Patents Assigned to Unichem Laboratories Limited
-
Publication number: 20220249385Abstract: The present disclosure provides an extended release composition of tofacitinib for oral administration, and methods of making the composition. The extended release composition employs a matrix drug core comprising tofacitinib or a pharmaceutically acceptable salt thereof and at least one release controlling polymer. The matrix drug core is surrounded by a soluble functional coating comprising at least one coating polymer and at least one pharmaceutically acceptable excipient.Type: ApplicationFiled: March 4, 2020Publication date: August 11, 2022Applicant: Unichem Laboratories LimitedInventors: Dhananjay SATHE, Bijay PADHI, Ankit BAHETI, Sachin BALI
-
Patent number: 10829450Abstract: The present disclosure is related to an improved and efficient process for preparation of (3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine which comprises: (a) N-acylation of 3-Amino-4-methyl pyridine; (b) Quarternization of 3-Acetylamino-4-methyl pyridine using benzyl halide; (c) Partial reduction of quarternized 3-Acetylamino-4-methyl pyridine by Sodium borohydride in Methanol or water; (d) Hydrolysis of partially reduced product to 1-Benzyl-4-methylpiperidin-3-one in presence of acid; (e) Reductive amination of 1-Benzyl-4-methylpiperidin-3-one using Methanolic methylamine in presence of Titanium(IV) isopropoxide in Methanol; (f) Resolution of 1-Benzyl-4-methylpiperidin-3-yl)-methylamine using Ditoluoyl (L) tartaric acid to get (3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine. The disclosure is also related to novel intermediates: wherein R, R? and X are as described in the specification.Type: GrantFiled: January 11, 2018Date of Patent: November 10, 2020Assignee: UNICHEM LABORATORIES LIMITEDInventors: Dhananjay G. Sathe, Arijit Das, Yogesh Subhash Patil, Nilesh L. Bonde, Ankush Sampat Kekan
-
Patent number: 10336753Abstract: The present invention refers to novel process for the preparation of Apixaban. Further, the invention also related to a process for the preparation of intermediate of Apixaban from very basic and cheap row material i.e. Aniline which is widely commercially available. The present invention provides process for preparation of Apixaban using a different sequence of synthetic steps and does not involve use of Ullmann reaction.Type: GrantFiled: August 22, 2018Date of Patent: July 2, 2019Assignee: Unichem Laboratories LimitedInventors: Dhananjay G. Sathe, Arijit Das, Yashwant Surve, Ramdas N. Ahire
-
Patent number: 10266507Abstract: A process for the preparation of Ranolazine (I) and its acid addition salts and the process for the preparation of compound of formula (7).Type: GrantFiled: March 4, 2016Date of Patent: April 23, 2019Assignee: UNICHEM LABORATORIES LIMITEDInventors: Dhananjay G. Sathe, Dnyaneshwar V. Gawas, Sanjay Bhaskar Chowkekar, Jotirling Ramling Mali
-
Patent number: 10208036Abstract: The present invention refers to novel process for the preparation of Apixaban. Further, the invention also related to a process for the preparation of intermediate of Apixaban from very basic and cheap row material i.e. Aniline which is widely commercially available. The present invention provides process for preparation of Apixaban using a different sequence of synthetic steps and does not involve use of Ullmann reaction.Type: GrantFiled: September 6, 2017Date of Patent: February 19, 2019Assignee: Unichem Laboratories LimitedInventors: Dhananjay G. Sathe, Arijit Das, Yashwant Surve, Ramdas N. Ahire
-
Patent number: 10118924Abstract: The present invention refers to novel process for the preparation of Apixaban. Further, the invention also related to a process for the preparation of intermediate of Apixaban from very basic and cheap row material i.e. Aniline which is widely commercially available. The present invention provides process for preparation of Apixaban using a different sequence of synthetic steps and does not involve use of Ullmann reaction.Type: GrantFiled: September 6, 2017Date of Patent: November 6, 2018Assignee: Unichem Laboratories LimitedInventors: Dhananjay G. Sathe, Arijit Das, Yashwant Surve, Ramdas N. Ahire
-
Patent number: 10034882Abstract: The present invention relates to Orally Disintegrating Tablets (ODT) of Tofacitinib and its pharmaceutically acceptable salts and the process to produce the ODT. The invention further relates to ODTs comprising Tofacitinib and its pharmaceutically acceptable salts, at least one sweetening agent, at least one disintegrant and optionally other excipients. The weight of the Orally Disintegrating tablets is 200 mg or less. The invention further relates to Orally Disintegrating Tablets of Tofacitinib Citrate.Type: GrantFiled: June 24, 2016Date of Patent: July 31, 2018Assignee: Unichem Laboratories LimitedInventors: Saurabh Gupta, Saiesh P. Phaldesai, Nsk. Senthil Kumar, Milind Vinayak Sathe
