Abstract: A photonic device may include a lower cladding layer and a device layer. The device layer may include a first waveguide supporting TE and TM light, and a second waveguide, where a portion of a second waveguide core is proximate to a first waveguide core to provide evanescent coupling. The first waveguide core is formed from one of a first core structure or a second core structure, and the second waveguide core is formed from the other structure. The first core structure has an index of refraction nM. The second core structure is formed as alternating layers providing an effective index of refraction for TE polarized light nTE and an effective index of refraction for TM polarized light nTM, where nTM<nM<nTE such that one of TM or TE light is preferentially evanescently coupled between the first waveguide and the second waveguide.

Abstract: In one aspect, the invention relates to substituted 2-hydroxy-4-(2-(phenylsulfonamido)acetamido)benzoic acid analogs, derivatives thereof, and related compounds, which are useful as inhibitors of STAT protein activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation associated with a STAT protein activity dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.