Patents Assigned to UNIVERSIDAD AUTÓNOMA DE MADRID
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Patent number: 9976170Abstract: The present invention relates to a method for evaluating the integrity of the cell wall of the bacteria present in a culture in the presence of an antibiotic acting on the bacterial cell wall which, from a practical point of view, allows quickly determining if a bacterium is sensitive or resistant to an antibiotic acting on the bacterial cell wall. Likewise, the present invention also relates to a lysis solution applicable in the preceding method, specifically affecting bacteria having the cell wall damaged by the action of an antibiotic acting on the bacterial cell wall, which allows distinguishing bacteria sensitive to said antibiotic from those resistant to said antibiotic.Type: GrantFiled: July 26, 2012Date of Patent: May 22, 2018Assignee: UNIVERSIDAD AUTONOMA DE MADRIDInventors: Jose Luis Fernandez Garcia, Jaime Gosalvez Berenguer, German Bou Arevalo, Maria Tamayo Novas, Rebeca Santiso Brandariz
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Publication number: 20170209496Abstract: Provided herein are novel methods and composition utilizing adipose tissue-derived stromal stem cells for treating fistulae.Type: ApplicationFiled: March 20, 2017Publication date: July 27, 2017Applicants: TiGenix, S.A.U., Universidad Autónoma de MadridInventors: María Gema FERNÁNDEZ MIGUEL, Manuel Ángel GONZÁLEZ DE LA PEÑA, Rosa Ana GARCÍA CASTRO, Mariano GARCÍA ARRANZ, Damián GARCÍA OLMO
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Publication number: 20170189452Abstract: Provided herein are novel methods and compositions utilizing adipose tissue-derived stromal stem cells for treating fistulae.Type: ApplicationFiled: March 23, 2017Publication date: July 6, 2017Applicants: TiGenix, S.A.U., Universidad Autónoma de MadridInventors: María Gema FERNÁNDEZ MIGUEL, Manuel Ángel GONZÁLEZ DE LA PEÑA, Rosa Ana GARCÍA CASTRO, Mariano GARCÍA ARRANZ, Damián GARCÍA OLMO
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Publication number: 20170189451Abstract: Provided herein are novel methods and composition utilizing adipose tissue-derived stromal stern cells for treating fistulae.Type: ApplicationFiled: March 20, 2017Publication date: July 6, 2017Applicants: TiGenix, S.A.U., Universidad Autónoma de MadridInventors: María Gema FERNÁNDEZ MIGUEL, Manuel Ángel GONZÁLEZ DE LA PEÑA, Rosa Ana GARCÍA CASTRO, Mariano GARCÍA ARRANZ, Damián GARCÍA OLMO
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Patent number: 9212391Abstract: The present invention relates to a process for determining the DNA integrity in microorganisms and a kit for evaluating the DNA integrity therein. Due to the fact that cell death means DNA fragmentation, with the present process the DNA fragmentation levels in microorganisms can be clearly discriminated in a simple, quick and accurate manner.Type: GrantFiled: July 23, 2013Date of Patent: December 15, 2015Assignee: UNIVERSIDAD AUTONOMA DE MADRIDInventors: Jaime Gosalvez Berenguer, Jose Luis Fernandez Garcia, Vicente Goyanes Villaescusa, German Bau Arevalo, Lourdes Muriel Rios, Monica Cartelle Gestal
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Patent number: 9096554Abstract: The present invention relates to compounds with a benzoxadiazolyl amine structure which are capable of inhibiting the activation or the biological activity of p38 mitogen-activated protein kinase (MAPK) and the use thereof in the treatment of a disease that can be alleviated by means of inhibiting the activation or the biological activity of said p38 MAPK, for example, an inflammatory disease or a disease presenting with pain.Type: GrantFiled: October 31, 2012Date of Patent: August 4, 2015Assignee: UNIVERSIDAD AUTÓNOMA DE MADRIDInventors: Federico Mayor Menéndez, Cristina Murga Montesinos, Pedro Manuel Campos Muelas, Jacoba Johana Heijnen, Anna Maria Agnes Antonius Kavelaars, Antonio Morreale de León, Rubén Gil Redondo
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Patent number: 9091704Abstract: The invention relates to a control method having at least two control loops for a scanning microscope provided with a microlever and an actuator suitable for energizing the microlever, in which a first loop maintains as a controlled variable the oscillation amplitude of the microlever and as a manipulated variable the amplitude of the electric signal supplied to the actuator, and a second loop uses as a controlled variable the amplitude of the aforementioned electric signal and as a manipulated variable the tip-sample distance. Said procedure makes it possible to ignore changes of sign in the tip-sample interaction.Type: GrantFiled: October 10, 2012Date of Patent: July 28, 2015Assignee: UNIVERSIDAD AUTONOMA DE MADRIDInventors: David Martinez Martin, Miriam Jaafar Ruiz-Castellanos, Julio Gomez Herrero
