Patents Assigned to Univ.
  • Cardiac hypertrophy factor
    Patent number: 5571893
    Abstract: Isolated CHF, isolated DNA encoding CHF, and recombinant or synthetic methods of preparing CHF are disclosed, These CHF molecules are shown to influence hypertrophic activity and neurological activity. Accordingly, these compounds or their antagonists may be used for treatment of heart failure, arrhythmic disorders, inotropic disorders, and neurological disorders.
    Type: Grant
    Filed: August 5, 1994
    Date of Patent: November 5, 1996
    Assignees: Genentech, Inc., Regents of the Univ. of California
    Inventors: Joffre Baker, Kenneth Chien, Kathleen King, Diane Pennica, William Wood
  • Method of treating inflammatory bowel disease with tributyrin
    Patent number: 5569680
    Abstract: A method for treating inflammatory bowel disease in a patient by inhibiting the production of interleukin-8 in intestinal epithelial cells by administering to said patient an enema of an effective amount of tributyrin.
    Type: Grant
    Filed: February 13, 1995
    Date of Patent: October 29, 1996
    Assignee: Trustees of the Univ. of Penna
    Inventor: Gary D. Wu
  • Preparation of homogeneous polymers using supercritical fluid solutions
    Patent number: 5567769
    Abstract: Homogeneous polymer blends are prepared from otherwise thermodynamically immiscible polymers, especially including block copolymers. Thus, polymers such as polystyrene/poly(methyl methacrylate) block copolymer or polystyrene/poly(1,2-butadiene) block copolymer are dissolved under pressure in supercritical fluid solvents such as chlorodifluoromethane and n-butane, respectively, and expanded through a fine nozzle. As the SCF solvent evaporates, the polymer deposits as a substantially homogeneous material.
    Type: Grant
    Filed: January 30, 1995
    Date of Patent: October 22, 1996
    Assignees: The Procter & Gamble Company, The Univ. of Delaware
    Inventors: Annette D. Shine, Steven D. Smith, Isao Noda
  • Elevator and speciman carrier for automated conveyor system
    Patent number: 5567386
    Abstract: An elevator for specimen carriers includes an upper housing which is removably connected to an upstream end of an upper conveyor track and a lower housing which is removably connected to a downstream end of a lower conveyor track, the conveyor tracks being vertically spaced. Each conveyor track has a moving support surface which transports a specimen carrier downstream. The elevator includes a pair of opposingly disposed lift pins operably mounted along a chain housed within the elevator, the lift pins located to engage opposingly disposed wings on each specimen carrier, to lift the specimen carrier from the lower track to the upper track. The elevator housings are adjustably connected together, to permit adjustment of the overall height of the elevator for a variety of vertically spaced tracks.
    Type: Grant
    Filed: April 7, 1995
    Date of Patent: October 22, 1996
    Assignee: Board of Regents- Univ. of NE
    Inventor: Rodney S. Markin
  • L-nucleosides for the treatment of hepatitis B-virus
    Patent number: 5567688
    Abstract: A method for the treatment of a human infected with HBV that includes administering an HBV-treatment amount of an L-nucleoside of the formula: ##STR1## wherein R is selected from the group consisting of 5-methyluracil, adenine and cytosine, and R' is hydrogen, acyl, alkyl or a monophosphate, diphosphate or triphosphate ester, or its pharmaceutically acceptable salt.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: October 22, 1996
    Assignees: Univ. of GA Research Foundation, Yale University
    Inventors: Chung K. Chu, Yung-Chi Cheng, Balakrishna S. Pai, Gang-Oing Yao
  • Method of expanded porphyrin-oligonucleotide conjugate synthesis
    Patent number: 5565552
    Abstract: The invention is directed to a method of incorporating expanded porphyrins, and particularly of incorporating a sapphyrin or a texaphyrin, before, during, or after chemical synthesis of an oligomer to form an expanded porphyrin-oligonucleotide conjugate, and particularly a sapphyrin- or texaphyrin-oligonucleotide conjugate. This method includes reacting derivatized nucleotides and a sapphyrin or a texaphyrin in a desired order in an automated or manual DNA synthesizer having a solid support to form a sapphyrin- or a texaphyrin-oligonucleotide conjugate.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 15, 1996
    Assignees: Pharmacyclics, Inc., Board of Regents, Univ. of Texas Sys.
