Abstract: A driver apparatus is provided for use with a biopsy instrument, the driver apparatus including a housing and an insertion mechanism including a carriage movably associated with the housing and adapted to support the biopsy instrument to affect longitudinal movement of at least a portion of the biopsy instrument. A linear motion control mechanism is also included that is adapted to move a tissue cutting element of the biopsy instrument from a first position to a second position relative to a tissue receiving portion of the biopsy instrument. Further, a tissue retract mechanism is included which facilitates removal of a tissue specimen from the biopsy instrument without removing the entire biopsy instrument from a surgical site.

Abstract: Apparatus and method for surgery is disclosed which includes a retractor having a substantially planar base defining an opening for overlying an operative site on a patient, and at least one retractor blade slidably mounted to the base. The base is positioned on the patient such that the opening therein overlies the operative site. The operative site is percutaneously accessed, and obstructing tissue is retracted by engaging the tissue with the retractor blade. A surgical instrument is provided which is engageable with the base and operable at the operative site through the opening in the base. A surgical procedure is carried out through the opening in the base with the surgical instrument.

Abstract: Fibrin sealant applicator systems are provided for dispensing a first and a second protein solution to form a biological adhesive which overcome the disadvantages of the prior art. The first and second protein solutions are preferably fibrinogen and thrombin solutions which may intermix on an application site or within the applicator to form a fibrin sealant. The fibrin sealant applicator systems according to the present disclosure include two piston-type sub-assemblies coupled to two vials storing the fibrinogen and thrombin via a coupling unit. The piston-type sub-assemblies store sterilized water within reservoirs which are in fluid communication with the vials via the coupling unit. The water is forced into the vials to form the fibrinogen and thrombin solutions.

Abstract: A radiation detection apparatus includes a scintillation counter, a download control device for outputting a scintillation count to a utilization device, and a hand-held probe including a scintillation detector. The apparatus also includes a connector for connecting the probe to the counter, and a switch assembly removably mounted to the probe. The switch assembly has a first trigger for causing the counter to accumulate a first scintillation count over a first period, the counter to accumulate a second scintillation count over a second period, and the detection apparatus to display the second scintillation count. The switch assembly has a second trigger for causing, upon activation, the download control device to manifest an accumulated scintillation count from the counter. A lack of activation of the second trigger during the display of the second scintillation count causes the counter to resume accumulating scintillation counts over the first period.

Abstract: An applicator is provided for dispensing a first and a second protein solution to form a biological adhesive where the solutions can be deflected by a deflection assembly during dispensing for the adhesive to cover a broad or limited area. The applicator includes a housing having a housing head for enclosing therein a first reservoir containing a first component, and a second reservoir containing a second component. The first and second components are preferably fibrinogen and thrombin which intermix with water to form the first and second protein solutions, respectively. The housing further includes an elongated body portion defining a longitudinal axis for enclosing therein a conduit assembly having a first and a second conduit in communication with the first and second reservoir, respectively. The solutions intermix on an application site to form a fibrin sealant. In an alternate embodiment, the applicator includes two valves.

Abstract: An apparatus for thermal treatment of tissue, includes an outer member having a frame dimensioned for engagement with the hand of a surgeon and an elongated portion connected to the frame and extending distally therefrom. The elongated portion defines a longitudinal axis and has an axial opening. An electromagnetic probe assembly is releasably mounted to the outer member. The electromagnetic probe assembly includes a handle and an electromagnetic probe connected to the handle. The electromagnetic probe is at least partially positionable within the axial opening of the elongated portion and is adapted for reciprocal longitudinal movement therewithin between a non-deployed position and a deployed positions. A manually operable release member releasably mounts the electromagnetic probe assembly to the outer member.

