Patents Assigned to Univeristy of Iowa Research Foundation
  • Publication number: 20100261646
    Abstract: Biodegradable polymeric microparticle compositions containing one or more active agents, especially those useful for treating or preventing or one or more diseases or disorders of the eye, and methods of making and using thereof, are described. The microsphere compositions release an effective amount of the one or more active agents for a period greater than 14 days in vivo, preferably greater than 60 days in vivo, more preferably up to 73 days in vivo, more preferably greater than 90 days in vivo, even more preferably over 100 days in vivo, and most preferably greater than 107 days in vivo. In a preferred embodiment, the microparticle compositions contain one or more active agents useful for managing elevated intraocular pressure (TOP) in the eye. In one embodiment, the microspheres are formed from polylactide-co-glycolide (“PLGA”); in another embodiment, the microspheres are formed from a blend PLGA and poly lactic acid (“PLA”).
    Type: Application
    Filed: June 18, 2008
    Publication date: October 14, 2010
    Applicants: YALE UNIVERSITY, UNIVERISTY OF IOWA RESEARCH FOUNDATION
    Inventors: Erin Lavik, Young H. Kwon, Markus Kuehn, Sandeep Saluja, James Bertram, John Huang
  • Patent number: 7439270
    Abstract: Spinal anesthetics for intrathecal administration to produce spinal anesthesia are provided with use of 6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisoquinolone-3-carboxylic acid or its pharmaceutically active analogues.
    Type: Grant
    Filed: June 7, 2006
    Date of Patent: October 21, 2008
    Assignee: Univeristy of Iowa Research Foundation
    Inventor: Timothy J. Brennan
  • Patent number: 5458749
    Abstract: A process and apparatus are described herein which provide for the automated processing of electrophoresed gels having biological material thereon within a single processing chamber. The described apparatus is implemented by control sequencing software to stain process electrophoretic gels by contact with a series of recirculated solutions including fixing, rinsing, staining, and developing solutions.
    Type: Grant
    Filed: May 2, 1994
    Date of Patent: October 17, 1995
    Assignee: Univeristy of Iowa Research Foundation
    Inventors: Edwin M. Stone, Brian E. Nichols