    Inventors: Darren Magda, Jonathan L. Sessler, Brent L. Iverson, Petra I. Sansom, Shaun P. Crofts
  • Data transmission
    Patent number: 5561732
    Abstract: A device for data transmission by light has a waveguide doped with a fluorescent material. A light source is arranged to provide modulated light to enter the waveguide through an upper surface, the fluorescent material being responsive to the modulated light to emit light omnidirectionally. The emitted light is guided towards and emitted through end surfaces of the waveguide.
    Type: Grant
    Filed: September 28, 1994
    Date of Patent: October 1, 1996
    Assignee: Coventry Univ. Enterprises & Welmed Ltd.
    Inventor: Stephen Gergely
  • DNA fragment sizing and sorting by laser-induced fluorescence
    Patent number: 5558998
    Abstract: A method is provided for sizing DNA fragments using high speed detection systems, such as flow cytometry to determine unique characteristics of DNA pieces from a sample. In one characterization the DNA piece is fragmented at preselected sites to produce a plurality of DNA fragments. The DNA piece or the resulting DNA fragments are treated with a dye effective to stain stoichiometrically the DNA piece or the DNA fragments. The fluorescence from the dye in the stained fragments is then examined to generate an output functionally related to the number of nucleotides in each one of the DNA fragments. In one embodiment, the intensity of the fluorescence emissions from each fragment is linearly related to the fragment length. The distribution of DNA fragment sizes forms a characterization of the DNA piece for use in forensic and research applications.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: September 24, 1996
    Assignee: The Regents of the Univ. of California
    Inventors: Mark L. Hammond, James H. Jett, Richard A. Keller, Babetta L. Marrone, John C. Martin
  • Methods of culturing and modulating the growth of hair follicular stem cells
    Patent number: 5556783
    Abstract: A method of culturing hair follicular stem cells by isolating a subpopulation of follicular keratinocytes from the upper portion of a hair follicle, dispersing the isolated keratinocytes into a single cell suspension, and growing the dispersed isolated keratinocytes in the presence of 3T3 feeder cells is provided. A method of evaluating the efficacy of agents for modulating the activity of bulge cell populations by exposing bulge cells to an agent to be tested and comparing the response of the test cells to established controls for bulge cells is also provided. Methods of modulating the activity of hair follicular stem cells by identifying a subpopulation of follicular keratinocytes from the upper portion of a hair follicle and contracting the cells with a selected agent to stimulate growth or to selectively kill the cells is also provided.
    Type: Grant
    Filed: July 1, 1993
    Date of Patent: September 17, 1996
    Assignees: Trustees of Univ. of Penna, New York Univ.
    Inventors: Robert M. Lavker, Tung-Tien Sun, Jing-Shan Yang
  • Aqueous solution containing D.sub.1 dopamine receptor
    Patent number: 5547845
    Abstract: Cloned genes which code for the D.sub.1 dopamine receptor are disclosed. The receptors coded for by these clones bind dopamine ligands with the proper pharmacological profile and, when expressed in the cell membrane of a suitable host and so bound, stimulate adenylyl cyclase. Also disclosed are vectors comprising a cloned gene encoding a D.sub.1 -dopamine receptor, cells transformed with such vectors, and oligonucleotide probes capable of selectively hybridizing to DNA comprising a portion of a gene coding for a D.sub.1 -dopamine receptor. The cloned genes are useful for making proteins and cell membrane preparations which can be used to screen compounds for D.sub.1 -dopamine receptor binding activity, are useful in molecular biology, and are useful as diagnostic probes.
