Abstract: A system for mitigation of induced acceleration to an occupant of a vehicle seat includes a substantially non-deforming structure having a top side with the vehicle seat mounted thereon and a bottom side forming a first portion of a floor of the vehicle, and at least one deformable bracket mounting the non-deforming structure to a second portion of the floor that is separate from the first portion of the floor. The at least one deformable bracket deforms, and the non-deforming structure extends through the floor when the vehicle is subjected to an upward force that is equal to or greater than a predetermined force that corresponds to an induced upward acceleration.

Abstract: Disclosed are a semiconductor device and method of manufacturing the same comprising a substrate, a mesa region adjacent to the substrate, an electroplated metal layer, for reducing the thermal resistance of the device, surrounding the mesa region, an insulator layer separating a side portion of the mesa region from the electroplated metal layer, a heat sink, a bonding layer adjacent to the heat sink, and a second metal layer in between the substrate and the heat sink, wherein the substrate is adjacent to the bonding layer, and wherein the electroplated metal layer dimensioned and configured to have a thickness of at least half a thickness of the mesa region; and to laterally spread heat away from the mesa region. The mesa region comprises a first cladding layer adjacent to the substrate, an active region adjacent the first cladding layer, and a second cladding layer adjacent to the active region.

Abstract: The invention is a method for detecting squalene in sera.

Abstract: A method and apparatus for simultaneous fracture and fatigue testing of a semiconductor wafer which includes installing an array of cantilever beams on the wafer, wherein each of the cantilever beams includes a proof mass; mounting the wafer on a base; actuating the base at a predetermined rate of motion causing a displacement of the proof mass; and measuring the displacement. The actuating causes the array to oscillate in a direction perpendicular to the wafer, wherein the displacement of the proof mass is generally perpendicular to a plane of the wafer. Alternatively, the actuating causes the array to rotate around a center of the array, wherein the displacement of the proof mass is generally parallel to a plane of the wafer. The displacement is a function of mechanical stress and strain in the cantilever beams, wherein the mechanical stress and strain causes any of fracture and fatigue of the cantilever beams.

Abstract: A SOI-MEMS gyroscope has a three fold symmetrical construction such that is symmetrical in the x direction, the y direction and diagonally. The gyroscope is suspended above a silicon substrate by lateral flexures that are located at the corners of the proof mass and by central flexures that are positioned at the center regions of the proof mass. The proof mass, lateral flexures, and central flexures are formed of a silicon composition with the flexures supporting the proof mass such that the proof mass will not touch the underlying base silicon substrate even when subjected to extreme G forces. Comb finger actuators apply an electrostatic force to the proof mass in the x direction; and, when experiencing an external rotational rate around the z-axis, the Coriolis force acts along the y direction and the resulting deflection is sensed by a pair of comb-finger capacitors connected as a differential capacitive voltage divider.

Abstract: The present invention relates to methods and assays for detecting bacteriophage MS2 in a sample.

Abstract: A dynamic pressure testing or calibration system packaged as a portable unit for characterizing pressure sensors, such as transducers. Embodiments are packaged for carry on the body, are battery-operated, compatible with existing transducer mounts, and quickly learned and easily used by a single operator. The system supplies a pre-specified impulse (pressure pulse) of fluid, preferably a benign gas, such as air, or an inert gas such as helium or nitrogen. In select embodiments, the gas pulse has a fast rise time and its amplitude may be varied over a pre-specified dynamic range. For example, the rise time may emulate that of an impulse created during an explosion by a resultant pressure wave, i.e., less than 100 microseconds. Embodiments also incorporate a data acquisition capability that accurately captures and records both the supplied impulse and the response of the sensor under test.

Abstract: Using CTL epitopes to the Ebola GP, NP, VP24, VP30, VP35 and VP40 virion proteins, a method and composition for use in inducing an immune response which is protective against infection with Ebola virus is described.

Abstract: A recombinant protein encompassing the complete envelope glycoprotein and a portion of the carboxy-terminus of the membrane/premembrane protein of dengue 2 virus was expressed in baculovirus as a protein particle. The recombinant protein particle was purified and found to provide protection against lethal challenge with dengue 2 virus in mice.

Abstract: The present invention relates to methods and assays for detecting bacteriophage MS2 in a sample.

Abstract: The Chemical-agent Access and Neutralization System (CANS) of the present invention is a small, portable, single-use, disposable chemical treatment apparatus that is used to access and treat Chemical Agent Identification Set (CAIS) ampoules, bottles and/or containers that contain vesicant agents, or chemical warfare agents such as mustard or Lewisite. The apparatus and method of use of the present invention provides a resultant treatment residue that remains totally contained in the CANS treatment container and is safe for disposal. The CANS treatment container can be over packed into a Department of Transportation (DOT) certified shipping container, and shipped to permitted hazardous waste management facilities for ultimate disposal.

