Abstract: The present invention provides an isolated and purified protein derived from Bacillus thuringiensis subspecies thuringiensis, having a molecular weight of approximately 20 kDa of SDS-PAGE, said protein having the partial amino acid sequence shown in SEQ ID No. 1, and wherein said protein displays cytotoxic effects against tumor cells. Also provided is a method of treating a neoplastic cell comprising administering a therapeutically effective dose of the composition of the present invention to said cell, and a method of activating macrophages, comprising administering a therapeutically effective dose of the composition of the present invention to said macrophages.
Type:
Grant
Filed:
April 2, 1997
Date of Patent:
November 2, 1999
Assignees:
Research Development Foundation, Universidad Autonoma de Nievo Leon
Inventors:
Bharat B. Aggarwal, Cristina Rodriguez-Padilla