Patents Assigned to Univ. of CA
  • Cationized antibodies for delivery through the blood-brain barrier
    Patent number: 5004697
    Abstract: The rate of trancytosis of antibodies across the blood-brain barrier is increased by cationizing the antibodies to provide cationized antibodies having an isoelectric point of between about 8.0 to 11.0. The increased rates of transport across the blood-brain barrier makes such cationized antibodies useful for both neurodiagnostic and neuropharmaceutical purposes. Methods for preparing such cationized antibodies are disclosed.
    Type: Grant
    Filed: August 17, 1987
    Date of Patent: April 2, 1991
    Assignees: Univ. of CA, Alkermes
    Inventor: William M. Pardridge