Patents Assigned to United States of America as represented by The Secretary of Health
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Patent number: 7570986Abstract: A computer-assisted method for detecting surface features in a virtual colonoscopy. The method includes providing a three-dimensional construction of a computed tomography colonography surface; creating a path along the teniae coli from the proximal ascending colon to the distal descending colon on the colonography surface; forming an indexed computed tomography colonography surface using the created path; and registering the supine and prone scans of the computed tomography colonography surface using the indexed computed tomography colonography surface. The method also includes navigating the internal surface of the computed tomography colonography using the indexed computed tomography colonography surface.Type: GrantFiled: May 17, 2006Date of Patent: August 4, 2009Assignee: The United States of America as represented by the Secretary of Health and Human ServicesInventors: Hui-Yang Huang, Dave A. Roy, Ronald M. Summers
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Publication number: 20090117116Abstract: Disclosed are immunogenic peptides, related fusion proteins, nucleic acids encoding the peptides or fusion proteins, conjugates, expression vectors, host cells, and antibodies. Also, disclosed are pharmaceutical compositions, vaccines for use in the treatment or prevention of cancer, e.g., alveolar rhabodomyosarcoma, methods of stimulating a T cell to kill a tumor cell, methods of stimulating CD4+ and CD8+ T cells, and methods of treating or preventing cancer are further provided herein.Type: ApplicationFiled: October 24, 2006Publication date: May 7, 2009Applicant: Government of the United States of America, Represented by the Secretary of Health and Human..Inventors: Jay A. Berzofsky, Leon T. Van Den Broeke, Crystal MacKall, Lee J. Helman
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Patent number: 7517849Abstract: ATP-binding cassette (ABC) transporters generally contain a number of transmembrane helices. The present invention provides synthetic peptides derived from these transmembrane helices. The peptides inhibit ABC transporter function, presumably by disrupting the structure of the ABC transporter. Negatively charged residues are added at the extracellular terminus to promote correct orientation of the peptide in the membrane, and residues considered to aid solubility may be added at that terminus to increase solubility. Exemplary ABC transporters that can be inhibited by these peptides include MDR1, MRP1, MRP2 and BCRP. The invention further provides nucleic acids encoding the peptides, expression cassettes comprising the nucleic acids, and host cells expressing the expression cassettes. The invention further provides a simple and inexpensive assay for determining whether a potential chemotherapeutic agent can inhibit the activity of P-gly-coprotein.Type: GrantFiled: November 17, 2000Date of Patent: April 14, 2009Assignee: The United States of America as represented by the Secretary of Health and Human ServicesInventors: Nadya I. Tarasova, Christopher J. Michejda, Michael M. Gottesman, Christine A. Hrycyna
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Publication number: 20090023164Abstract: This invention relates to compositions and methods or the detection of immunodeficiency virus infection, especially immunodeficiency virus-1 (HIV-1) infection. The invention particularly concerns compositions and methods that may be used in HIV vaccine recipients whose sera may contain vaccine-generated anti-HIV-1 antibodies.Type: ApplicationFiled: September 2, 2005Publication date: January 22, 2009Applicant: The United States of America as Represented by the Secretary of Health and Human Services, NIHInventors: Hana Golding, Surender Khurana
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Patent number: 7459315Abstract: A miniaturized assembly is provided whereby a fluid sample can be divided into a plurality of sample portions in retaining wells and the sample fluid can be displaced from open ends of the wells while simultaneously being sealed in the wells. A method of dividing a fluid sample using the assembly is also provided.Type: GrantFiled: April 25, 2002Date of Patent: December 2, 2008Assignees: Cytonix Corporation, The United States of America as represented by the Secretary of Health and Human ServicesInventor: James F Brown
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Patent number: 7305109Abstract: An automated microscope and computer system captures a set of images for a capture area in a plurality of focal planes. The images can then be integrated into composite images for browsing to simulate viewing an item, such as a biological sample, under a microscope. A corrective filter can be constructed from the images to avoid an effect called “tiling.” Before capture, variable focal plane error can be avoided by collecting z locations for a set of points in the capture area. During image browsing, entire composite images can be loaded into memory in compressed form. Compressed image portions can be pre-decompressed to avoid delay as a browsing user navigates throughout the composite images. Pre-decompression can be done by a thread separate from the thread performing navigation operations.Type: GrantFiled: February 1, 2006Date of Patent: December 4, 2007Assignee: The Government of the United States of America as represented by the Secretary of Health and Human Services, Centers for Disease Control and PreventionInventors: MariBeth Gagnon, Roger Taylor, James V. Lange, Tommy Lee, Carlyn Collins, Richard Draut, Edward Kujawski
