Patents Assigned to United States of America as represented by the Department of Health and Human Resources NIH
  • Kinase inhibitors, compositions thereof, and methods of use therewith
    Patent number: 8765802
    Abstract: Provided herein are Compounds having the following structure: wherein A, L, X and ring B are as defined herein, compositions comprising an effective amount of a Compound and methods for treating or preventing cancer, hypoxia, diabetes, stroke, autoimmune disease or a condition treatable or preventable by inhibition of Chk2, the ATM-Chk2 pathway or RSK2 comprising administering an effective amount of a Compound to a patient in need thereof.
    Type: Grant
    Filed: June 9, 2008
    Date of Patent: July 1, 2014
    Assignees: Provid Pharmaceuticals, Inc., United States of America as represented by the Department of Health and Human Resources NIH
    Inventors: Robert Shoemaker, John Cardellina, Michael Currens, Sudhir Kondapaka, Yves Pommier, Andy Jobson, Dominic Scudiero, David Waugh, George Lountos, Guangtao Zhang, Andrew Colasanti, Christopher R. Self, Janet Cicariello Cook