Abstract: A sampler for use with a bioreactor for growing a cell culture is disclosed. In one embodiment, the bioreactor includes a structured fixed bed including a removable sample portion for recovering a sample of cells from the cell culture. Related apparatuses and methods are also disclosed.
Type:
Grant
Filed:
March 18, 2019
Date of Patent:
April 2, 2024
Assignee:
UNIVERCELLS TECHNOLOGIES S.A.
Inventors:
José Castillo, Bastien Mairesse, Alex Chatel, Sebastien Jean-Pierre Michel Rodriguez, Alexandre VAnhaver
Abstract: The invention provides a structured cell growth matrix or assembly comprising a one or more spacer layers and one or more cell immobilization layers. The invention further provides a bioreactor comprising said matrix or assembly.
Type:
Grant
Filed:
July 20, 2020
Date of Patent:
November 28, 2023
Assignee:
UNIVERCELLS TECHNOLOGIES S.A.
Inventors:
José Castillo, Bastien Mairesse, Quentin Vanwalleghem
Abstract: An apparatus for culturing cells includes a bioreactor. The bioreactor may be modular and may include in a chamber a fixed bed, such as an unstructured or structured fixed bed (such as a spiral bed) for culturing cells, with a return column arranged centrally within the chamber. The modular bioreactor may include a plurality of structured fixed bed arranged in a stacked configuration. The modular bioreactor may include an outer casing forming a space for conditioning (e.g., insulating, heating, cooling) at least a chamber in which cells are cultured. The bioreactor may also include an impeller with radially curved blades, and may also suspend the impeller so that it may move from side-to-side and align with an external drive. Related methods are also disclosed.
Type:
Grant
Filed:
August 15, 2022
Date of Patent:
June 20, 2023
Assignee:
UNIVERCELLS TECHNOLOGIES S.A.
Inventors:
José Castillo, Bastien Mairesse, Sebastien Jean-Pierre Michel Rodriguez
Abstract: The invention provides a structured cell growth matrix or assembly comprising a one or more spacer layers and one or more cell immobilization layers. The invention further provides a bioreactor comprising said matrix or assembly.
Type:
Grant
Filed:
March 28, 2018
Date of Patent:
December 29, 2020
Assignee:
UNIVERCELLS TECHNOLOGIES S.A.
Inventors:
José Castillo, Bastien Mairesse, Quentin Vanwalleghem