Abstract: The present disclosure relates to the generation of food grade sugar modified 1-MCP nanobubbles ranging in size from 50 to 600 nm. These nanobubbles have a high degree of stability while in aqueous solution and can inhibit the action of ethylene in different biological processes. In addition, they can reduce the action of ethylene in plant metabolism, making the plant less susceptible to water stress, low temperature stress, and stress from soil conditions, among others. This disclosure also relates to the method of preparing sugar modified 1-MCP nanobubbles, their different uses and applications.
Type:
Grant
Filed:
March 13, 2020
Date of Patent:
April 16, 2024
Assignees:
Nanotec S. A., Universidad Andrés Bello
Abstract: A pharmaceutical composition comprising: a) an effective amount of one or more lytic bacteriophages specific against Fusobacterium nucleatum selected from Fnp?02-14, Fnp?11 and Fnn?107 or mixtures of them; and b) one or more pharmaceutically acceptable carrier and/or excipients. Method for preventing and/or treating diseases associated with Fusobacterium nucleatum and the use of the pharmaceutical composition for treating a disease associated with Fusobacterium nucleatum of the oral cavity such as periodontal disease, among others.
Type:
Grant
Filed:
April 21, 2021
Date of Patent:
May 23, 2023
Assignee:
UNIVERSIDAD ANDRÉS BELLO
Inventors:
Waldemar M. Bittner Ortega, Pamela I. Machuca Valenzuela, Valeska S. Herrera Sanhueza, Ignacio A. Fuentevilla Morgado
Abstract: A sequential or cascading predictive control method is provided, including first solving a cost function and then a second cost function for two or more control objectives. The method includes separating the cost function into at least two or more cost functions, depending on the number of defined control objectives. The method additionally includes controlling a first variable with a unitary cost function, a single term or nature of the control objectives. The method also includes determining the possible states that minimize the cost of the first objective to be controlled. Considering only the options given through this determination, a second variable is controlled with a cost function that minimizes the cost function thereof.
Type:
Grant
Filed:
September 15, 2017
Date of Patent:
November 1, 2022
Assignee:
UNIVERSIDAD ANDRES BELLO
Inventors:
Margarita Norambuena Valdivia, Jose Rodriguez Perez
Abstract: A pharmaceutical composition comprising: a) an effective amount of one or more lytic bacteriophages specific against Fusobacterium nucleatum selected from Fnp?02-14, Fnp?11 and Fnn?107 or mixtures of them; and b) one or more pharmaceutically acceptable carrier and/or excipients. Method for preventing and/or treating diseases associated with Fusobacterium nucleatum and the use of the pharmaceutical composition for treating a disease associated with Fusobacterium nucleatum of the oral cavity such as periodontal disease, among others.
Type:
Application
Filed:
April 21, 2021
Publication date:
September 30, 2021
Applicant:
UNIVERSIDAD ANDRÉS BELLO
Inventors:
Waldemar M. Bittner Ortega, Pamela I. Machuca Valenzuela, Valeska S. Herrera Sanhueza, Ignacio A. Fuentevilla Morgado
Abstract: A multilevel converter allowing the reduction of volume and accessibility to the control and transformation of electric power, including at least two basic cells and having: a) a first power switch that interconnects a positive bus between the two basic cells connected in cascade each other; b) a second power switch that interconnects a negative bus between two basic cells connected in cascade each other and c) a capacitor with a third power switch, connected in series and interconnected between the positive and negative bus.
Type:
Grant
Filed:
September 20, 2017
Date of Patent:
May 25, 2021
Assignees:
Universidad Andres Bello, Universidad Tecnica Federico Santa Maria
Inventors:
Margarita Norambuena Valdivia, José Rodriguez Pérez, Samir Kouro Renaer
Abstract: A multilevel converter operating with fewer components saving costs, losses, size and weight, allowing the reduction of volume and accessibility to the control and transformation of electric power, comprising at least a basic cell formed by: a) a first power switch that interconnects the positive bus between said at least one basic cell and at least another basic cell connected in cascade each other and/or a basic cell and a continuous voltage source; b) a second power switch that interconnects the negative bus between said at least one basic cell and at least another basic cell connected in cascade each other; and/or a basic cell and the continuous voltage source of point a); and c) a capacitor with a third power switch, both of them being connected in series each other and interconnected between the positive and negative bus.
Type:
Application
Filed:
September 20, 2017
Publication date:
January 23, 2020
Applicants:
UNIVERSIDAD ANDRÉS BELLO, UNIVERSIDAD TÉCNICA FEDERICO SANTA MARÍA
Inventors:
Margarita NORAMBUENA VALDIVIA, José RODRIGUEZ PÉREZ, Samir KOURO RAENER
Abstract: A controlled release system includes a polymeric support, wherein the polymeric support is biodegradable; a polymeric matrix, wherein the polymeric matrix includes polyhydroalkanoate; and encapsulated gases or volatiles; and a controlled release system includes a polymeric support; a polymeric matrix, wherein the polymeric matrix includes (poly-3-hydroxybutyrate-co-3-hydroxyvalerate) and poly (?-caprolactone); and encapsulated gases or volatiles.
Type:
Grant
Filed:
July 23, 2014
Date of Patent:
October 22, 2019
Assignee:
Universidad Andrés Bello
Inventors:
Luis Velásquez, Reinaldo Campos, Danilo Gonzalez, Rubén Polanco
Abstract: The present invention is related to the use of compounds or pharmaceutically acceptable salts thereof that modulate astrocytic release of substances through connexin and pannexin hemichannels, for the treatment of psychiatric disorders. Compounds or pharmaceutically acceptable salts thereof used in the present invention comprise any compound that differentially modulates, blocks, opens, inhibits, and/or activates connexin and/or pannexin hemichannels from astrocytes while not affecting gap junctions. The invention is also related to a method for treating psychiatric disorders, comprising administering to a mammal or human a therapeutically effective amount of a compound or a pharmaceutically acceptable salt thereof, that modulates astrocytic release of substances through connexin and pannexin hemichannels. Pharmaceutical compositions and a screening method are also considered in the present invention.
Type:
Grant
Filed:
May 31, 2013
Date of Patent:
January 30, 2018
Assignees:
Universidad Andres Bello, Universiteit Gent, Katholieke Universiteit Leuven, Ku Leuven R & D
Inventors:
Jimmy Stehberg Liberman, Luc Gilbert Leybaert Sinia, Geert Albert Bultynck Demets, Mauricio Antonio Retamal Lucero, Fernando Danilo Gonzalez Nilo