Abstract: Several mutated strains of Scheffersomyces stipitis are generated by repetitive culturing of the parent strain on two types of concentrated hydrolyzates and with ethanol-challenged xylose-fed continuous culture. Isolates collected from various enriched populations are screened and ranked based on relative xylose uptake rate and ethanol yield. Ranking on hydrolyzates with and without nutritional supplementation is used to identify those isolates with best performance across diverse conditions.

Abstract: A method to remove epitaxial semiconductor layers from a substrate by growing an epitaxial sacrificial layer on the substrate where the sacrificial layer is a transition metal nitride (TMN) or a TMN ternary compound, growing one or more epitaxial device layers on the sacrificial layer, and separating the device layers from the substrate by etching the sacrificial layer to completely remove the sacrificial layer without damaging or consuming the substrate or any device layer. Also disclosed are the related semiconductor materials made by this method.

Abstract: Systems and methods for controlling lab equipment such as transmitters are provided that includes a mini automation controller (MAC). The system provides a control system, user interface, and interfaces, including network interfaces usable for interfacing equipment, MAC, and user interfaces over a network, which provide a variety of functions including automation and monitoring of transmission sequences and receiver events. An exemplary MAC may include an Ethernet controller capable of converting an Ethernet signal to a serial signal. The MAC may also include a receiver monitor section comprising a fiber optic receiver input, a copper cable receiver input, and a monostable multivibrator. In addition to the receiver monitor section, the MAC may have a transmitter control section including a transmitter control pulse and a power output. An exemplary MAC may have a microcontroller coupled to the Ethernet controller, the receiver monitor section, and the transmitter control section.

Abstract: A pistol grip suction device comprises a hollow body member having first leg joining second leg at elbow, the legs being generally tubular and disposed approximately 90 degrees apart; a push rod extending through push rod aperture at elbow, the push rod extending into hollow second leg, the push rod having a button on proximal end outside the body, and valve on distal end inside the body; a valve seat disposed within second leg around push rod; valve mounted on the push rod through the valve seat, the suction port having a diameter at least two times the diameter of push rod through suction port; a spring biasing push rod into extended position with respect to second leg such that valve bears against valve seat and closes suction port, wherein a force against button greater than biasing force of spring displaces valve from valve seat and opens suction port.

Abstract: The present disclosure relates to certain amine derivatives of fused bicyclic heterocycles that inhibit the amine reuptake function of the biogenic amine transporters, dopamine transporter (DAT), serotonin transporter (SERT) and norepinephrine transporter (NET). Compounds of the present disclosure are potent inhibitors of the reuptake of dopamine (DA), serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE) with full or partial maximal efficacy. The compounds with partial maximal efficacy in inhibiting reuptake of all three biogenic amines are herein referred to as partial triple uptake inhibitors (PTRIs). Compounds of the present disclosure are useful for treating depression, pain and substance abuse and relapse to substance abuse and addiction to substances such as cocaine, methamphetamine, nicotine and alcohol. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors, cells, fusion proteins, constructs, conjugates, and methods of inhibiting viral infection.

Abstract: The invention provides methods of treating or preventing malaria comprising administering to an animal an effective amount of a compound of formula I: Q—Y—R1—R2??(I), wherein Q, Y, R1, and R2 are as described herein. Methods of inhibiting a plasmodial surface anion channel of a parasite in an animal are also provided. The invention also provides pharmaceutical compositions comprising a compound represented by formula I in combination with any one or more compounds represented by formulas II, V, and VI. Use of the pharmaceutical compositions for treating or preventing malaria or for inhibiting a plasmodial surface anion channel in animals including humans are also provided. Also provided by the invention are clag3 amino acid sequences and related nucleic acids, vectors, host cells, populations of cells, antibodies, and pharmaceutical compositions.

Abstract: An infrasonic stethoscope for monitoring physiological processes of a patient includes a microphone capable of detecting acoustic signals in the audible frequency bandwidth and in the infrasonic bandwidth (0.03 to 1000 Hertz), a body coupler attached to the body at a first opening in the microphone, a flexible tube attached to the body at a second opening in the microphone, and an earpiece attached to the flexible tube. The body coupler is capable of engagement with a patient to transmit sounds from the person, to the microphone and then to the earpiece.

Abstract: Embodiments of the invention disclose methods of assembling and using an adjustable inductor to vary inductance. An adjustable inductor, according to embodiments of the invention, includes a wire coil configured to mount on a first side of a conductive plate. The wire coil is conductive and is a plurality of windings. A core has a first portion and a second portion. The first and second portions are configured with a plurality of grooves for threading engagement with the plurality of windings of the wire coil. The threading engagement attaches the core to the plurality of windings of the wire coil. Rotating the core results in varied inductance.

Abstract: A novel, mutated Salmonella enterica serovar Typhimurium vaccine is generated and imparts protective immunity in vaccinated animals for a range of S. enterica serovars. The vaccine can be attenuated or inactivated, including bacterial ghosts or membrane fractions thereof. Immunogenic compositions are included in the invention and methods of generating an immune response.