    Type: Grant
    Filed: February 15, 1994
    Date of Patent: August 20, 1996
    Assignees: Duke University, Oregon Health Sciences Univ.
    Inventors: James R. Bunzow, Olivier Civelli, David K. Grandy, Qun Y. Zhou
  • Controlling nitrogen oxide concentrations to modulate skeletal muscle contraction
    Patent number: 5545614
    Abstract: A method for inhibiting or relaxing skeletal muscle contractions and for treating disease states resulting from or exacerbated by undesirable skeletal muscle contractions by administering a skeletal muscle relaxing amount of nitroxyl ion(NO.sup.-), nitrosonium ion(NO.sup.+), nitric oxide and nitric oxide adducts or providers. A process for stimulating, improving or enhancing muscle contraction in a mammal by treating the mammal with an effective amount of (i) a nitric oxide synthase inhibitor or (ii) a nitric oxide scavenger.
    Type: Grant
    Filed: December 5, 1994
    Date of Patent: August 13, 1996
    Assignees: Duke Univ., Harvard College
    Inventors: Jonathan Stamler, Lester Kobzik
  • Process for treatment of waste stream using Scytinostroma galactinum fungus ATCC 20966
    Patent number: 5545544
    Abstract: The white rot fungus Scytinostroma galactinum strain F361 and mutants thereof are particularly effective in selectively grading the lignin component of lignin-containing materials, particularly processed wood pulps including chemical pulps, and also particularly effective in degrading lignin degradation products such as chlorinated degraded lignin by-products as found, for example, in E-1 effluents, and also in degrading chlorine-containing aromatic compounds generally as found in aqueous waste streams containing the same.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: August 13, 1996
    Assignees: Sandoz Ltd., The Regents of the Univ. of Minnesota
    Inventors: Robert A. Blanchette, Theresa S. Brush, Roberta L. Farrell, Keith A. Krisa, Chittra Mishra
  • NMR conformal solenoidal coil
    Patent number: 5543710
    Abstract: A NMR conformal solenoidal coil includes a generally cylindrical parallel-wound solenoidal coil which can be oriented at any angle within the plane transverse to the static magnetic field. The cylindrical shape has been modified to conform to fit closely over hands, wrist, and feet. One end remains circular while the opposite is oval. A diagonal winding of the conductors about the generally cylindrical form are in parallel with the diagonally cut ends of the coil form, such that the coil windings are in a plane orthogonal to the transverse plane; thereby optimizing their efficiencies.
    Type: Grant
    Filed: February 22, 1994
    Date of Patent: August 6, 1996
    Assignee: Board of Regents of Univ. of NE
    Inventor: Randall W. Jones
  • Methods of diagnosing and treating preeclampsia
    Patent number: 5543138
    Abstract: Methods are provided for the diagnosis and treatment of patients with increased risk of gestational hypertension or preeclampsia. The methods involve measuring serum M-CSF levels, and administration of M-CSF.
    Type: Grant
    Filed: March 10, 1994
    Date of Patent: August 6, 1996
    Assignees: Genetics Institute, Inc., Virginia Polytechnic Institute and State Univ.
    Inventor: James C. Keith
  • Detection of hypoxia with reagents containing 2-nitroimidazole compounds and methods of making such reagents
    Patent number: 5540908
    Abstract: Novel nitroaromatic compounds and immunogenic conjugates comprising a novel nitroaromatic compound and a carrier protein are disclosed. The invention further presents monoclonal antibodies highly specific for the claimed nitroaromatic compounds, the compounds' protein conjugates, the compounds' reductive byproducts, and adducts formed between the compounds and mammalian hypoxic cell tissue proteins. The invention is further directed to methods for detecting tissue hypoxia using immunohistological techniques, non-invasive nuclear medicinal methods, or nuclear magnetic resonance. Diagnostic kits useful in practicing the methods of claimed invention are also provided.