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Patent number: 8999709Abstract: Provided herein are novel methods and compositions utilizing adipose tissue-derived stromal stem cells for treating fistulae.Type: GrantFiled: May 16, 2006Date of Patent: April 7, 2015Assignees: Tigenix, S.A.U., Universidad Autonoma de MadridInventors: María Gema Fernández Miguel, Manuel Angel González de la Peña, Rosa Ana García Castro, Mariano García Arranz, Damián García Olmo
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Publication number: 20140206573Abstract: The present invention relates to a method for evaluating the integrity of the cell wall of the bacteria present in a culture in the presence of an antibiotic acting on the bacterial cell wall which, from a practical point of view, allows quickly determining if a bacterium is sensitive or resistant to an antibiotic acting on the bacterial cell wall. Likewise, the present invention also relates to a lysis solution applicable in the preceding method, specifically affecting bacteria having the cell wall damaged by the action of an antibiotic acting on the bacterial cell wall, which allows distinguishing bacteria sensitive to said antibiotic from those resistant to said antibiotic.Type: ApplicationFiled: July 26, 2012Publication date: July 24, 2014Applicant: UNIVERSIDAD AUTONOMA DE MADRIDInventors: José Luis Fernandesz Garcia, Jaime Gosalvez Berenguer, German Bou Arevalo, María Tamaoyo Novas, Rebeca Santisto Brandariz
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Patent number: 8785416Abstract: The present invention relates to the use of a series of sulphated disaccharides for the preparation of a medicament for the treatment or prevention of a neurodegenerative and/or neurovascular disease, of a traumatic brain injury or of a traumatic spinal cord injury. The present invention also relates to the use of said sulphated disaccharides for the preparation of a neuroprotective medicament or of an antioxidant medicament. The neurodegenerative and/or neurovascular diseases are preferably: Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and stroke.Type: GrantFiled: December 22, 2010Date of Patent: July 22, 2014Assignees: Bioiberica, S.A., Universidad Autonoma de MadridInventors: Josep Verges Milano, Antonio Garcia Garcia, Ramon Ruhi Roura, Eulalia Montell Bonaventura, Manuela Garcia Lopez, Carlos Raul Alaez Verson, Josep Escaich Ferrer, Javier Egea Maiquez, Pilar Negredo Madrigal, Silvia Lorrio Gonzalez
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Publication number: 20140072539Abstract: Provided herein are novel methods and compositions utilizing adipose tissue-derived stromal stem cells for treating fistulae.Type: ApplicationFiled: September 3, 2013Publication date: March 13, 2014Applicants: TIGENIX, S.A.U., Universidad Autonoma de Madrid Ciudad Universitario de CantoblancoInventors: Maria Gema Fernandez Miguel, Manuel Angel Gonzalez De La Pena, Rosa Ana Garcia Castro, Mariano Garcia Arranz, Damian Garcia-Olmo
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Publication number: 20140024031Abstract: The present invention relates to a process for determining the DNA integrity in microorganisms and a kit for evaluating the DNA integrity therein. Due to the fact that cell death means DNA fragmentation, with the present process the DNA fragmentation levels in microorganisms can be clearly discriminated in a simple, quick and accurate manner.Type: ApplicationFiled: July 23, 2013Publication date: January 23, 2014Applicant: Universidad Autonoma de MadridInventors: Jaime Gosalvez Berenguer, José Luis Fernandez Garcia, Vicente Goyanes Villaescusa, German Bau Arevalo, Lourdes Muriel Rios, Monica Cartelle Gestal
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Patent number: 8492086Abstract: The invention relates to a method for determining DNA integrity in microorganisms and to a kit for evaluating DNA integrity in same. Since cell death results in DNA fragmentation, the inventive method can be used to determine DNA fragmentation levels in microorganisms clearly, simply, quickly and precisely.Type: GrantFiled: November 8, 2007Date of Patent: July 23, 2013Assignee: Universidad Autonoma de MadridInventors: Jaime Gosalvez Berenguer, José Luis Fernandez Garcia, Vicente Goyanes Villaescusa, German Bau Arevalo, Lourdes Muriel Rios, Monica Cartelle Gestal
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Publication number: 20120309707Abstract: The present invention relates to the use of a series of sulphated disaccharides for the preparation of a medicament for the treatment or prevention of a neurodegenerative and/or neurovascular disease, of a traumatic brain injury or of a traumatic spinal cord injury. The present invention also relates to the use of said sulphated disaccharides for the preparation of a neuroprotective medicament or of an antioxidant medicament. The neurodegenerative and/or neurovascular diseases are preferably: Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and stroke.Type: ApplicationFiled: December 22, 2010Publication date: December 6, 2012Applicants: UNIVERSIDAD AUTONOMA DE MADRID, BIOIBERICA, S.A.Inventors: Josep Verges Milano, Antonio Garcia Garcia, Ramon Ruhi Roura, Eulalia Montell Bonaventura, Manuela Garcia Lopez, Carlos Raul Alaez Verson, Josep Escaich Ferrer, Javier Egea Maiquez, Pilar Negredo Madrigal, Silvia Lorrio Gonzalez
