Abstract: Compositions comprising a polymer-based macroscopically homogeneous polymer alloy comprising a plurality of microcrystalline components dispersed within an amorphous component, which is biocompatible, bioerodable, substantially non-toxic, and excretable, or metabolized when introduced into a mammalian body. In preferred embodiments, malleable molded devices such as implants, films, drug delivery systems and the like, are comprised of the compositions. Methods of making such compositions by controlled cooling of the molten alloy are also described.
Abstract: Compositions useful for repairing osseous defects and healing of wounds and burns include particulate bioactive and biocompatible glass including 40 to 58% by weight silica, 10 to 32% by weight calcia, 10 to 32% by weight soda, 2 to 10% by weight phosphorus pentoxide and 0 to 8% by weight silver oxide. The particles have a size distribution of: less than 500 microns. Methods for repairing osseous defects, healing wounds and burns utilizing such compositions are also provided.
Abstract: Compositions useful for repairing osseous defects and healing of wounds and burns include particulate bioactive and biocompatible glass including 40 to 58% by weight silica, 10 to 32% by weight calcia, 10 to 32% by weight soda, 2 to 10% by weight phosphorus pentoxide and 0 to 8% by weight silver oxide. The particles have a size distribution of: less than 500 microns. Methods for repairing osseous defects, healing wounds and burns utilizing such compositions are also provided.
Abstract: Compositions useful for repairing osseous defects include particulate bioactive and biocompatible glass including 40 to 58% by weight silica, 10 to 320 by weight calcia, 10 to 320 by weight soda and 2 to 10% by weight phosphorus pentoxide. The particles have a size distribution of: 20 to 65% by weight, 50 microns to less than 297 microns; 20 to 45% by weight, 297 to less than 350 microns; and 15 to 40% by weight, 350 microns to less than 420 microns. Methods for repairing osseous defects utilizing such compositions are also provided.