Patents Assigned to United States of America Department of Health and Human Services
  • Publication number: 20210322415
    Abstract: Methods comprising repeating cycles of administration of a composition comprising cediranib according to a fixed intermittent dosing regimen comprising administration of an effective amount of the composition comprising cediranib on one or more consecutive days of a cycle followed by one or more consecutive days of rest on which said composition is not administered are disclosed herein, and may be used as monotherapy or may comprise administration of one or more partner drugs or therapies and may be used in combination therapy.
    Type: Application
    Filed: February 14, 2017
    Publication date: October 21, 2021
    Applicants: ASTRAZENECA AB, THE UNITED STATES OF AMERICA, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Simon BARRY, Jane KENDREW, Tony HO, Stephen Robert WEDGE, Susan Percy IVY, Elise KOHN, Jung-Min LEE
  • Patent number: 10981977
    Abstract: The present invention relates to a novel antibody against HERV-K envelope that targets a conserved region not affected by glycosylation or by native conformation, and its use in diagnostics and/or is therapy.
    Type: Grant
    Filed: June 17, 2020
    Date of Patent: April 20, 2021
    Assignees: GENEURO SA, THE UNITED STATES OF AMERICA, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Hervé Perron, Julie Medina, Avindra Nath, Joseph Perry Steiner, Wenxue Li, Myoung-Hwa Lee
  • Patent number: 10335460
    Abstract: Described herein are dose escalation regimens for the administration of complexes comprising interleukin-15 (“IL-15”) covalently or noncovalently bound to IL-15 receptor alpha (“IL-15R?”) to patients in order to enhance IL-15-mediated immune function. In a specific aspect, the dose escalation regimens are useful in the prevention, treatment, and/or management of disorders in which enhancing IL-15-mediated function is beneficial, such as cancer, infectious diseases, immunodeficiencies and lymphopenia. In another specific aspect, the dose escalation regimens are useful for eradicating or reducing HIV in HIV-infected patients.
    Type: Grant
    Filed: July 28, 2015
    Date of Patent: July 2, 2019
    Assignees: NOVARTIS AG, The United States of America Department of Health and Human Services
    Inventors: Barbara K. Felber, Sergio Finkielsztein, George N. Pavlakis, John N. Vournakis
  • Patent number: 10266488
    Abstract: Human lipoxygenases (LOXs) are a family of iron-containing enzymes involved in catalyzing the oxidation of polyunsaturated fatty acids to provide the corresponding bioactive hydroxyeicosatetraenoic acid (HETE) metabolites. These eicosanoid signaling molecules are involved in a number of physiologic responses such as platelet aggregation, inflammation, and cell proliferation. Platelet-type 12-(S)-LOX (12-LOX) is of particular interest because of its demonstrated role in skin diseases, diabetes, platelet hemostasis, thrombosis, and cancer. Disclosed herein is the identification and medicinal chemistry optimization of a 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide-based scaffold. The compounds display nM potency against 12-LOX and excellent selectivity over related lipoxygenases and cyclooxygenases. In addition to possessing favorable ADME properties, the compounds also inhibit PAR-4 induced aggregation and calcium mobilization in human platelets, and reduce 12-HETE in mouse/human beta cells.
    Type: Grant
    Filed: October 10, 2014
    Date of Patent: April 23, 2019
    Assignees: Eastern Virginia Medical School, The Regents of the University of California Santa Cruz, The United States of America Department of Health and Human Services, Thomas Jefferson University
    Inventors: David J. Maloney, Diane K. Luci, Ajit Jadhav, Theodore Holman, Jerry L. Nadler, Michael Holinstat, David Taylor-Fishwick, Anton Simeonov, Adam Yasgar, Steven McKenzie
  • Patent number: 9259452
    Abstract: The present invention relates to deacetylase inhibitor (e.g., histone deacetylase inhibitor) therapies and demonstrates that individuals with low electrolyte levels may have increased susceptibility to certain unwanted side effects such as cardiac side effects. In some embodiments, the invention provides methods of administering DAC or DAC inhibitor therapy that includes electrolyte supplementation.
    Type: Grant
    Filed: January 6, 2015
    Date of Patent: February 16, 2016
    Assignees: Gelgene Corporation, The United States of America Department of Health and Human Services
    Inventors: William McCulloch, Richard L. Piekarz, Susan E. Bates
  • Patent number: 7858928
    Abstract: Embodiments of the invention include methods and devices for the analysis of proteins utilizing a gold coated nanoporous alumina surface for dual ionization mode mass spectrometric analysis using desorption electrospray ionization (DESI) and laser desorption ionization (LDI). Combined use of DESI and LDI gives increased sequence coverage in peptide mixture analysis from a single sample preparation.