    Type: Grant
    Filed: August 4, 1994
    Date of Patent: July 30, 1996
    Assignees: The Trustees of the Univ. of Pennsylvania, The University of Rochester
    Inventors: Cameron J. Koch, Edith M. Lord
  • Method of control leukocyte extravasation
    Patent number: 5538724
    Abstract: Methods and compositions are described for modulating trafficking of leukocytes to endothelial cells involving the binding of homing receptors and addressins. Particularly, compositions are provided which can inhibit the interaction between the homing receptor and addressin or provide for directing specific molecules associated with diagnosis or treatment, where the molecules bind to the addressins.
    Type: Grant
    Filed: December 19, 1991
    Date of Patent: July 23, 1996
    Assignee: The Board of Trustees for the Leland Stanford Junior Univ.
    Inventors: Eugene C. Butcher, Philip R. Streeter, Ellen L. Berg
  • Melanin compositions and uses thereof and resulting products
    Patent number: 5538752
    Abstract: Compositions comprising melanin or melanin precursors are useful for preventing or controlling decay of substrates such as cellulosic and other porous organic substrates. The compositions provide useful wood preservatives, wound dressings, and the like. In one embodiment, the compositions comprise melanin complexed with metal ions, particularly copper. The compositions may be applied as penetrating or surface treatments. Certain melanins are also particularly useful for removing metal ions from liquids.
    Type: Grant
    Filed: February 13, 1995
    Date of Patent: July 23, 1996
    Assignees: Regents of the Univ. of Minnesota, Sandoz Ltd.
    Inventors: Robert A. Blanchette, Theresa S. Brush, Roberta L. Farrell
  • Central control apparatus for an automated laboratory conveyor system
    Patent number: 5529166
    Abstract: A central control apparatus for an automated laboratory conveyor system includes a conveyor track arranged in a closed loop to continuously transport a specimen carrier having a laboratory specimen therein. A receiving station is provided along the track which is connected to a laboratory information system having identification and instructional data with respect to a particular specimen, and which marks an individual specimen carrier to identify the carrier with a particular specimen as it is conveyed throughout the conveyor system. The receiving station and an archiving station are both connected to a central control unit which is connected to the conveyor track and the laboratory information system to control the entire automated laboratory conveyor system. At least one work station is located along the conveyor track for performing a predetermined test on a particular specimen.
    Type: Grant
    Filed: March 15, 1994
    Date of Patent: June 25, 1996
    Assignee: Board of Regents - Univ of Nebraska
    Inventors: Rodney S. Markin, Eldon L. Tackett, Stephen J. Hoskinson
  • Method and composition for treating obesity comprising dehydroepiandrosterone (DHEA), or a derivative thereof, and an anorectic agent
    Patent number: 5527788
    Abstract: The invention describes a method and composition for treating obesity or related disorders in animals using an anorectic agent and dehydroepiandrosterone (DHEA). The composition effectively diminishes caloric intake, may alter metabolism, weight gain, or a combination thereof.
    Type: Grant
    Filed: January 18, 1994
    Date of Patent: June 18, 1996
    Assignee: Louisiana State Univ. Medical Center Foundation
    Inventors: Frank Svec, Johnny Porter
  • Colonic drug delivery system
    Patent number: 5525634
    Abstract: A colonic delivery system for delivering a drug to the colon is provided. The system comprises a drug in combination with a matrix, wherein the matrix comprises a saccharide-containing polymer. According to the invention, the matrix is resistant to chemical and enzymatic degradation in the stomach and small intestine. The matrix is degraded in the colon by bacterial enzymatic action, and the drug is released. The system is useful for targeting drugs to the colon in order to treat colonic disease. The system is also useful for enteric administration of drugs such as proteins and peptides which are otherwise degraded in the stomach and small intestine.
    Type: Grant
    Filed: February 10, 1994
    Date of Patent: June 11, 1996
    Assignees: Perio Products, Ltd., Yissum Research Development Co. of the Hebrew Univ. of Jerusalem
    Inventors: Amnon Sintov, Abraham Rubinstein