Abstract: The present invention includes 16-HETE analogs which are agonists and antagonists of 16-HETE. The compositions may be formulated in pharmaceutically acceptable formulations. The invention also includes methods and products for inhibiting neutrophil adhesion and neutrophil aggregation using the 16-HETE agonists. One method of the invention involves the administration of a 16-HETE agonist in combination with a thrombolytic agent to a patient suffering from thromboembolic stroke.
Type:
Grant
Filed:
November 9, 2001
Date of Patent:
May 13, 2003
Assignees:
Univ. Vermont and State Agricultural College, Univ. of Texas System Board of Regents, New York Medical College
Inventors:
John R. Falck, Martin M. Bednar, Cordell E. Gross, Michael Balazy
Abstract: This invention is directed to 2-aminoalkyl-5-aminoalkylamino substituted isoquino[8,7,6-cd]indazole-6-(2H)-ones and to 2-aminoalkyl-5-aminoalkylamino substituted-isoquino[5,6,7-cd]indazole-6(2H)-ones. These compounds have been shown to have antitumor activity.
Type:
Grant
Filed:
December 7, 1994
Date of Patent:
February 18, 1997
Assignees:
Boehringer Mannheim Italia SpA, Univ. of Vermont
Inventors:
A. Paul Krapcho, Ernesto Menta, Ambrogio Oliva, Silvano Spinelli
Abstract: There is disclosed a process for controlling undesirable vegetation, espelly velvetleaf by applying Colletotrichum coccodes spores onto the undesirable vegetation or onto the situs of the undesirable vegetation. The composition including the fungus spores in an agricultural carrier as well as the growing of the fungus on solid or liquid media are also disclosed. The spores germinate, infect the undesirable vegetation and result in a pathogenic disease which kills or reduces the growth of this undesirable plant.
Type:
Grant
Filed:
July 20, 1988
Date of Patent:
July 2, 1991
Assignees:
The Royal Institution for the Advancement of Learning (McGill Univ.), The Univ. of Vermont and State Agriculturual College
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