    Type: Grant
    Filed: September 20, 2007
    Date of Patent: December 28, 2010
    Assignee: The United States of America Department of Health and Human Services
    Inventor: Daniel R. Knapp
  • Publication number: 20090092557
    Abstract: An isolated and purified nucleic acid molecule that encodes a polypeptide comprising at least eight contiguous amino acids of SEQ ID NO: 3, wherein the at least eight contiguous amino acids have anti-viral activity, as well as an isolated and purified nucleic acid molecule that encodes a polypeptide comprising at least eight contiguous amino acids of SEQ ID NO: 3, wherein the at least eight contiguous amino acids have anti-viral activity, and, when the at least eight contiguous amino acids comprise amino acids 1-121 of SEQ ID NO: 3, the at least eight contiguous amino acids have been rendered glycosylation-resistant, a vector comprising such an isolated and purified nucleic acid molecule, a host cell comprising the nucleic acid molecule, optionally in the form of a vector, a method of producing an anti-viral polypeptide or conjugate thereof, the anti-viral polypeptide itself, a conjugate or fusion protein comprising the anti-viral polypeptide, and compositions comprising an effective amount of the anti-viral
    Type: Application
    Filed: May 27, 2005
    Publication date: April 9, 2009
    Applicant: Government of the United States of America Department of Health and Human Services
    Inventors: Michael R. Boyd, Toshiyuki Mori, Barry R. O'Keefe
  • Publication number: 20090029930
    Abstract: The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.
    Type: Application
    Filed: December 11, 2006
    Publication date: January 29, 2009
    Applicants: Utah, University of, Research Foundation, Johns Hopkins University, Baylor College of Medicine, United States of America Department of Health and Human Services
    Inventors: Rando Allikmets, Kent L. Anderson, Michael Dean, Mark Leppert, Richard A. Lewis, Yixin Li, James R. Lupski, Jeremy Nathans, Amir Rattner, Noah F. Shroyer, Nanda Singh, Philip Smallwood, Hui Sun
  • Patent number: 7402400
    Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: July 22, 2008
    Assignees: Regents of the University of California, The United States of America Department of Health and Human Services
    Inventors: Charles S. Zuker, Nicholas J. P. Ryba, Gregory A. Nelson, Mark A. Hoon, Jayaram Chandrashekar, Yifeng Zhang
  • Patent number: 7250097
    Abstract: An apparatus and method for the sequential electroelution of biomolecules is described, the apparatus comprising a separation medium having an outlet, and a collector having at least a first receptacle and a second receptacle that can be sequentially brought into contact with the outlet of the separation medium by translating the first receptacle and the second receptacle in relation to the outlet of the separation medium, and the method comprising the steps of receiving a first substantially separated molecule in the first receptacle and translating the first receptacle and the second receptacle such that the second receptacle is brought into in contact with the outlet of the separation medium, receiving a second substantially separated molecule in the second receptacle, and repeating said steps to sequentially receive a desired number of substantially separated molecules.
    Type: Grant
    Filed: July 9, 2004
    Date of Patent: July 31, 2007
    Assignee: The United States of America, Department of Health and Human Services
    Inventors: József Antal, Zsuzsanna Buzás, Andreas Chrambach
  • Publication number: 20060057556
    Abstract: Contiguous capillaries useful for separating and electrospraying a fluid comprising analyte and electrolyte are provided. The contiguous capillaries have spray tips at one end of the capillaries and electrically conductive portions in proximity to the spray tips. Methods for making the contiguous capillaries and their use as electrospray sources are also disclosed. Apparatus and methods for conveying analyte ions from the capillaries into analytical instruments, such as a mass spectrometer, are also disclosed. The disclosed contiguous capillaries may be used to carryout electrophoresis separation and electrospray ionization of analytes. Methods for obtaining the mass spectra of macromolecular analytes at concentrations lower than previously possibly are provided using the apparatus and procedures described herein.
    Type: Application
    Filed: October 20, 2003
    Publication date: March 16, 2006
    Applicant: The Government of the United States of America Department of Health and Human Services
    Inventors: George Janini, Haleem Issaq, Timothy Veenstra, Thomas Conrads, Kenneth Wilkens
  • Publication number: 20040204395
    Abstract: The present invention relates to water-soluble drugs, compositions containing same, and, in particular, a water-soluble analogue of geldanamycin. This invention also relates to a method of producing water-soluble analogues of water-insoluble drugs through derivatization and conjugation with a polar moiety via a thiol ether bond with a heterobifunctional linking molecule.
    Type: Application
    Filed: May 3, 2004
    Publication date: October 14, 2004
    Applicant: Government of the United States of America, Department of Health and Human Services
    Inventors: David K. Ho, Raya Mandler, Ada Belinda Alvarado-Lindner, Kaye B. Dillah Upadhyay, David J. Newman
  • Publication number: 20030148506
    Abstract: A method of producing an adeno-associated virus (AAV) in an insect cell comprising (i) providing at least one insect cell-compatible vector comprising a first nucleotide sequence comprising at least one AAV ITR nucleotide sequence, a second nucleotide sequence containing an open reading frame encoding AAV VP1, VP2, and VP3 capsid proteins, a third nucleotide sequence comprising a Rep52 or a Rep40 coding sequence, and a fourth nucleotide sequence comprising a Rep78 or a Rep68 coding sequence, (ii) introducing the at least one insect cell-compatible vector into an insect cell, and (iii) maintaining the insect cell under conditions such that AAV is produced. Also provided are recombinant AAV made in accordance with the method, insect cell-compatible vectors, and insect cells comprising nucleotide sequences for production of AAV in an insect cell.
