Patents Assigned to Univeristy of Massachusetts
  • Patent number: 10280418
    Abstract: The invention relates to inhibitory nucleic acids and rAAV-based compositions, methods and kits useful for treating Amyotrophic Lateral Sclerosis.
    Type: Grant
    Filed: March 18, 2015
    Date of Patent: May 7, 2019
    Assignee: Univeristy of Massachusetts
    Inventors: Christian Mueller, Robert H. Brown, Jr.
  • Patent number: 8003129
    Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.
    Type: Grant
    Filed: April 18, 2008
    Date of Patent: August 23, 2011
    Assignees: University of Washington, Univeristy of Massachusetts
    Inventors: Allan S. Hoffman, Patrick Stayton, Oliver W. Press, Niren Murthy, Chantal Lackey Reed, Lawrence A. Crum, Pierre D. Mourad, Tyrone M. Porter, David Tirrell
  • Patent number: 7985583
    Abstract: The invention relates to various intraflagellar transport (IFT) polypeptides and the nucleic acids that encode them. The new IFT particle polypeptides and nucleic acids can be used in a variety, of diagnostic, screening, and therapeutic methods.
    Type: Grant
    Filed: June 9, 2009
    Date of Patent: July 26, 2011
    Assignees: Univeristy of Massachusetts, Yale University
    Inventors: George B. Witman, Gregory J. Pazour, Joel L. Rosenbaum, Douglas G. Cole
  • Patent number: 7736860
    Abstract: Described are methods and compositions that inhibit IL-1 signalling for the treatment of acute inflammatory response to cell necrosis, and the attendant collateral tissue damage.
    Type: Grant
    Filed: November 9, 2007
    Date of Patent: June 15, 2010
    Assignee: Univeristy of Massachusetts
    Inventors: Kenneth L. Rock, Chun-Jen Chen