Abstract: The present invention provides a Human Papillomavirus (HPV) detection method, the results capable of being read on specimen slides through in situ hybridization techniques. The method is based on a pair of consensus polynucleotide probes which hybridize type-specifically with clinically important HPV viral types and is capable of distinguishing between malignant and benign HPV viruses. Compositions of the polynucleotide probes in detectably labeled form are also a part of the invention. For correlation of the present method with known polymerase chain reaction (PCR) detection of HPV, a PCR assay is described.
Type:
Grant
Filed:
January 15, 1992
Date of Patent:
September 13, 1994
Assignees:
Cerveceria Polar, Universidad Central de Venezuela
Inventors:
Ivan Galindo-Castro, Jose L. Ramirez, Rafael R. Aldao
Abstract: A reversible adsorbent for carbon dioxide, which can be used as a decontaminant of closed environments, has been devised. It consists of a novel material formed by a surface modified silica gel with active sites for the chemisorption of CO.sub.2 at room temperature combined with a clay which acts as an agglomerant in a preferred weight ratio of 80/20. The carbon dioxide is liberated under heating at 110.degree. C. The surface area of the material ranges between about 120 and about 240 m.sup.2 /g with a total pore volume between about 0.4 and about 0.8 cc/g where about 80% of the total pore volume contains pores of a diameter between about 60 .ANG. and about 180 .ANG.. The material is capable of adsorbing between about 7.5 and 11.7 cc of dry CO.sub.2 per gram and can be regenerated between about 70.degree. and about 150.degree. C. without losing any adsorptive capacity. Dry carbon dioxide is chemisorbed as a surface ammonium carbamate which becomes a surface bicarbonate in the presence of water.
Type:
Grant
Filed:
July 19, 1990
Date of Patent:
February 11, 1992
Assignees:
Armada de la Republica de Venezuela, Universidad Central de Venezuela
Inventors:
Orlando Leal, Carmelo Bolivar, Gonzalo Sepulveda, Gregorio Molleja, German Martinez, Leon Esparragoza
Abstract: A natural active stable catalyst for use in the hydrodemetallization (HDM) and the hydroconversion (HC) of heavy crudes and residues and, in particular, a method for the preparation of the catalyst from natural clay and a process for the treatment of heavy crudes and residues with the catalyst. The catalyst is free of hydrogenating metals of Groups VIB and VIII of the Periodic Table and comprises primarily iron, silica and alumina derived from the composition of the natural clay. The catalyst possesses a surface area of between 20 to 100 m.sup.2 /g, a total pore volume of between 0.20 to 0.90 cc/g, where 50 to 100% of the total pore volume contains pores of diameter greater than 400 .ANG.. The catalyst has a ratio I(Fe)/I(Si+Al) of between 0.2 to 0.9 as determined by XPS.
Type:
Grant
Filed:
August 28, 1985
Date of Patent:
September 23, 1986
Assignees:
Intevep, S.A., Universidad Central de Venezuela
Inventors:
Gonzalo Sepulveda, Marcos Rosa-Brussin, Nereida Carrion, Pedro Roa, Alfredo Morales Ruiz, Jose Guitian, Otto Rodriguez, Carlos Zerpa
Abstract: A natural active stable catalyst for use in the hydrodemetallization (HDM) and the hydroconversion (HC) of heavy crudes and residues and, in particular, a method for the preparation of the catalyst from natural clay and a process for the treatment of heavy crudes and residues with the catalyst. The catalyst is free of hydrogenating metals of Groups VIB and VIII of the Periodic Table and comprises primarily iron, silica and alumina derived from the composition of the natural clay. The catalyst possesses a surface area of between 20 to 100 m.sup.2 /g, a total pore volume of between 0.20 to 0.90 cc/g, where 50 to 100% of the total pore volume contains pores of diameter greater than 400 .ANG.. The catalyst has a ratio I(Fe)/I(Si+Al) of between 0.2 to 0.9 as determined by XPS.
Type:
Grant
Filed:
October 3, 1984
Date of Patent:
February 4, 1986
Assignees:
Intevep, S.A., Universidad Central de Venezuela
Inventors:
Gonzalo Sepulveda, Marcos Rosa-Brussin, Nereida Carrion, Pedro Roa, Alfredo Morales Ruiz, Jose Guitian, Otto Rodriguez, Carlos Zerpa