    Type: Application
    Filed: August 13, 2002
    Publication date: August 7, 2003
    Applicant: The Government of the United States of America, Department of Health and Human Services
    Inventors: Robert M. Kotin, Masashi Urabe, Chuan-Tian Ding
  • Publication number: 20030059771
    Abstract: The present invention relates to Ras-family proteins and tumor suppressor genes. Specifically, the present invention provides the Ras-related tumor suppressor gene and protein Rig, as well as means for the regulation of cell growth.
    Type: Application
    Filed: June 4, 2001
    Publication date: March 27, 2003
    Applicant: THE UNITED STATES OF AMERICA, Department of Health and Human Services
    Inventors: Geoff J. Clark, Chad A. Ellis, Michelle Vos
  • Publication number: 20020151886
    Abstract: Disclosed are methods and devices for occluding the lumen of a hollow organ by delivering radiofrequency energy to the inner wall of a hollow organ. The disclosure includes radiofrequency electrodes that expand, in a deployed condition, to contact the walls of the organ. In some embodiments, the electrodes substantially conform to the inner wall to enhance therapeutic contact. Methods are also disclosed for using these electrodes to totally or partially occlude a lumen, or remove or reduce a total or partial occlusion of a lumen.
    Type: Application
    Filed: December 6, 2001
    Publication date: October 17, 2002
    Applicant: The Government of the United States of America, Department of the Health and Human Services
    Inventor: Bradford J. Wood
  • Publication number: 20020123049
    Abstract: A recombinant plasmid and an RNA sequence expressed by said plasmid are described. The RNA sequence hybridize specifically with human c-fes mRNA.
    Type: Application
    Filed: May 15, 2001
    Publication date: September 5, 2002
    Applicant: The United States of America, Department of Health and Human Services
    Inventors: Robert I. Glazer, Thomas E. Smithgall, Gang Yu
  • Publication number: 20020077308
    Abstract: The present invention provides a method of treating or preventing the inflammatory response of an inflammatory bowel disease in a subject, comprising administering to the subject an amount of a STAT-4 antisense oligonucleotide effective in treating or preventing the inflammatory response of the inflammatory bowel disease.
    Type: Application
    Filed: March 19, 2001
    Publication date: June 20, 2002
    Applicant: The Government of The United States of America, Department of Health and Human Services
    Inventors: Warren Strober, Ivan Fuss, Markus Neurath, Atsushi Kitani
  • Publication number: 20020013299
    Abstract: The present invention provides AGT inactivating compounds such as substituted O6-benzylguanines of the formula 1
    Type: Application
    Filed: August 14, 2001
    Publication date: January 31, 2002
    Applicant: The Government of the United States of America, Department of Health and Human Services
    Inventors: Robert C. Moschel, Anthony E. Pegg, M. Eileen Dolan, Mi-Young Chae
  • Publication number: 20020002144
    Abstract: The present invention provides a method of producing a bisubstrate inhibitor in a cell, comprising introducing into the cell an alkylating derivative of an acetyl acceptor substrate for an acetyltransferase present in the cell. Further provided is a method of inhibiting the activity of an acetyltransferase in a cell, comprising introducing into the cell an alkylating derivative of an acetyl acceptor substrate for an acetyltransferase present in the cell under conditions whereby a bisubstrate inhibitor will be produced, thereby inhibiting the activity of the acetyltransferase in the cell.
    Type: Application
    Filed: July 20, 2001
    Publication date: January 3, 2002
    Applicant: The Government of the United States of America, Department of Health & Human Services
    Inventors: David C. Klein, M. A.A. Namboodiri, Joan L. Weller, Jeffrey A. Kowalak, Anthony K. Ho
  • Publication number: 20010053958
    Abstract: The present invention is directed to an improved method for detecting a genetic marker in a biological sample comprising contacting the biological sample with a nucleic acid probe linked to a detectable moiety, whereby the detectable moiety can be detected by the presence of a chromogenic dye associated with the detectable moiety, obtaining a spectral image of the biological sample using brightfield microscopy, and detecting the presence of the chromogenic dye, thereby detecting the genetic marker in the biological sample.
    Type: Application
    Filed: June 29, 2001
    Publication date: December 20, 2001
    Applicant: The Govenment of the United States of America, Department of Health & Human Services
    Inventors: Thomas Ried, Merryn V.E. Macville, Anton H.N. Hopman