Patents Assigned to Uniformed Services University of the Health Sciences, an Institution of Higher Learning within the Department of Defense.
  • Oligodeoxynucleotide and its use to induce an immune response
    Patent number: 8741869
    Abstract: A substantially pure or isolated oligodeoxynucleotide of at least 10 nucleotides is disclosed, wherein the oligodeoxynucleotide comprised a sequence represented by either formula: 5? N1N2N3T-CpG-WN4N5N6 3? wherein the CpG motif is unmethylated, W is A or T, and N1, N2, N3, N4, N5, and N6 are nucleotides, or the formula: 5? RY-CpG-RY 3? wherein the central CpG motif is unmethylated, R is A or G, and Y is C or T, as well as an oligodeoxynucleotide delivery complex and a pharmacological composition comprising the present inventive oligodeoxynucleotide, and a method of inducing an immune response by administering the present inventive oligodeoxynucleotide to a host. In some embodiments, the oligodeoxynucleotide includes the nucleic acid sequences set forth as SEQ ID NO: 137.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: June 3, 2014
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, Uniformed Services University of the Health Sciences, an institution of higher learning within the Department of Defense
    Inventors: Dennis M. Klinman, Ken J. Ishii, Daniela Verthelyi, James J. Mond
  • Truncated proteins as cancer markers
    Patent number: 8518652
    Abstract: Methods/reagents for detecting and/or treating cancers or potential cancers are disclosed. In one embodiment, methods and reagents for detecting truncated forms of P2X7 protein in cells are described. In one embodiment, methods and reagents for increasing the amount and/or activity of full-length P2X7 in cells are described. In one embodiment, methods and reagents for decreasing the amount and/or activity of truncated P2X7 in cells are described.
    Type: Grant
    Filed: April 28, 2010
    Date of Patent: August 27, 2013
    Assignees: Uniformed Services University of the Health Sciences, an Institution of Higher Learning within the Department of Defense., The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: George Gorodeski, Ying-Hong Feng, Xin Li