Abstract: In one aspect, provided herein is a nanocarrier composition for formulating a hydrophilic and aromatic low molecular-weight drug (HALMD), the composition comprising: an aromatic polymer; and a hydrophilic and aromatic low molecular-weight drug (HALMD); wherein the aromatic polymer has a positive or negative charge or is a zwitterion, and the hydrophilic and aromatic low molecular-weight drug (HALMD) has an opposing positive or negative charge or is a zwitterion; and wherein the composition has a size of between 50-400 nm and optionally, a zeta potential of from +100 to ?100 mV. A method for preparing the nanocarrier composition, as well as pharmaceutical compositions and therapeutic uses thereof, are also disclosed.
Type:
Grant
Filed:
May 29, 2020
Date of Patent:
August 16, 2022
Assignees:
UNIVERSIDAD DE CHILE, UNIVERSIDAD AUSTRAL DE CHILE
Inventors:
Felipe Andrés Oyarzún Ampuero, Ignacio Moreno Villoslada, Maria Gabriela Villamizar Sarmiento, Elton Fabian Molina Soto
Abstract: The present invention relates to a formulation useful to control Listeria monocytogenes that comprises three new lactic acid bacteria, namely Carnobacterium maltaromaticum ATCC® PTA-9380, C. maltaromaticum ATCC® PTA-9381 and Enterococcus mundtii ATCC® PTA-9382 together with the bacteriocin nisin. This formulation is obtained from Inactivated Fermentates (IF) of these strains plus nisin and is designed to be used in the food industry. This formulation is used as an agent with tested antagonistic and bactericidal action against the pathogen Listeria monocytogenes, the microorganism that causes listeriosis, a food-borne disease, in humans. Based on this formulation, 2 surface sanitizing products can be obtained, a liquid and a solid. Both surface sanitizers can be applied to sanitize equipments, devices, working surfaces, gutters and drainages, especially in the food industry.
Type:
Grant
Filed:
February 26, 2010
Date of Patent:
November 22, 2011
Assignee:
Universidad Austral de Chile
Inventors:
Renate Paula Schobitz Twele, Luigi Ciampi Panno, Marcia Enriqueta Costa Lobo, Carmen Susana Brito Contreras, Juan Ricardo Fuentes Perez, Mariela Horzella Rademacher, Yanina Iveth Nahuelquin Rios, Cristina del Carmen Vergara Hinostroza
Abstract: The present invention relates to a formulation useful to control Listeria monocytogenes that comprises three new lactic acid bacteria, namely Carnobacterium maltaromaticum ATCC® PTA-9380, C. maltaromaticum ATCC® PTA-9381 and Enterococcus mundtii ATCC® PTA-9382 together with the bacteriocin nisin. This formulation is obtained from Inactivated Fermentates (IF) of these strains plus nisin and is designed to be used in the food industry. This formulation is used as an agent with tested antagonistic and bactericidal action against the pathogen Listeria monocytogenes, the microorganism that causes listeriosis, a food-borne disease, in humans. Based on this formulation, 2 surface sanitizing products can be obtained, a liquid and a solid. Both surface sanitizers can be applied to sanitize equipments, devices, working surfaces, gutters and drainages, especially in the food industry.
Type:
Application
Filed:
February 26, 2010
Publication date:
September 23, 2010
Applicant:
Universidad Austral de Chile
Inventors:
Renate Paula Schobitz Twele, Luigi Ciampi Panno, Marcia Enriqueta Costa Lobo, Carmen Susana Brito Contreras, Juan Ricardo Fuentes Perez, Mariela Horzella Rademacher, Yanina Iveth Nahuelquin Rios, Cristina del Carmen Vergara Hinostroza
Abstract: The present application is directed to a new Bacillus subtilis strain deposited under the access number ATCC® PTA-8805, to bioproduct formulations comprising viable cells of the new strain, which can be encapsulated or in a concentrated liquid form, and to the use of these bioproducts to biologically control and decrease the incidence of Rhizoctonia solani, a plant pathogen that attacks economically important crops. The bioproducts are applied in encapsulated form directly over tubers or spraying a concentrated liquid form diluted in water over a plantation, and both formulations are applied in covered furrows.
Type:
Application
Filed:
January 22, 2009
Publication date:
August 27, 2009
Applicant:
Universidad Austral de Chile
Inventors:
Luigi Ciampi Panno, Juan Ricardo Fuentes Perez, Marcia Enriqueta Costa Lobo, Juan Pedro Nissen Mutzenbecher, Renate Paula Schobitz Twele, Mauricio Ivan Schoebitz Cid, Patricia Isabel Aguila Torres, Cristina del Vergara Hinostroza