Patents Assigned to UNIVERCELLS TECHNOLOGIES S.A.
  • Patent number: 12152231
    Abstract: The current disclosure concerns a system for producing biomolecules comprising a bioreactor including a chamber (1) suitable for receiving a liquid comprising cells and viral particles; and a concentrator (2), wherein said concentrator is equipped with a retentate conduit (300, 303) suitable for collecting said retentate and facilitating recirculating of the retentate to an input of said bioreactor or to an input of an intermediate vessel (4) positioned between said concentrator and said bioreactor. In a second and third aspect the disclosure concerns a method for producing biomolecules and the use of the disclosed system for the production of biomolecules.
    Type: Grant
    Filed: September 27, 2018
    Date of Patent: November 26, 2024
    Assignee: UNIVERCELLS TECHNOLOGIES S.A.
    Inventors: José Castillo, Bastien Mairesse, Laetitia De Viron, Jean-Christophe Drugmand
  • Patent number: 12036549
    Abstract: The invention provides a method and a system for the production of viruses or virus derived products. The system comprises a containment enclosure provided with a single entry means and a single exit means which are movable between a closed position and an open position. The containment enclosure comprises at least one production unit comprising at least one bioreactor for culturing the virus, said bioreactor is provided with at least one inlet and at least one outlet; at least one purification unit fluidly connected to the production unit and comprising at least one purification means having at least one inlet and at least one outlet. The system further comprises at least one inactivation and/or at least one gas decontamination unit. The containment enclosure comprises at least one process control device connected to the exit means. The movement of the exit means from the closed position to the open position is controllable by said process control device.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: July 16, 2024
    Assignee: UNIVERCELLS TECHNOLOGIES S.A.
    Inventors: José Castillo, Bastien Mairesse
  • Patent number: 11946032
    Abstract: A sampler for use with a bioreactor for growing a cell culture is disclosed. In one embodiment, the bioreactor includes a structured fixed bed including a removable sample portion for recovering a sample of cells from the cell culture. Related apparatuses and methods are also disclosed.
    Type: Grant
    Filed: March 18, 2019
    Date of Patent: April 2, 2024
    Assignee: UNIVERCELLS TECHNOLOGIES S.A.
    Inventors: José Castillo, Bastien Mairesse, Alex Chatel, Sebastien Jean-Pierre Michel Rodriguez, Alexandre VAnhaver
  • Patent number: 11827873
    Abstract: The invention provides a structured cell growth matrix or assembly comprising a one or more spacer layers and one or more cell immobilization layers. The invention further provides a bioreactor comprising said matrix or assembly.
    Type: Grant
    Filed: July 20, 2020
    Date of Patent: November 28, 2023
    Assignee: UNIVERCELLS TECHNOLOGIES S.A.
    Inventors: José Castillo, Bastien Mairesse, Quentin Vanwalleghem
  • Patent number: 11680237
    Abstract: An apparatus for culturing cells includes a bioreactor. The bioreactor may be modular and may include in a chamber a fixed bed, such as an unstructured or structured fixed bed (such as a spiral bed) for culturing cells, with a return column arranged centrally within the chamber. The modular bioreactor may include a plurality of structured fixed bed arranged in a stacked configuration. The modular bioreactor may include an outer casing forming a space for conditioning (e.g., insulating, heating, cooling) at least a chamber in which cells are cultured. The bioreactor may also include an impeller with radially curved blades, and may also suspend the impeller so that it may move from side-to-side and align with an external drive. Related methods are also disclosed.
    Type: Grant
    Filed: August 15, 2022
    Date of Patent: June 20, 2023
    Assignee: UNIVERCELLS TECHNOLOGIES S.A.
    Inventors: José Castillo, Bastien Mairesse, Sebastien Jean-Pierre Michel Rodriguez
  • Patent number: 10876090
    Abstract: The invention provides a structured cell growth matrix or assembly comprising a one or more spacer layers and one or more cell immobilization layers. The invention further provides a bioreactor comprising said matrix or assembly.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: December 29, 2020
    Assignee: UNIVERCELLS TECHNOLOGIES S.A.
    Inventors: José Castillo, Bastien Mairesse, Quentin Vanwalleghem