Patents Assigned to Uniformed Services University of Health Sciences
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Patent number: 8741869Abstract: A substantially pure or isolated oligodeoxynucleotide of at least 10 nucleotides is disclosed, wherein the oligodeoxynucleotide comprised a sequence represented by either formula: 5? N1N2N3T-CpG-WN4N5N6 3? wherein the CpG motif is unmethylated, W is A or T, and N1, N2, N3, N4, N5, and N6 are nucleotides, or the formula: 5? RY-CpG-RY 3? wherein the central CpG motif is unmethylated, R is A or G, and Y is C or T, as well as an oligodeoxynucleotide delivery complex and a pharmacological composition comprising the present inventive oligodeoxynucleotide, and a method of inducing an immune response by administering the present inventive oligodeoxynucleotide to a host. In some embodiments, the oligodeoxynucleotide includes the nucleic acid sequences set forth as SEQ ID NO: 137.Type: GrantFiled: February 5, 2013Date of Patent: June 3, 2014Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, Uniformed Services University of the Health Sciences, an institution of higher learning within the Department of DefenseInventors: Dennis M. Klinman, Ken J. Ishii, Daniela Verthelyi, James J. Mond
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Patent number: 8518652Abstract: Methods/reagents for detecting and/or treating cancers or potential cancers are disclosed. In one embodiment, methods and reagents for detecting truncated forms of P2X7 protein in cells are described. In one embodiment, methods and reagents for increasing the amount and/or activity of full-length P2X7 in cells are described. In one embodiment, methods and reagents for decreasing the amount and/or activity of truncated P2X7 in cells are described.Type: GrantFiled: April 28, 2010Date of Patent: August 27, 2013Assignees: Uniformed Services University of the Health Sciences, an Institution of Higher Learning within the Department of Defense., The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.Inventors: George Gorodeski, Ying-Hong Feng, Xin Li
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Patent number: 7738944Abstract: The present invention includes a method and apparatus for high sensitivity whole body scanning using MR imaging. The invention includes acquiring MR data as the patient moves through the iso-center of the magnet while providing interactive control for the operator to change scan parameters and table motion and direction. The technique allows efficient whole body scanning for fast screening of abnormalities while allowing operator control during the screening process to interrupt table motion and redirect the speed and direction of the table while also allowing control over the acquisition plane, number of sections imaged, inter-section spacing, and the scan location.Type: GrantFiled: April 19, 2005Date of Patent: June 15, 2010Assignees: General Electric Company, Uniformed Services University of Health Sciences, United States of America Department of DefenseInventors: Vincent B. Ho, Thomas K. F. Foo
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Patent number: 7658931Abstract: Mutant cholera holotoxins having single or double amino acid substitutions or insertions have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in antigenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.Type: GrantFiled: December 19, 2007Date of Patent: February 9, 2010Assignees: Wyeth Holdings Corporation, The United States of America, as represented by the Uniformed Services University of Health SciencesInventors: Bruce A. Green, Randall K. Holmes, Michael G. Jobling, Duzhang Zhu
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Publication number: 20080311144Abstract: Mutant cholera holotoxins having single or double amino acid substitutions or insertions have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in antigenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.Type: ApplicationFiled: December 19, 2007Publication date: December 18, 2008Applicants: Wyeth Holdings Corporation, The Gov. of the USA, as represented by the Uniformed Services University of Health SciencesInventors: Bruce A. Green, Randall K. Holmes, Michael G. Jobling, Duzhang Zhu
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Patent number: 7384640Abstract: A mutant cholera holotoxin featuring a point mutation at amino acid 29 of the A subunit, wherein the glutamic acid residue is replaced by an amino acid other than aspartic acid, is useful as an adjuvant in an antigenic composition to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus or parasite. In a particular embodiment, the amino acid 29 is histidine. The mutant cholera holotoxin may contain at least one additional mutation in the A subunit at a position other than amino acid 29. The antigenic composition may include a second adjuvant in addition to the mutant cholera holotoxin.Type: GrantFiled: September 30, 1999Date of Patent: June 10, 2008Assignees: Wyeth Holdings Corporation, The United States of America as represented by the Uniformed Services University of the Health SciencesInventors: Randall K. Holmes, Michael G. Jobling, John H. Eldridge, Bruce A. Green, Gerald E. Hancock, Joel A. Peek
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Publication number: 20080091174Abstract: A manually operable pump for the effective removal of fluids to include blood, blood clots, fluid, and air from a body cavity of a subject is provided. The manually operable pump is adapted to be connect to a range of fluid conduits and is equipped with one-way valves that effectively permit flow of fluid through the pump in only one direction. The sensitivity of the one-way valves is such that when properly positioned, fluid can flow through the valves and out of the pump without manual compression of the pump and with the aid of gravity power alone.Type: ApplicationFiled: November 22, 2004Publication date: April 17, 2008Applicants: The Henry M. Jackson Foundation For The Advancement Of Military Medcine, Inc., Uniformed Services University Of The Health SciencesInventors: Hasan B. Alam, Peter Rhee, Emily Rhee
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Patent number: 7332174Abstract: Mutant cholera holotoxins having single or double amino acid substitutions or insertions have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in antigenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.Type: GrantFiled: June 5, 2002Date of Patent: February 19, 2008Assignees: Wyeth Holdings Corporation, The United States of America as represented by the Uniformed Services University of Health SciencesInventors: Bruce A. Green, Randall K. Holmes, Michael G. Jobling, Duzhang Zhu