Abstract: A capacitor having first and second electrodes and a scaffold dielectric. The scaffold dielectric comprises an insulating material with a plurality of longitudinal channels extending across the dielectric and filled with a liquid comprising cations and anions. The plurality of longitudinal channels are substantially parallel and the liquid within the longitudinal channels generally has an ionic strength of at least 0.1. Capacitance results from the migrations of positive and negative ions in the confined liquid in response to an applied electric field. A method of supplying power to a load using the capacitor and a method of making the capacitor is additionally disclosed.

Abstract: A testing apparatus to assess ballistic performance of helmet personnel protective equipment having a flat helmet analog with a helmet shell material in flat panel form and at least one helmet suspension pad; head surrogate components including a skull skin surrogate, a skull bone surrogate, and a brain tissue surrogate; a pressure indicating film adjacent to the head surrogate components; and one or more pressure sensors in the brain tissue surrogate. Also disclosed is the related method for assessing ballistic performance of helmet personnel protective equipment.

Abstract: Methods of inhibiting metastasis in cancer patients are provided, wherein the methods comprise reducing TGF? signaling, for example, by reducing TGF? receptor II expression in myeloid cells. Vectors comprising a TGF? receptor II RNAi nucleic acid sequence operably linked to a myeloid specific promoter also are provided. A method of diagnosing cancer in an individual by determining TGF? receptor II expression in myeloid cells in the individual is provided. Additionally, a method of modulating TGF? activity in myeloid cells in a cancer patient comprising administering a regulator of at least one of the GSK3 and PI3K pathways to the patient is provided.

Abstract: Various embodiments associated with a composite image are described. In one embodiment, a handheld device comprises a launch component configured to cause a launch of a projectile. The projectile is configured to capture a plurality of images. Individual images of the plurality of images are of different segments of an area. The system also comprises an image stitch component configured to stitch the plurality of images into a composite image. The composite image is of a higher resolution than a resolution of individual images of the plurality of images.

Abstract: Herein is described a novel hybridoma cell line (RMH359) and its use as a cellular bioassay to determine the efficacy of cell conditioned media (CCM) as a supplement used to support cell survival and promote growth in culture. This bioassay is the first to provide a measure of CCM bioactivity in support of hybridoma cells used in the generation and production of monoclonal antibodies.

Abstract: In various aspects, methods and apparatuses for liquid-liquid extraction are provided. In certain aspects, an emulsion can be formed by combining a feed stream, an extractant, and a surfactant. The feed stream comprises a plurality of distinct components including a first component to be removed therefrom. The feed stream may be selected from a group consisting of: a hydrocarbon feed stream and an azeotrope. Then, a portion of the first component is extracted from the feed stream (or emulsion) by contact with a superoleophobic and hygroscopic membrane filter that facilitates passage of the first component and extractant through the superoleophobic and hygroscopic membrane filter. A purified product is collected having the portion of the first component removed. Such methods are particularly useful for refining fuels and oils and separating azeotropes and other miscible component systems. Energy-efficient, continuous single unit operation apparatuses for conducting such separation techniques are also provided.

Abstract: Provided are materials and processes for removing nitrogen dioxide gas from a sample by contacting the sample with a filtration media that includes a MOF, optionally an amine containing MOF. The resulting filtration media has the ability to sequester nitrogen dioxide with little conversion to nitric oxide, is stable, and highly functional so as to be useful in protective equipment or other filtration systems.

Abstract: An adjustable inductor, according to embodiments of the invention, includes a wire coil configured to mount on a first side of a conductive plate. The wire coil is conductive and is a plurality of windings. A core has a first portion and a second portion. The first and second portions are configured with a plurality of grooves for threading engagement with the plurality of windings of the wire coil. The threading engagement attaches the core to the plurality of windings of the wire coil, which results in varied inductance.

Abstract: IR emission devices comprising an array of polaritonic IR emitters arranged on a substrate, where the emitters are coupled to a heater configured to provide heat to one or more of the emitters. When the emitters are heated, they produce an infrared emission that can be polarized and whose spectral emission range, emission wavelength, and/or emission linewidth can be tuned by the polaritonic material used to form the elements of the array and/or by the size and/or shape of the emitters. The IR emission can be modulated by the induction of a strain into a ferroelectric, a change in the crystalline phase of a phase change material and/or by quickly applying and dissipating heat applied to the polaritonic nanostructure. The IR emission can be designed to be hidden in the thermal background so that it can be observed only under the appropriate filtering and/or demodulation conditions.

Abstract: The disclosure provides pharmaceutical preparations containing (2R,6R)-hydroxynorketamine, or (R)- or (S)-dehydronorketamine, or other stereoisomeric dehydro or hydroxylated ketamine metabolite. (2R,6R)-hydroxynorketamine The disclosure also provides novel ketamine metabolite prodrugs. The disclosure provides methods of treating, bipolar depression, major depressive disorder, neuropathic and chronic pain, including complex regional pain synthetic pain disorder (CRPD) by administering a purified ketamine metabolite or a ketamine metabolite prodrug directly to patients in need of such treatment.