Abstract: A KE rod warhead for artillery rockets contains a multiplicity of KE rod penetrators housed in trays and packaged into bays or tier packs that are stacked and positioned around a center column of the warhead. The warhead has a skin which is severed upon the rocket entering a target area. The KE rods are situated and housed in such a manner that upon release the rods experience a minimum of pitching or tumbling upon entering the air stream giving the rods an optimal lethality against a designated target. The KE rod artillery rocket contains no explosive munitions, so it can be used without civilian and environmental concerns over unexploded ordnance.

Abstract: A Thermal Luminescent (TL) spectroscopy system and method for remote sensing and detection of surface chemical contamination involves irradiation of a target surface with energy from a near infrared pump beam, and measurement of TL liberated by that surface within a middle infrared (MIR) region. Fundamental molecular vibration modes of target contaminants present are briefly activated after the surface has been driven out of thermal equilibrium. An emissivity contrast between strata and target contaminant develops, peaks, and then subsides during a finite thermal window of detection opportunity in which detection of fingerprint identifiers for target contaminants is most probable. Target contaminant identification employs neural network models trained and tested against known molecular absorption frequencies of target contaminants. The use of a pump beam that radiates energy outside the MIR spectra of received TL reduces possible interference with the very weak MIR signals given off by target contaminants.

Abstract: Sliding-Action Magneto-Mechanical Injector Throttling Device (SLAMMIT) provides on-demand, yet accurate, throttling of the mass flow of the fuel and/or oxidizer into the combustion chamber of a vortex injector. At least two SLAMMIT sub-assemblies comprise the SLAMMIT Device and each sub-assembly is integrated into a manifold and is driven to slide in a given direction by a drive block that is internal to the sub-assembly. The drive block is, in turn, actuated by an electromagnet that is external to the SLAMMIT sub-assembly. As the SLAMMIT sub-assemblies slide, flappers inside the sub-assemblies achieve the effective opening size of the injection orifices anywhere between fully open and fully closed.

Abstract: A machine gun mount is provided for mounting a machine gun in a movable support arm of a helicopter. The mount includes a gun cradle which is detachably connected to the gun and a pintle one end of which is adapted to pivotably mount the pintle, and thus the mount, on the movable support arm. This enables pivoting movement of the gun in a horizontal plane. The pintle is pivotably connected at the opposite end to the cradle so as to permit the cradle, and thus the gun, to be rotated in a vertical plane through 90 degrees between operative and stowed positions. A locking mechanism locks the cradle in the stowed position. A magazine is attached to one side of the cradle while a spent case and link frame and associated catch bag are attached to the opposite side. The magazine includes an inwardly projecting portion disposed below the cradle.

Abstract: Disclosed herein is a pharmacophore model for antimalarial activity and methods of making and using thereof. The pharmacophore comprises two hydrogen bond acceptor (lipid) functions and two hydrophobic (aromatic) functions. The pharmacophore model was made using a test set of tryptanthrin compounds which exhibit antimalarial activity. Also disclosed are tryptanthrin compounds having greater solubility and bioactivity as compared to prior art tryptanthrin compounds and methods of making and using thereof. Also disclosed are methods of treating malaria in a subject.

Abstract: In this application is described a composition, Invaplex, derived from a gram negative bacteria for use in generating an immune response in a subject against one or more heterologous species or strains of gram-negative bacteria.

Abstract: In this application is described the expression and purification of a recombinant Plasmodium falciparum (FVO) MSP-142. The method of the present invention produces a highly purified protein that retains folding and disulfide bridging of the native molecule. The recombinant MSP-142 is useful as a diagnostic reagent, for use in antibody production, and as a vaccine.

Abstract: Included are embodiments of a method for converting a received analog signal into a digital signal. Some embodiments of the method can include receiving an analog signal; periodically dividing the received analog signal into a plurality of discrete signals at a predetermined interval, wherein each of the plurality of divided signals is associated with a voltage; and quantizing the voltage associated with at least one of the plurality of divided signals. Other systems and methods are also provided.

Abstract: The invention relates to derivatives of pyrroloquinazolinediamine, more specifically derivatives of 7-(substituted)-7H-pyrrolo[3,2-F] quinazoline-1,3-diamines that are non-toxic and are also effective in the treatment of malaria, including P. falciparum and P. vivax strains. The derivatives are certain carbamate derivatives, succinimide derivatives, alkylcarboxamides derivatives and acetamide derivative, phthalimides, alkylamines and all other amide and imide derivatives and their 1-hydroxy analogs. The derivatives of the present invention are also soluble in common organic solvents to facilitate the purification in a large scale synthesis of the composition.