Assignees: University College Dublin, National University of Ireland, Dublin, The Provost Fellows Foundation Scholars and the other members of the Board of the College of the Holy and Undivided Trinity of Queen Elizabeth, near Dublin
    Inventors: Breandan Kennedy, Alison Reynolds, Jacintha O'Sullivan, Andrew Douglas Baxter
  • Patent number: 9873717
    Abstract: The invention relates to a novel thyrotropin releasing hormone (TRH) receptor subtype in human central nervous system (CNS) that is pharmacologically distinct from the TRH receptor subtype in human pituitary. The invention provides a means to understand how the central actions of TRH are mediated and to isolate and characterize the novel receptor, as well as methods applicable to research and development of diagnostic and therapeutic applications in human CNS disorders.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: January 23, 2018
    Assignee: THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN
    Inventor: Julie Kelly
  • Patent number: 9815788
    Abstract: (E)-2-(2-Quinolin-2-yl-propenyl)-phenol, 2-Quinolin-2-yl-ylethynyl-phenol and salts thereof are useful as medicaments, especially for treatment of an angiogenesis-related disease or disorder.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: November 14, 2017
    Assignees: THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN, UNIVERSITY COLLEGE DUBLIN NATIONAL UNIVERSITY OF IRELAND, DUBLIN
    Inventors: Breandan Noel Kennedy, Alison Reynolds, Claire Kilty, Jacintha O'Sullivan, Andrew Douglas Baxter
  • Patent number: 9751760
    Abstract: The invention provides a process for exfoliating a 3-dimensional layered material to produce a 2-dimensional material, said process comprising the steps of mixing the layered material in a solvent to provide a mixture; applying energy, for example ultrasound, to said mixture, and removing the energy applied to the mixture, such that sedimentation of the 2-dimensional material out of solution as a weakly re-aggregated, exfoliated 2-dimensional material is produced. The invention provides a fast, simple and high yielding process for separating 3-dimensional layered materials into individual 2-dimensional layers or flakes, which do not strongly re-aggregate, without utilising hazardous solvents.
    Type: Grant
    Filed: June 28, 2013
    Date of Patent: September 5, 2017
    Assignee: The Provost, Fellows, Foundation Scholars, and the Other Members of Board of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin
    Inventors: Jonathan Coleman, Umar Khan
  • Patent number: 9706929
    Abstract: The present invention relates to an optical device for imaging and measuring characteristics of an objects surface shape, surface spectral reflectance and structure of sub-surface layers. In particular, the invention relates to imaging of topography of human skin and skin sub-surface layers and determination of concentration of skin constituents. The present invention has applications in areas such as skin care, dermatology, cosmetics, wound management and tricology. The imaging device of the invention significantly improves photometric stereo measurements by suppressing specular reflection and allows accurate determination of the surface shape. Consequently the device allows elimination of the influence of the shape and illumination conditions on spectral measurements and allows accurate measurement of skin constituents.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: July 18, 2017
    Assignee: The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth, Near Dublin
    Inventors: Roman Kantor, Guido Mariotto, Igor Shvets
  • Patent number: D818020
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: May 15, 2018
    Assignee: THE PROVOST, FELLOWS, FOUNDATION SCHOLARS AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
    Inventor: Conor McGinn