Abstract: A surgical training apparatus and method are provided simulating a patient having background radiation emissions level and at least one concentrated source of radiation emissions. The apparatus includes a plurality of notches in a lower base portion for receiving test sources, and a cover for overlaying the lower base during the training procedures. Identification indicia is provided within each of the notches and on the cover to correlate the notch position with the closed cover surface. A radiation detection device is used to scan the surfaces in training surgeons for radiation identification and localization techniques.

Abstract: A method of reducing scar formation at a wound site includes contacting the wound site with an effective scar reducing amount of a cross-linked polysaccharide having a positive charge and thereby reducing scar formation as the wound site heals. Such polysaccharide include bioabsorbable cross-linked dextrans or alginates. The positive charge may be provided by diethylaminoethyl (DEAE) moieties. The cross-linked polysaccharide can be applied to the wound site as a powder or bead. The cross-linked polysaccharide may also be contained in a composition including a pharmaceutically acceptable vehicle. Biocompatable surgical devices are provided with an effective scar reducing amount of a cross-linked polysaccharide having a positive charge which reduce scar formation at healing wound sites. A method of reducing TGF-&bgr; activity is also provided.

Abstract: A safety trocar is provided in which the cannula is reciprocally mounted to the cannula housing and reciprocates into the cannula housing when a proximally directed force is applied thereto. The piercing tip is maintained in the exposed position by a latching mechanism associated with the obturator shaft, and is automatically withdrawn into the cannula under the force of a spring when the proximal force is removed from the cannula, the cannula thus advancing distally and releasing the latching mechanism. Penetration force is maintained at a minimum, and safe and efficacious trocar entry is facilitated.

Abstract: A synthetic absorbable monofilament comprising glycolide and epsilon caprolactone is provided. The monofilament exhibits physical characteristics equivalent to or superior than gut sutures. The monofilaments can be fabricated into a wide variety of surgical devices such as sutures, meshes, and the like.

Abstract: Incorporation of certain amino acid analogs into polypeptides produced by cells which do not ordinarily provide polypeptides containing such amino acid analogs is accomplished by subjecting the cells to growth media containing such amino acid analogs. The degree of incorporation can be regulated by adjusting the concentration of amino acid analogs in the media and/or by adjusting osmolality of the media. Such incorporation allows the chemical and physical characteristics of polypeptides to be altered and studied. In addition, nucleic acid and corresponding proteins including a domain from a physiologically active peptide and a domain from an extracellular matrix protein which is capable of providing a self-aggregate are provided. Human extracellular matrix proteins capable of providing a self-aggregate collagen are provided which are produced by prokaryotic cells. Preferred codon usage is employed to produce extracellular matrix proteins in prokaryotics.

Abstract: An apparatus and method for the biopsy of tissue specimens and, more particularly, a single insertion multiple sample percutaneous biopsy apparatus and method are provided. A tip at a distal end of a vacuum support tube is introduced into a tissue mass. The vacuum support tube is retracted exposing a basket tube bounded by a front washer and a rear washer mounted thereabout forming a tissue basket. The basket tube is supported internally by a thrust tube which provides structure to the apparatus to allow it to penetrate tissue. The thrust tube and the basket tube are in fluid connection and are provided with suction to draw tissue inward. The tissue is then severed by rotating and advancing a knife edge at the distal end of the vacuum support tube. The tissue basket is withdrawn and the tissue sample is removed by rotating the vacuum support tube. The tissue sample is sliced longitudinally, and a stripper scrapes the tissue sample from an opening in the vacuum support tube.

Abstract: A surgical instrument is provided for use in endoscopic or laparoscopic procedures. The instrument includes a handle portion, an endoscopic portion extending from the handle portion, an articulating section pivotably connected to a distal end portion of the endoscopic portion, and a retractor assembly operatively associated with the articulating section. Structure is provided for manipulating the articulating section relative to the longitudinal axis of the endoscopic portion within an angular degree of rotation. An injection port may also be provided to deliver fluids through the endoscopic portion to the operative site.