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Publication number: 20070275007Abstract: Carbohydrate antigen-nanoparticle conjugates are disclosed. Methods of making carbohydrate antigen-nanoparticle conjugates are also disclosed. The carbohydrate antigen-nanoparticle conjugates can be used to inhibit metastasis of tumor cells in mammals.Type: ApplicationFiled: October 27, 2004Publication date: November 29, 2007Applicants: The Government of the United States of America, represented by the Secretary of Health and Human S, The Research Foundation of State University of New YorkInventors: Joseph Barchi, Kate Rittenhouse-Olson, Sergei Svarovsky
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Patent number: 7268118Abstract: A composition with a polypeptide including amino acid sequence LKKTET [SEQ ID NO:1] or a conservative variant thereof, the composition further including a carrier for application to a surface of a body.Type: GrantFiled: May 26, 2004Date of Patent: September 11, 2007Assignee: United States of America as represented by The Secretary of HealthInventors: Hynda K. Kleinman, Allan L. Goldstein, Katherine M. Malinda, Gabriel Sosne
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Publication number: 20070161891Abstract: A vibrator coil (10) is applied to the skull (30) by adaptation of a commercially available transcranial Doppler monitoring harness (40) during MR applies mechanical waves in the acoustic waves through the skull to the brain. Utilizing magnetic resonance elastography (MRE), non-invasive estimation of tissue elastic properties in three dimensions occurs. The propagation of the acoustic waves through brain tissue, coupled to phase alteration of voxel isochromats in the presence of applies motion encoding magnetic field gradients allows measurements of brain elasticity.Type: ApplicationFiled: March 25, 2004Publication date: July 12, 2007Applicant: The Government of the United States of America, as represented by The Secretary of Health and HumanInventors: David Moore, Seth Goldstein, Randall Pursley, Lalith Talagala
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Patent number: 7175830Abstract: The use of radio-labeled antitumor drugs in the treatment of solid tumors by the method of administering a radio-labeled anticancer drug to a patient and imaging at least a part of the patient using Positron Emission Tomography imaging is described. The method can be used to monitor delivery of antitumor drugs to tumors, to predict the effectiveness of therapy with a particular antitumor drug or combination of antitumor drugs, to assess the effectiveness of modulators of cellular accumulation, to individualize therapy and to evaluate the effectiveness of antitumor drugs with respect to particular cancers. Particularly preferred drugs are labeled taxanes, e.g., 11C-paclitaxel and 11C-docetaxel, labeled anthracyclines, e.g., 11C-doxorubicin and 11C-epirubicin, and other radiolabeled drugs, e.g. 11C-topotecan, 11C-SN-38, and 11C-imatinib. The invention further describes antitumor drugs labeled with the radioactive label 11C and methods of preparing radio-labeled drugs.Type: GrantFiled: December 16, 2002Date of Patent: February 13, 2007Assignee: The United States of America as represented by the Secretary of Health and Human ServicesInventors: Jerry M. Collins, Raymond W. Klecker, Jr., Lawrence W. Anderson
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Publication number: 20070015698Abstract: Compositions and methods for treatment of skin utilizing thymosin ?4.Type: ApplicationFiled: November 22, 2005Publication date: January 18, 2007Applicants: United States of America as represented by The Secretary of Health, Regenerx Biopharmaceuticals, Inc.Inventors: Hynda Kleinman, Allan Goldstein, Katherine Malinda, Gabriel Sosne
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Publication number: 20070009469Abstract: Compositions and methods for treatment of skin utilizing thymosin ?4.Type: ApplicationFiled: November 22, 2005Publication date: January 11, 2007Applicant: United States of America as represented by The Secretary of Health Office of Technology TransferInventors: Hynda Kleinman, Allan Goldstein, Katherine Malinda, Gabriel Sosne
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Patent number: 7001600Abstract: The infusion of TIL586 along with interleukin-2 (IL-2) into the autologous patient with metastatic melanoma resulted in the objective regression of tumor. A gene encoding a tumor antigen recognized by TIL586 was previously isolated and shown to encode gp75 or TRP-1. The present invention relates to the identification of a second tumor antigen recognized by a HLA-A31 restricted CTL clone derived from the TIL586 cell line. This antigen derived from the TRP-2 protein tumor antigen and peptides thereof are capable of sensitizing target cells for lysis by a CTL clone at 1 nM peptide concentration. Modified peptides were also recognized by the CTL clone.Type: GrantFiled: August 30, 2000Date of Patent: February 21, 2006Assignee: The United States of America as represented by the Secretary of Health and Human ServicesInventors: Rong Fu Wang, Steven A. Rosenberg
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Patent number: 6897022Abstract: Chromosomal regions comprising loci associated with susceptibility and resistance to bipolar affective disorder have been identified. Methods and compositions are provided for determining the contribution of these chromosomal regions to bipolar affective disorder in an affected family, for determining in an affected family a genotype associated with increased or decreased susceptibility or resistance to bipolar illness, and for assessing an increased or decreased risk of developing bipolar illness for a tested individual from an affected family.Type: GrantFiled: June 13, 2001Date of Patent: May 24, 2005Assignees: University of Miami, The United States of America as represented by the Secretary of Health & Human ServicesInventors: Edward I. Ginns, Janice A. Egeland, Steven M. Paul