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Publication number: 20050149993Abstract: The present invention provides a transgenic non-human animals comprising a disruption in the melanopsin gene as well as methods for using the animals to identify agents useful for modulating circadian rhythm in animals.Type: ApplicationFiled: August 8, 2003Publication date: July 7, 2005Applicants: IRM LLC, Uniformed Services University of the Health Sciences, The Scripps Research InstituteInventors: Satchidananda Panda, John Hogenesch, Ignacio Provincio, Steve Kay
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Patent number: 6580937Abstract: A method and apparatus are disclosed for creating peripheral MR angiographic images and performing an MRA examination using an intravascular contrast agent in which MR data acquisition is optimized in the most distal stations in a multi-station acquisition. The technique includes administering a contrast agent into the blood stream of the patient, acquiring low spatial resolution MR images of the arterial vasculature, and tracking the passage of the contrast agent through the patient. The patient table is moved in response to the tracking. The technique continues to acquire low spatial resolution images at each of the proximal stations until the most distal station is reached where a high spatial resolution image data set is then acquired of preferentially arterial vascular structures. Higher spatial resolution images are then acquired in the proximal stations.Type: GrantFiled: December 30, 2000Date of Patent: June 17, 2003Assignees: GE Medical Systems Global Technology Co., LLC, Uniformed Services University of Health Sciences, Department of Defense, United States GovernmentInventors: Vincent B. Ho, Thomas K. F. Foo
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Patent number: 6493569Abstract: A system and method are disclosed that use the steady-state free precessing (SSFP) technique for MR imaging to allow the acquisition of MR angiography images in which the acquisition is not time dependent upon the first passage of a contrast agent. The technique includes applying a pulse sequence with refocusing S− signals from a train of RF pulses to a desired field-of-view (FOV) in a patient in which a contrast bolus has been injected. An SSFP image of the desired FOV is acquired, together with an S− SSFP mask image of the desired FOV. The S− SSFP mask image is subtracted from the SSFP image in order to reconstruct an image with improved visualization of the arterial and venous structures and reduce mis-registration artifacts.Type: GrantFiled: December 30, 2000Date of Patent: December 10, 2002Assignees: GE Medical Systems Global Technology Company, LLC, Uniformed Services University of Health SciencesInventors: Thomas K. F. Foo, Vincent B. Ho
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Patent number: 6408201Abstract: A method and apparatus is disclosed to initially screen a patient's peripheral arterial vasculature for lesions, or stenotic vessels, using MR technology, and then grading the severity of any located stenosis. The invention includes tracking the passage of a contrast agent bolus through a patient, while acquiring a series of first MR images having low resolution. This initial examination uses flow sensitive bi-polar gradient waveforms with a gradient echo imaging pulse sequence to increase the sensitivity to lesion detectability. The bi-polar gradients generate a broad distribution of velocities in a large voxel. Relevant stenoses present in a voxel will result in intra-voxel flow dephasing in voxels immediate to and distal to the stenosis. After identifying a stenosis, a second MR image, having a higher resolution than the first, is used to grade the stenosis.Type: GrantFiled: June 9, 2000Date of Patent: June 18, 2002Assignees: General Electric Company, Uniformed Services University of Health Sciences, Department of Defense, United States GovernmentInventors: Thomas K. F. Foo, Vincent B. Ho
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Patent number: 6354297Abstract: The destruction of undesired fat cells is achieved by use of a device and method whereby apoptosis inducing factors are delivered to undesired fat cells. Adipose inducing factors, such as UV light, IL-1, TNF and dexamethasone are brought into contact with undesired fat cells through the use of an endoscopic device which facilitates conveyance of such factors to such cells. Repeated delivery of such adipose inducing factors can be achieved by having fiberoptic fibers and/or conveyance tubes left beneath a patient's skin in contact with undesired fat.Type: GrantFiled: November 2, 1998Date of Patent: March 12, 2002Assignee: The Uniformed Services University of the Health SciencesInventor: Ben Eiseman
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Patent number: 6317620Abstract: A method and apparatus is disclosed to rapidly assess the severity of a stenosis using MR technology. The invention includes identifying a suspected stenotic vessel and applying a phase contrast pulse sequence to the stenotic vessel in which the MR operator is allowed to control the amplitude and direction of the flow encoding gradient. Peak flow velocity is determined in the suspected stenotic vessel by correlating the flow encoding gradient with the onset of flow velocity aliasing. In a preferred embodiment, the invention utilizes a 2D fast gradient echo pulse sequence having flow sensitizing bipolar gradient waveforms. The resulting flow sensitizing gradients are substantially coincident in time, thereby allowing rotation of the resultant flow sensitizing gradient direction. The amplitude of the flow encoding gradient is increased until the observance of flow related aliasing.Type: GrantFiled: May 4, 2000Date of Patent: November 13, 2001Assignees: General Electric Company, Uniformed Services University of Health SciencesInventors: Vincent B. Ho, Thomas K. F. Foo
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Patent number: 6192264Abstract: A system and method for arterial and venous discrimination in MR venography is disclosed. By setting a noise level in the phase image (that is proportional to the velocity encoding value) at a threshold level between that of the arterial signals and the venous signals during the diastole portion of the cardiac cycle and acquiring a phase contrast MR image during the diastole portion, the arterial signals are effectively suppressed and a venous only image can be reconstructed. Post-processing steps are disclosed which can alternatively provide an arterial only image. By separately reconstructing a magnitude image and a phase image map to produce a magnitude image and a phase image, a masking module can create an output displaying venous only or arterial only images based on a user selection. The present invention allows for a complete noninvasive angiography exam to be completed within approximately 30 minutes.Type: GrantFiled: December 28, 1998Date of Patent: February 20, 2001Assignees: General Electric Company, Uniformed Services University of Health SciencesInventors: Thomas K. F. Foo, Vincent B. Ho, Steven D. Wolff