Abstract: The present invention relates to the field of biomaterials, more particularly to the field of poly(alkyl cyanoacrylate) based nano- and microfibers. The present invention provides a novel method for producing ready-to-use poly(alkyl cyanoacrylate) based nano/microfibers, wherein the method comprises electrospinning of poly(alkyl cyanoacrylate) homopolymers or copolymers generated by anionic polymerization of alkyl cyanoacrylate monomers or oligomers and characterized by a specific polydispersity index. Accordingly, the present invention also provides novel ready-to-use nano/microfibers obtainable by the method as well as uses thereof, including (therapeutic) biomedical applications such as wound healing, drug delivery and tissue regeneration and engineering.
Type:
Application
Filed:
December 16, 2019
Publication date:
January 27, 2022
Applicants:
Charité Universitätsmedizin Berlin, Universidad De La Habana, WIWEX GmbH
Abstract: Formula III compound, its products and pharmaceutical compositions containing them for the treatment of central nervous and vascular system diseases, particularly neurodegenerative disorders with cognitive deterioration, diseases associated with oxidative stress, diseases taking in mitochondrial dysfunction, Parkinson's disease and neuropathic pain, as well as the pathological processes associated with aging.
Type:
Grant
Filed:
May 3, 2017
Date of Patent:
August 24, 2021
Assignees:
UNIVERSIDAD DE LA HABANA, CENTRO DE INVESTIGACIÓN Y DESARROLLO DE MEDICAMENTOS CIDEM
Abstract: The present invention relates to the pharmaceutics, biotechnological and chemical, and particularly to a process for preparing a composition for detecting and measuring the concentration of endotoxins or lipopolysaccharides, peptidoglycans and (1,3)-?-D-glucans, using an extract from the hemocytes of the lobster as a starting material, the changes to the composition to increase the sensitivity, and processes for measuring endotoxins, peptidoglycans and (1,3)-?-D-glucans using said composition.
Type:
Grant
Filed:
June 20, 2018
Date of Patent:
November 24, 2020
Assignees:
CENTRO DE INVESTIGACION Y DESARROLLO DE MEDICAMENTOS (CIDEM), UNIVERSIDAD DE LA HABANA
Abstract: The present invention relates to Chemistry, Pharmaceutical and in particular to the preparation of formulations from derivatives of phenolic or polyphenolic compounds and from derivatives of phenolic or polyphenolic compounds combined with tricyclic systems of the benzodiazepine type fused to derivatives of 1,4-dihydropyridines with action on the Central Nervous and Vascular Systems. These pharmaceutical compositions exhibit GABAergic, antiglutamatergic, calcium channel modulating, mitoprotective, anti-oxidant, anti-inflammatory, and antiapoptotic action, usable in the treatment of cardiovascular, cerebrovascular, neurodegenerative, neuropsychiatric and neurological diseases.
Type:
Grant
Filed:
May 3, 2017
Date of Patent:
July 28, 2020
Assignees:
UNIVERSIDAD DE LA HABANA, CENTRO DE INVESTIGACIÓN Y DESARROLLO DE MEDICAMENTOS CIDEM
Inventors:
Estael Ochoa Rodríguez, Yamila Verdecia Reyes, Yanier Núñez Figueredo, Jeney Ramírez Sánchez, Maylin Wong Guerra, Luis Arturo Fonseca Fonseca, Gilberto Lázaro Pardo Andreu, Claudia Amanda Canaán-Haden Navarro, Abel Mondelo Rodríguez, Pedro Gilberto Bárzaga Fernández, Nicté González Alfonso, René Delgado Hernández, Alejandro Saúl Padrón Yaquis
Abstract: The present invention relates to the pharmaceutics, biotechnological and chemical, and particularly to a process for preparing a composition for detecting and measuring the concentration of endotoxins or lipopolysaccharides, peptidoglycans and (1,3)-?-D-glucans, using an extract from the hemocytes of the lobster as a starting material, the changes to the composition to increase the sensitivity, and processes for measuring endotoxins, peptidoglycans and (1,3)-?-D-glucans using said composition.
Type:
Grant
Filed:
December 27, 2012
Date of Patent:
July 17, 2018
Assignees:
Centro de Investifacion Y Desarrollo de Medicament (CIDEM), Universidad de La Habana
Abstract: The present invention relates to the field of the Medicine, in particular with the chemical synthesis of oligosaccharide mixtures derived of ribose-ribitol-phosphate, which are used as active principle in vaccines for the prevention of infections caused by Haemophilus influenzae type b (Hib), as well as with the vaccines containing said oligosaccharide mixtures.
The oligasaccharide mixtures obtained by chemical synthesis of the present invention, comprise repeating units of formulae (phosphate-ribosa-ribitol)n or (ribose-ribitol-phosphate)n of at least 5 compounds of structure A or B, which represent the repeating unit of the capsular polysaccharide of Haemophilus influenzae type b and differ only by n, being n a value contained between 4 and 25 (n≧4 y≦25), and wherein R1 or R2 is a spacer for conjugation to a carrier, with the condition of R1=spacer if R2=H, or R2=spacer if R1=H.
Type:
Grant
Filed:
July 16, 2002
Date of Patent:
July 20, 2004
Assignees:
Universidad de la Habana, University of Ottawa
Inventors:
Vicente Guillermo Vérez Bencomo, Rene Roy