Abstract: An ultrasonic dissection and coagulation system for surgical use is provided. The system includes an ultrasonic instrument, a control module, and a remote actuator. The ultrasonic instrument has a housing and an elongated body portion extending from the housing. An ultrasonic transducer supported within the housing is operatively connected to a cutting jaw by a vibration coupler. The vibration coupler conducts high frequency vibration from the ultrasonic transducer to the cutting jaw. The cutting jaw has a blade surface which is curved downwardly and outwardly in the distal direction with respect to the longitudinal axis of the elongated body portion along its length such that an angle defined by a line drawn tangent to the blade surface and the longitudinal axis of the elongated body portion varies between 5 degrees and 75 degrees.

Abstract: Apparatus and methods for applying fasteners during endoscopic surgery. The apparatus generally comprises a handle portion, a triggering mechanism and a fastener applicator. In one embodiment, the invention forms the fastener around a pair of anvils. Another embodiment uses a two section ramp to move the fasteners from a fastener storage channel to a position at least partially in a fastener driving channel. The various embodiments may be variously combined together in a single device.

Abstract: A surgical stapling apparatus having first and second handle members pivotably mounted to one another for movement from an open position to a closed position to clamp body tissue between the distal jaws. After the body tissue is clamped, a trigger mechanism is activated to advance a staple pusher to force a staple through the tissue and into contact with an anvil to deform the staple legs. An actuating lever may be interposed between the trigger mechanism and the staple pusher.

Abstract: A surgical instrument for performing an anastomosis includes a housing having a proximal end and a distal end; a shaft extending from the housing distal end; and a disposable loading unit configured and dimensioned to retain a plurality of surgical fasteners, the disposable loading unit extending from the shaft and forming a juncture with the shaft, the disposable loading unit including: i) opposed split-sections pivotably connected to facilitate movement of the opposed split-sections between open and closed configurations, the opposed split sections being movable through a firing stroke from a first position to a second position and back to the first position to form a plurality of surgical fasteners; and ii) a pivot lockout member including a latch portion which extends between the opposed split-sections, the latch portion including a contact surface which interacts with a corresponding surface formed on at least one of the opposed split-sections to retain the opposed split-sections in the closed configurat

Abstract: A biopsy system is provided including a housing and a biopsy instrument operatively associated with the housing and configured and dimensioned to remove a tissue sample from a patient. A firing module is included that is detachably engageable with the housing and operatively associated with the biopsy instrument to facilitate selective rapid advancement of at least a portion of the biopsy instrument toward a targeted location with the patient. The biopsy instrument includes a tissue receiving portion. The system may include an indexing assembly disposed within the housing and configured to cooperate with the biopsy instrument to selectively orient the tissue receiving portion. The indexing assembly may include a manual gearing assembly configured for selective orientation of the tissue receiving portion. The system may include a linear advancement control assembly disposed within the housing and configured to effect linear actuation of a tubular knife member.

Abstract: An apparatus and method for the thermal treatment of tissue, e.g., prostatic tissue, with RF energy is disclosed. The apparatus includes a handle dimensioned to be grasped with a single hand of a surgeon, an elongated portion extending distally from the handle and defining a longitudinal axis, at least one electrode extending within the elongated portion and movable between a non-deployed position and a fully deployed position, and a trigger mechanism associated with the handle and having a trigger operatively connected to the one electrode. The trigger is movable to selectively and incrementally move the one electrode between the non-deployed position and the fully deployed position. A ratchet mechanism permits movement of the trigger in one direction corresponding to movement of the one electrode toward the fully deployed position while preventing movement of the trigger in a second direction.

Abstract: There are disclosed various systems and methods for installing a synthetic, artificial heart valve within a patient. One system generally includes a plurality of sutures, each suture having a staple attached to a distal end thereof; a surgical stapler for radially discharging the staples into a heart at a location adjacent a site for installing the heart valve; a support assembly for releasably supporting the plurality of sutures; and a heart valve setter assembly, the heart valve setter assembly being operable to move the heart valve into position within the site in the heart.