Patents Assigned to UNITED STATE ARMY
  • Liposomal drug delivery constructs targeted by lipid-conjugated peptide ligands
    Publication number: 20090220587
    Abstract: A receptor ligand is conjugated to a lipid-soluble moiety, thereby allowing effective delivery of the peptide ligand to a target cell in the form of a liposome complex. The ligand brings the liposome in proximity to the target cell, facilitating the fusion of the liposome with an endosome of the cellular target to release the payload into the cytoplasm. The liposome itself packages drugs or other therapeutics that are delivered to the interior of the cell upon fusion of the liposome.
    Type: Application
    Filed: February 12, 2009
    Publication date: September 3, 2009
    Applicant: UNITED STATE ARMY
    Inventors: Nahum Allon, Ashima Saxena, Carolyn Chambers, Bhupendra P. Doctor