Abstract: A portable filtration system is described. The system may comprise: a mixing portion, comprising: a pump adaptor and a contaminant regulator. The pump adaptor may comprise: an upper plate, a lower plate, and a screen. The screen may axially extend between the upper and lower plates, wherein the upper plate, the lower plate, and the screen define a channel of a mixing chamber. The contaminant regulator may comprise a through-passage coupled to the upper plate, wherein the through-passage is in fluid communication with the mixing chamber.

Abstract: The present invention is related to the development of therapeutics and prophylactics for the treatment and/or prevention of filovirus infection in humans and other mammals. A new class of small molecules is disclosed that inhibits the interaction of naturally processed (i.e., proteolytically cleaved) filovirus glycoprotein (GPCL) with its host receptor Niemann-Pick C1 (NPC1) protein and thus block infection of host cells by filoviruses. Also disclosed are methods of using the small molecule inhibitors in the treatment/prevention of filovirus infection.

Abstract: Provided here are immunoglobulins and compositions containing one or more of said immunoglobulins reactive to a strain of Marburg virus. The immunoglobulins and compositions comprising said immunoglobulins can be used prophylactically to prevent a Marburg virus infection or to treat a patient that has been exposed to a Marburg virus in order to reduce a symptom.

Abstract: The disclosure relates to compositions, assays, methods and kits comprising one or more amino acid sequences of a filovirus protein, or a fragment thereof, which find use in the detection of a filovirus infection and/or the presence of antibodies specific for a filovirus in a biological sample.

Abstract: Disclosed herein are methods for molecularly characterizing cervical cell samples as being negative for intraepithelial lesion or malignancy (NILM), low-grade squamous intraepithelial lesion (LSIL), or high-grade squamous intraepithelial lesion (HSIL).

Abstract: The present invention relates to attenuated, immunogenic West Nile virus chimeras built on a dengue virus backbone for the production of immunogenic, live, attenuated West Nile virus vaccines,

Abstract: A treatment system delivers a breathing gas and frozen stem cells or other biologic particles (FBP) to a bronchus of a lung of a patient in order to treat lung and other conditions. The breathing gas and the FBP are usually delivered through separate lumens. The FBP may be delivered concurrently with other frozen particles, such as frozen saline particles (FSP). The FBP/FSP will remain frozen at all times from preparation to delivery, and will thaw only after they are released into the lung.

Abstract: Disclosed are methods and articles (e.g., gene arrays or antibodies) for determining the progression or regression of liver fibrosis, for the diagnosis of liver disease, and for screening compounds for hepatotoxicity and efficacy against liver fibrosis. Related therapeutic methods also are disclosed.

Abstract: A system and method using a biomathetical model in conjunction with an optimization method for an individuals alertness impairment at a future time based on a known sleep schedule by adjusting the intake of caffeine over that schedule. In a further embodiment, placing constraints on the frequency, the dose amount, and/or total amount consumed over the course of the future schedule. In a further embodiment, optimizing the sleep schedule (prior to or independent of caffeine optimization) to decrease the individuals alertness impairment at the future time(s). In a further embodiment, adjust both the sleep schedule and caffeine intake to decrease the individuals alertness impairment at the future time(s). In at least one embodiment, the system including a mobile based system and/or a networked computer-based system.

Abstract: A band track including a band having an inner surface, an outer surface, a first side face, and a second side face; a plurality of teeth extending from the inner surface and spaced apart circumferentially around the inner surface; a plurality of lugs extending from the outer surface and each spaced a distance apart circumferentially around the outer surface; a plurality of living hinges defined within the band circumferentially between each of the plurality of teeth; and at least one fiber-reinforcement disposed circumferentially within a neutral plane of the plurality of living hinges and a method of making the same.