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Publication number: 20040220111Abstract: A composition with a polypeptide including amino acid sequence LKKTET or a conservative variant thereof, the composition further including a carrier for application to a surface of a body.Type: ApplicationFiled: May 26, 2004Publication date: November 4, 2004Applicant: United States of America as Represented by The Secretary of HealthInventors: Hynda K. Kleinman, Allan L. Goldstein, Ketherine M. Malinda, Gabriel Sosne
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Patent number: 6808931Abstract: A method for the determination of hexavalent chromium (CrVI) in environmental and industrial hygiene samples is provided. Based on the chemical properties of chromium species in aqueous solutions, a simple, fast, sensitive, and economical field method has been developed and evaluated for the determination of hexavalent chromium (CrVI). Using ultrasonic extraction in combination with a strong anion exchange solid phase extraction (SAE-SPE) technique, the filtration, preconcentration, and isolation of CrVI in the presence of other chromium species and interferents was achieved.Type: GrantFiled: October 10, 2000Date of Patent: October 26, 2004Assignee: The United States of America as represented by the Secretary of Health and Human ServicesInventors: Jin Wang, Kevin Ashley
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Patent number: 6774141Abstract: The present invention provides novel antiviral compounds, refered to as calanolides, related compounds, and their derivatives, which may be isolated from plants, or derived from compounds from plants, of the genus Calophyllum in accordance with the present inventive method. The compounds and their derivatives may be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the growth or replication of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2.Type: GrantFiled: May 20, 1998Date of Patent: August 10, 2004Assignee: The United States of America as represented by the Secretary of Health and Human ServicesInventors: Michael R. Boyd, John H. Cardellina, II, Kirk R. Gustafson, James B. McMahon, Richard W. Fuller, Gordon M. Cragg, Yoel Kashman
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Patent number: 6673830Abstract: The present invention provides novel antiviral compounds, refered to as calanolides, related compounds, and their derivatives, which may be isolated from plants, or derived from compounds from plants, of the genus Calophyllum in accordance with the present inventive method. The compounds and their derivatives may be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the growth or replication of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2.Type: GrantFiled: June 22, 2001Date of Patent: January 6, 2004Assignees: The United States of America as represented by the Secretary of Health and Human Services, The Board of Trustees of the University of IllinoisInventors: Michael R. Boyd, John H. Cardellina, II, Kirk R. Gustafson, James B. McMahon, Richard W. Fuller, Gordon M. Cragg, Yoel Kashman, Doel Soejarto
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Patent number: 6655382Abstract: A spontaneous breathing apparatus and method. The apparatus includes: a source of oxygen containing gas (7); a catheter (5) in flow communication with the source of oxygen containing gas (7) and configured to be introduced into a subject's trachea (1) through a tracheostomy for delivering oxygen containing gas therein; a tracheostomy tube (9) disposed adjacent the catheter (5) and having one end configured to be disposed in the subject's trachea (1); and a pressure actuated threshold valve (32) connected to another end of the tracheostomy tube (9), the valve (32) being configured for venting a gas existing within the subject's trachea (1) at the one end of the tracheostomy tube (9) when the gas exceeds a threshold pressure of the valve (32), the valve (32) thereby being effective for reducing pressure within the subject's trachea 1) when the pressure within the subject's trachea (1) exceeds the threshold pressure.Type: GrantFiled: May 26, 2000Date of Patent: December 2, 2003Assignee: The United States of America as represented by the Secretary of Health and Human ServicesInventor: Theodor Kolobow
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Patent number: 6552053Abstract: The invention provides a method for modulating attentive cognition comprising administering a compound that alters intraneuronal carbonic anhydrase activity thereby affecting establishment of a theta rhythm. The metabolic pathway of the compound preferably involves bicarbonate-mediated GABAergic depolarization. The term “attentive cognition” is meant to encompass memory formation, learning, spatial memory, and attention. The modulating may be stimulating, or the compound may have the multiple effects of inhibiting intraneuronal carbonic anhydrase activity, establishment of a theta rhythm, and memory acquisition. The invention further provides a method of modulating memory and attention comprising switching theta rhythm on and off, the switching comprising potentiating or inhibiting intraneuronal carbonic anhydrase activity.Type: GrantFiled: June 7, 2001Date of Patent: April 22, 2003Assignee: The United States of America as represented by the Secretary of Health and Human ServicesInventors: Miao-Kun Sun, Daniel L. Alkon, Wei-Qin Zhao