Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.
Type:
Grant
Filed:
August 20, 2003
Date of Patent:
March 24, 2009
Assignees:
The Regents of the University of California, United States of America Dept. of Health and Human Services National Institutes of Health-OTT
Inventors:
Charles S. Zuker, Nicholas J. P. Ryba, Gregory A. Nelson, Mark A. Hoon, Jayaram Chandrashekar, Yifeng Zhang