Abstract: An enclosure for a UAS includes a housing having a base and a plurality of sidewalls coupled to the base, a motive apparatus coupled to the housing, a platform coupled to the motive apparatus, and a plurality of lids pivotably coupled to the sidewalls and the platform. The platform and the plurality of lids move collectively under control of the motive apparatus (e.g., a linear actuator). Driving the motive apparatus in a first direction causes the platform to raise from a stowed position toward a deployed position and causes each of the plurality of lids to pivot from a closed position toward an open position. Conversely, driving the motive apparatus in a second direction opposite the first direction causes the platform to lower from the deployed position toward the stowed position and causes each of the plurality of lids to pivot from the open position toward the closed position.

Abstract: The invention relates to compounds, compositions and methods for activating, reactivating, reversing or preventing the deactivation of cholinesterases, such as acetylcholinesterase and butyrylcholinesterase.

Abstract: A wearable system, such as a footwear system, can employ a generator. The generator can be powered by human movement, such as movement of knee as a person walks or runs. When the knee resets, it can be desirable to have a relatively equal gear ratio to achieve near natural movement. Conversely, it can be desirable to have a high gear ratio when the knee pushes off to achieve high generator rotation to produce a high amount of power. This can be achieved with employment of a wearable planetary gear set configuration In practicing this wearable planetary gear set, torque can be provided from the source (e.g. human ankle joint) when power negative and not at other times during a movement cycle, meaning energy can be harvested from the walking motion without inducing additional burden to the device wearer.

Abstract: A method and a system analyze an individual's physiological data to identify aberrant vital-signs patterns and estimate an infection probability. The identification includes determining a score based on the current vital-sign measurements, and the mean and standard deviation of baseline vital-signs values. In one embodiment, the mean and the standard deviation are selected based on the corresponding baseline time window and activity bin of the current vital-sign measurement. The score is identified as normal when between two thresholds and aberrant outside of those two thresholds.

Abstract: Various embodiments that pertain to device software is described. A decision can be made by a device on if the device should download an update for device software, such as a software patch. When the device decides that it should download the update, the device can download the appropriate update. In one example, the update can be downloaded by way of a patch portal that communicates with a patch database. The device can request the patch for the software and in response the device can be provided access to the patch by way of the patch portal.

Abstract: Devices, methods and techniques are disclosed for providing a multi-layer diode without voids between layers. In one example aspect, a multi-stack diode includes at least two Drift Step Recovery Diodes (DSRDs). Each DSRD comprises a first layer having a first type of dopant, a second layer forming a region with at least ten times lower concentration of dopants compared to the adjacent layers, and a third layer having a second type of dopant that is opposite to the first type of dopant. The first layer of a second DSRD is positioned on top of the third layer of first DSRD. The first layer of the second DSRD and the third layer of the first DSRD are degenerate to form a tunneling diode at an interface of the first DSRD and second DSRD, the tunneling diode demonstrating a linear current-voltage characteristic.

Abstract: A system, method and apparatus is disclosed, comprising a biomathetical model for optimizing cognitive performance in the face of sleep deprivation that integrates novel and nonobvious biomathematical models for quantifying performance impairment for both chronic sleep restriction and total sleep deprivation; the dose-dependent effects of caffeine on human vigilance; and the pheonotypical response of a particular user to caffeine dosing, chronic sleep restriction and total sleep deprivation in user-friendly software application which itself may be part of a networked system.

Abstract: An underbody kit for a vehicle having an outer body shell defining a cavity, at least one explosive device secured to the outer body shell within the cavity, and wherein the underbody kit is constructed and arranged to counteract both a blast event near the vehicle and a penetrator event.

Abstract: Various embodiments that pertain to an enterprise network that employs a block chain portion and a non-block chain portion. For a single transaction, a header of the transaction can be sent over the block chain network and the non-header of the transaction can be sent over the non-block chain network. A hash-based cuckoo filter can be used for communication of the header along the block chain network.

Abstract: A process for preparing a cathode material of the form LiaMn1-x-y-zFexCoyNizO2-dCld is provided. In addition, a LiaMn1-x-y-zFexCoyNizO2-dCld cathode material for electrochemical systems is provided. Furthermore, a lithium or lithium-ion rechargeable electrochemical cell is provided, incorporating the LiaMn1-x-y-zFexCoyNizO2-dCld cathode material in a positive electrode.