-
Patent number: 9951012Abstract: The present invention is related to an improved and efficient process for preparation of (3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine which comprises: (a) N-acylation of 3-Amino-4-methyl pyridine; (b) Quarternization of 3-Acetylamino-4-methyl pyridine using benzyl halide; (c) Partial reduction of quarternized 3-Acetylamino-4-methyl pyridine by Sodium borohydride in Methanol or water; (d) Hydrolysis of partially reduced product to 1-Benzyl-4-methylpiperidin-3-one in presence of acid; (e) Reductive amination of 1-Benzyl-4-methylpiperidin-3-one using Methanolic methylamine in presence of Titanium(IV) isopropoxide in Methanol; (f) Resolution of 1-Benzyl-4-methylpiperidin-3-yl)-methylamine using Ditoluoyl (L) tartaric acid to get (3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine. The invention is also related to novel intermediates: wherein R, R? and X are as described in the specification.Type: GrantFiled: December 2, 2014Date of Patent: April 24, 2018Assignee: UNICHEM LABORATORIES LIMITEDInventors: Dhananjay G. Sathe, Arijit Das, Yogesh Subhash Patil, Nilesh L. Bonde, Ankush Sampat Kekan
-
Patent number: 9908881Abstract: The present invention refers to novel process for the preparation of Apixaban. Further, the invention also related to a process for the preparation of intermediate of Apixaban from very basic and cheap row material i.e. Aniline which is widely commercially available. The present invention provides process for preparation of Apixaban using a different sequence of synthetic steps and does not involve use of Ullmann reaction.Type: GrantFiled: September 30, 2016Date of Patent: March 6, 2018Assignee: Unichem Laboratories LimitedInventors: Dhananjay G Sathe, Arijit Das, Yashwant Surve, Ramdas N. Ahire
-
Patent number: 9902717Abstract: The present invention relates to a process for the preparation of Azilsartan Medoxomil Potassium. The invention further relates to novel highly crystalline polymorph of Azilsartan Medoxomil Potassium and composition comprising it. The invention provides thermostable highly crystalline polymorph of Azilsartan Medoxomil Potassium and process to produce a composition comprising the novel highly crystalline polymorph of Azilsartan Medoxomil Potassium.Type: GrantFiled: March 21, 2016Date of Patent: February 27, 2018Assignee: UNICHEM LABORATORIES LIMITEDInventors: Dhananjay G. Sathe, Dnyaneshwar V. Gawas, Sashikant D. Metkar
-
Publication number: 20180044307Abstract: A process for the preparation of Ranolazine (I) and its acid addition salts and the process for the preparation of compound of formula (7).Type: ApplicationFiled: March 4, 2016Publication date: February 15, 2018Applicant: UNICHEM LABORATORIES LIMITEDInventors: Dhananjay G. SATHE, Dnyaneshwar V. GAWAS, Sanjay Bhaskar KEKAR, Jotirling Ramling MALI
-
Publication number: 20170304307Abstract: The present invention relates to Orally Disintegrating Tablets (ODT) of Tofacitinib and its pharmaceutically acceptable salts and the process to produce the ODT. The invention further relates to ODTs comprising Tofacitinib and its pharmaceutically acceptable salts, at least one sweetening agent, at least one disintegrant and optionally other excipients. The weight of the Orally Disintegrating tablets is 200 mg or less. The invention further relates to Orally Disintegrating Tablets of Tofacitinib Citrate.Type: ApplicationFiled: June 24, 2016Publication date: October 26, 2017Applicant: Unichem Laboratories LimitedInventors: Saurabh Gupta, Saiesh P. Phaldesai, NSK. Senthil Kumar, Milind Vinayak Sathe
-
Publication number: 20170197951Abstract: The present invention relates to a process for the preparation of Azilsartan Medoxomil Potassium. The invention further relates to novel highly crystalline polymorph of Azilsartan Medoxomil Potassium and composition comprising it. The invention provides thermostable highly crystalline polymorph of Azilsartan Medoxomil Potassium and process to produce a composition comprising the novel highly crystalline polymorph of Azilsartan Medoxomil Potassium.Type: ApplicationFiled: March 21, 2016Publication date: July 13, 2017Applicant: Unichem Laboratories LimitedInventors: Dhananjay G. Sathe, Dnyaneshwar V. Gawas, Sashikant D. Metkar