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Publication number: 20120213750Abstract: Provided herein are novel methods and compositions utilizing adipose tissue-derived stromal stem cells for treating fistulae.Type: ApplicationFiled: April 26, 2012Publication date: August 23, 2012Applicants: Universidad Autonoma De Madrid Ciudad Universitaria de CantoblancoInventors: Maria Gema Fernandez Miguel, Manuel Angel Gonzalez de la Peña, Rosa Ana Garcia Castro, Mariano Garcia Arranz, Damian Garcia-Olmo
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Patent number: 8182816Abstract: Disclosed are methods of treating subjects having cancers including administering an effective amount of an early activation molecule agonist, antagonist or depletor, to the subject. Human monoclonal antibodies specific to the early activation molecules, and methods of use, are also disclosed.Type: GrantFiled: November 11, 2010Date of Patent: May 22, 2012Assignees: Universidad Autonoma de Madrid, Consejo Superior de Investigaciones CientificasInventors: Francisco Sanchez-Madrid, Carlos-Martinez Alonso, David Sancho Madrid, Pablo Engel Rocamora, Enric Esplugues Artola, Javier Vega Ramos, Pilar Lauzurica Gomez
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Patent number: 8066996Abstract: Antibodies, or antigen-binding fragment thereof, which bind to a CCR7 receptor are capable of selectively killing, impairing migration and/or blocking dissemination of tumor cells expressing a CCR7 receptor. Use of said antibodies for killing or for inducing apoptosis of said tumor is disclosed, thus providing an alternative therapy for treatment of cancer which tumor cells express a CCR7 receptor.Type: GrantFiled: July 5, 2006Date of Patent: November 29, 2011Assignee: Universidad Autonoma de MadridInventors: Cecilia Munoz Calleja, Manuel Jesus Alfonso Perez, Sonia Lopez Giral
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Patent number: 7993827Abstract: The present invention describes a method for the determination of DNA fragmentation in animal sperm. It particularly refers to a procedure to evaluate the integrity of the chromatin/DNA of the sperm by means of a treatment of the sample with a denaturing solution followed, optionally by a stain; a subsequent treatment with a lysis solution that does not contain a protein denaturing detergent, followed, optionally, by a stain; and an evaluation of the integrity of the chromatin/DNA. The present invention also refers to a Kit to evaluate the quality of the sperm of animals which includes a DNA denaturing solution and a lysis solution that does not contain a protein denaturing detergent.Type: GrantFiled: January 26, 2005Date of Patent: August 9, 2011Assignee: Universidad Autonoma de MadridInventors: Jaime Gosalvez Berenguer, Jose Luis Fernandez Garcia, Vicente Goyanes Villaescusa
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Publication number: 20110189345Abstract: The present invention provides an oily mixture based on natural bioactive ingredients to be used to prepare an enriched food product that includes salmon oil enriched with EPA and DHA, alpha-tocopherol and supercritical rosemary extract. Optionally, this mixture can contain the microalga Dunaliella salina. The invention also provides a food product enriched with this oily mixture based on natural bioactive ingredients. This enriched food product has great benefits for human health owing to its stable contents of polyunsaturated fatty acids with a ?-3 to ?-6 ratio lower than 5, of alpha-tocopherol, phenolic diterpenes derived from supercritical rosemary extract and, optionally, carotenoids derived from the microalga Dunaliella salina. Finally, the invention also refers to a method to prepare this enriched food product.Type: ApplicationFiled: April 14, 2011Publication date: August 4, 2011Applicants: UNIVERSIDAD AUTONOMA DE MADRID, EMBUTIDOS FRIAL, S.A.Inventors: GUILLERMO REGLERO RADA, PALOMA FRIAL SUAREZ, JAVIER SEÑORANS RODRÍGUEZ, ELENA IBAÑEZ EZEQUIEL, SUSANA SANTOYO DIEZ, CARLOS TORRES OLIVARES, LAURA JAIME DE PABLO, CRISTINA SOLER RIVÁS, MÓNICA RODRÍGUEZ GARCIA-RISCO, FRANCISCO MARÍN MARTÍN, ALEJANDRO RUIZ RODRÍGUEZ
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Patent number: 7867475Abstract: Disclosed are methods of treating subjects having disorders or conditions characterized by an unwanted immune response including administering an effective amount of an early activation molecule agonist, antagonist or depletor, to the subject. Human monoclonal antibodies specific to the early activation molecules, and methods of use, are also disclosed.Type: GrantFiled: February 2, 2004Date of Patent: January 11, 2011Assignees: Universidad Autonoma de Madrid, Consejo Superior de Investigaciones CientificasInventors: Francisco Sanchez-Madrid, Carlos Martinez Alonso, David Sancho Madrid, Pablo Engel Rocamora, Enric Esplugues Artola, Javier Vega Ramos, Pilar Lauzurica Gómez