Abstract: The invention provides a novel peptide, and derivatives thereof, which is stable in aqueous solution and which stimulates proliferation and survival of endothelial cells and/or fibroblasts. The present peptide can be used at least to promote the S phase of the cell cycle, to stimulate production of extracellular matrix proteins, to reduce apoptosis, to inhibit production of reactive oxygen species and/or to reduce or prevent damage to cell integrity or morphology under stress conditions of serum deprivation.
Abstract: The present invention relates to the use of Ang-(1-7) and/or Ang-(1-7) receptor agonist and/or Ang (1-7) analogue in treating/restoring erectile dysfunction.
Type:
Application
Filed:
January 24, 2008
Publication date:
August 5, 2010
Applicants:
UNIVERSIDADE FEDERAL DE MINAS GERAIS- UFMG, BIOLAB SANUS FARMACÊUTICA LTDA., UNIÃO QUÍMICA FARMACÊUTICA NACIONAL, BIOSINTÉTICA FARMACÊUTICA LTDA.
Inventors:
Robson Augusto Souza dos Santos, Ruben Dario Sinisterra Millan, Frederic Jean Georges Frezard, Andrey Christian da Costa Goncalves, Rodrigo Araujo Fraga da Silva