Patents Assigned to Unibioscreen S.A.
  • 2? oxo-voruscharin and derivatives thereof
    Patent number: 7981875
    Abstract: Compounds and pharmaceutical compositions which include 2? oxo-voruscharin and derivatives are disclosed. The compounds and pharmaceutical compositions are useful in methods of treating cancer, particularly pancreatic cancer.
    Type: Grant
    Filed: December 13, 2007
    Date of Patent: July 19, 2011
    Assignees: Unibioscreen S.A., Universite Libre de Bruxelles
    Inventors: Eric Van Quaquebeke, Jean-Claude Braekman, Gentiane Simon, Pierre Guissou, Odile Germaine Nacoulma, Janique Dewelle, Francis Darro, Robert Kiss
  • Azonafide derivatives, methods for their production and pharmaceutical compositions therefrom
    Patent number: 7741337
    Abstract: The present invention is directed to azonafide derivatives obtained by reacting azonafide with aldehydes, acyl halides, thioacyl halides, monoisocyanates, isothiocyanates, sulfonyl halides, monohalogenoalkanes, monohalogenoalkenes or monohalogenoalkynes, and are useful as active ingredients of pharmaceutical compositions for the prevention and treatment of cell proliferative disorders, in particular several forms of cancer.
    Type: Grant
    Filed: November 9, 2006
    Date of Patent: June 22, 2010
    Assignee: Unibioscreen S.A.
    Inventors: Eric Van Quaquebeke, Jérôme Tuti, Laurent Van den Hove, Robert Kiss, Francis Darro
  • TARGETING OF ALPHA-1 OR ALPHA-3 SUBUNIT OF NA+, K+-ATPASE IN THE TREATMENT OF PROLIFERATIVE DISEASES
    Publication number: 20100068198
    Abstract: Targeting of select subunits of the Na+,K+-ATPase is described, and especially the alpha-1 subunit and/or the alpha-3 subunit. Antisense agents, agents capable of causing RNA interference that can reduce the expression of Na+,K+-ATPase, and antibodies and antibody fragments and derivatives specific for Na+,K+-ATPase are useful as reagents and pharmaceutical formulations for the treatment of proliferative diseases, such as tumours and cancers. Methods and kits are also described.
    Type: Application
    Filed: November 9, 2006
    Publication date: March 18, 2010
    Applicant: Unibioscreen S.A.
    Inventors: Tatjana Mijatovic, Eric Van Quaquebeke, Nancy Denève, Laurent Van den Hove, Francis Darro, Robert Kiss
  • Compositions and methods for treatment of esophageal cancer
    Publication number: 20090232907
    Abstract: Novel ureyl-substituted naphthalimide derivatives, pharmaceutically acceptable salts thereof and solvates thereof, are useful for making pharmaceutical compositions for the treatment of cell proliferative diseases such as cancer. The invention also provides methods of treating specific types of cancer such as prostate, esophageal, glioblastoma, gliosarcoma, NSCLC, head and neck, and breast with the compounds described herein alone and in combination with antineoplastic agents.
    Type: Application
    Filed: November 17, 2008
    Publication date: September 17, 2009
    Applicant: Unibioscreen S.A.
    Inventors: Eric Van Quaquebeke, Gentiane Simon, Mohamed El Yazidi, Jerome Tuti, Laurent Van Den Hove, Francis Darro, Robert Kiss
  • Compositions and methods for treatment of prostate and breast cancer
    Publication number: 20090221628
    Abstract: Novel ureyl-substituted naphthalimide derivatives, pharmaceutically acceptable salts thereof and solvates thereof, are useful for making pharmaceutical compositions for the treatment of cell proliferative diseases such as cancer. The invention also provides methods of treating specific types of cancer such as prostate, esophageal, glioblastoma, gliosarcoma, NSCLC, head and neck, and breast with the compounds described herein alone and in combination with antineoplastic agents.
    Type: Application
    Filed: November 17, 2008
    Publication date: September 3, 2009
    Applicant: Unibioscreen S.A.
    Inventors: Eric Van Quaquebeke, Gentiane Simon, Mohamed El Yazidi, Jerome Tuti, Laurent Van Den Hove, Francis Darro, Robert Kiss
  • 5-Urea Substituted Naphthalimide Derivatives, Methods of Production and Pharmaceutical Compositions for Treating Cancer
    Publication number: 20090118321
    Abstract: Novel ureyl-substituted naphthalimide derivatives, pharmaceutically acceptable salts thereof and solvates thereof, are useful for making pharmaceutical compositions for the treatment of cell proliferative diseases such as cancer. The invention also provides methods for making such derivatives through hydrolysis of known compounds.
    Type: Application
    Filed: May 7, 2007
    Publication date: May 7, 2009
    Applicant: Unibioscreen S.A.
    Inventors: Eric Van Quaquebeke, Gentiane Simon, Mohamed El Yazidi, Jerome Tuti, Laurent Van den Hove, Francis Darro, Robert Kiss
  • Azonafide Derivatives, Methods for Their Production and Pharmaceutical Compositions Therefrom
    Publication number: 20080292585
    Abstract: Azonafide derivatives are obtained by reacting azonafide with aldehydes, acyl halides, thioacyl halides, monoisocyanates, isothiocyanates, sulfonyl halides, monohalogenoalkanes, monohalogenoalkenes or monohalogenoalkynes, and are useful as active ingredients of pharmaceutical compositions for the prevention and treatment of cell proliferative disorders, in particular several forms of Cancer.
    Type: Application
    Filed: November 9, 2006
    Publication date: November 27, 2008
    Applicant: UNIBIOSCREEN S.A.
    Inventors: Eric Van Quaquebeke, Jerome Tuti, Laurent Van den Hove, Robert Kiss, Francis Darro
  • 2" OXO-VORUSCHARIN AND DERIVATIVES THEREOF
    Publication number: 20080261935
    Abstract: Compounds and pharmaceutical compositions which include 2? oxo-voruscharin and derivatives are disclosed. The compounds and pharmaceutical compositions are useful in methods of treating cancer, particularly pancreatic cancer.
    Type: Application
    Filed: December 13, 2007
    Publication date: October 23, 2008
    Applicants: Unibioscreen S.A., Universite Libre de Bruxelles
    Inventors: Eric Van Quaquebeke, Jean-Claude Braekman, Gentiane Simon, Pierre Guissou, Odile Germaine Nacoulma, Janique Dewelle, Francis Darro, Robert Kiss
  • 2? oxo-voruscharin and derivatives thereof
    Patent number: 7320971
    Abstract: 2? oxo-voruscharin compound and derivatives thereof are disclosed as well as pharmaceutical compositions which include 2? oxo-voruscharin compound or derivatives thereof. The disclosed 2? oxo-voruscharin compound and its derivatives are useful for cancer treatment. Methods of treating cancer using the disclosed compounds are also disclosed.
    Type: Grant
    Filed: October 9, 2003
    Date of Patent: January 22, 2008
    Assignee: Unibioscreen S.A.
    Inventors: Eric Van Quaquebeke, Jean-Claude Braekman, Gentiane Simon, Pierre Guissou, Odile Germaine Nacoulma, Janique Dewelle, Francis Darro, Robert Kiss