Abstract: The present invention relates, in part, to targeted chimeric proteins with beneficial therapeutic effects, including, for example, effects mediated by chimeric proteins which comprise modified signaling agents two or more targeting moieties. Methods of treatment and pharmaceutical compositions comprising the chimeric proteins are also provided. The present invention finds use in the treatment of various disease and disorders.
Type:
Grant
Filed:
February 6, 2018
Date of Patent:
February 15, 2022
Assignees:
VIB VZW, Centre National de la Recherche Scientifique, Univeriteit Gent, Universite de Montpellier
Inventors:
Jan Tavernier, Jose Van Der Heyden, Genevieve Garcin, Gilles Uze, Yann Bordat