Patents Assigned to UNIVERSIDAD CATOLICA DE CORDOBA
  • Protozoan variant-specific surface proteins (VSP) as carriers for oral drug delivery
    Patent number: 9757471
    Abstract: The invention provides compositions for oral delivery and methods of treatment using VSP carriers, such as Giardia sp. variable surface proteins (VSP), to deliver therapeutic agents. VSP drug carriers can be combined with bioactive peptides, e.g., insulin, glucagon, or hGH, and be administered orally or mucosally. VSP carriers are resistant to acidic pHs and to proteolytic degradation and protect therapeutic agents from degradation in the gastrointestinal tract.
    Type: Grant
    Filed: July 5, 2013
    Date of Patent: September 12, 2017
    Assignees: UNIVERSIDAD CATOLICA DE CORDOBA, ASSISTANCE PUBLIQUE HOPITAUX DE PARIS, CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECHNICAS (CONICET), UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
    Inventors: David Klatzmann, Eliane Piaggio, Hugo Lujan
  • Modified protozoan expressing at least two variable surface proteins (VSP), a vaccine comprising it and procedures, uses, and methods thereof
    Patent number: 9463229
    Abstract: Modified protozoa parasites comprising simultaneous expression on its surface of at least two variable surface proteins (VSP). The modified protozoa may also simultaneously express the complete repertoire of variable surface proteins. Protozoa show reduced expression of Dicer, RNA-dependant RNA-polymerase (RdRP) enzymes or both, wherein the RdRP gene and/or the Dicer gene has been silenced. The protozoan may be any protozoan showing an antigenic variation mechanism.
    Type: Grant
    Filed: December 2, 2009
    Date of Patent: October 11, 2016
    Assignee: Universidad Catolica de Cordoba
    Inventor: Hugo Daniel Lujan
  • Protozoan variant-specific surface proteins (VSP) as carriers for oral drug delivery
    Patent number: 9457096
    Abstract: The invention provides compositions for oral delivery and methods of treatment using VSP carriers, such as Giardia sp. variable surface proteins (VSP), to deliver therapeutic agents. VSP drug carriers can be combined with bioactive peptides, e.g., insulin, glucagon, or hGH, and be administered orally or mucosally. VSP carriers are resistant to acidic pHs and to proteolytic degradation and protect therapeutic agents from degradation in the gastrointestinal tract.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: October 4, 2016
    Assignees: CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONCET), UNIVERSIDAD CATOLICA DE CORDOBA, ASSISTANCE PUBUQUE HOPITAUX DE PARIS, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 8)
    Inventors: David Klatzmann, Eliane Piaggio, Hugo Lujan
  • PHARMACEUTICAL COMPOSITIONS COMPRISING A POLYPEPTIDE COMPRISING AT LEAST ONE CXXC MOTIF AND HETEROLOGOUS ANTIGENS AND USES THEREOF
    Publication number: 20130095133
    Abstract: The invention relates to pharmaceutical compositions using a polypeptide comprising at least one CXXC motif, such as Giardia parasite's variable surface proteins (VSP) or a fragment thereof to raise by oral or mucosal vaccination an immune response against a heterologous selected antigen, such as tumor antigen, microbial antigen or other antigen.
    Type: Application
    Filed: March 29, 2011
    Publication date: April 18, 2013
    Applicants: INSERM (Institut National de la Sante et de la Recherche Medicale), Centre National de la Recherche Scientifique - CNRS, Universidad Catolica de Cordoba (UCC), Assistance Publique Hopitaux de Paris, Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Universite Pierre et Marie Curie (Paris 6)
    Inventors: David Klatzmann, Eliane Piaggio, Hugo Daniel Luján