Patents Assigned to Univeristy of Cincinnati
  • Patent number: 9951024
    Abstract: Provided are inhibitors of Rho GTPase activation, and, in particular, compounds that inhibit RhoA activation by an RhoGEF. Also provided are related pharmaceutical compositions and methods. Also provided are methods of inhibiting Rho GTPase activation. Also provided are methods of screening for compounds that inhibit Rho GTPase activation by a RhoGEF.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: April 24, 2018
    Assignees: Children's Hospital Medical Center, Univeristy of Cincinnati
    Inventors: Yi Zheng, Matthew Wortman
  • Publication number: 20180042841
    Abstract: We disclose a composition comprising an echogenic liposome (ELIP) having an exterior surface, an interior surface, and at least one bilayer comprising at least one lipid selected from the group consisting of saturated phospholipids, unsaturated phospholipids, mixed phospholipids, and cholesterol, and a thrombolytic compound trapped by the ELIP. We also disclose a method of treating a medical condition in a patient characterized by a thrombus in the patient's vasculature, comprising administering to the patient the composition in an amount effective to reduce the size of the thrombus.
    Type: Application
    Filed: October 10, 2017
    Publication date: February 15, 2018
    Applicants: Board of Regents, The University of Texas System, Univeristy of Cincinnati
    Inventors: Susan T. Laing, Shaoling Huang, David D. McPherson, Christy K. Holland, Melvin E. Klegerman