Abstract: A method of estimating speech intelligibility is disclosed. The method comprises the steps of providing at least a first time-dependent signal derived from a first auditory stimulus and a corresponding first measured EEG response; comparing at least part of the first signal with at least part of the first measured EEG response in order to determine a signal-response latency difference; comparing the signal-response latency difference to a reference value; and deriving a measure of speech intelligibility based on the comparison of the signal-response latency difference and the reference value.
Type:
Application
Filed:
October 2, 2020
Publication date:
February 15, 2024
Applicants:
Katholieke Universiteit Leuven, Universidad de la Republica
Inventors:
Francisco Cervantes Constantino, Tom Francart, Jonas Vanthornhout
Abstract: A method of treating obesity, preventing weight gain, reducing the rate of weight gain, and treating adverse effects related to obesity by administering SANA to induce thermogenesis in a subject.
Type:
Application
Filed:
March 29, 2023
Publication date:
November 2, 2023
Applicants:
Institut Pasteur de Montevideo, Universidad de la República
Inventors:
Carlos Batthyány, Gloria Virginia López, Carlos Escande, Jorge Rodriguez Duarte, Williams Arturo Porcal Quinta, Rosina Dapueto Capuccio, Gérman Adrian Galliussi López, Mária Pia Garat Nuñez
Abstract: The invention relates to methods for improving abiotic stress tolerance (and/or yield) in plants, including enhanced drought tolerance. It discloses nucleic acid constructs comprising the isolated polynucleotides, transgenic plants expressing the same, and methods of using the same for increasing abiotic stress tolerance (and/or yield).
Type:
Grant
Filed:
December 20, 2018
Date of Patent:
April 4, 2023
Assignees:
INSTITUTO NACIONAL DE INVESTIGACION AGROPECUARIA, UNIVERSIDAD DE LA REPUBLICA, CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS, ESTACION EXPERIMENTAL AGROINDUSTRIAL OBISPO COLOMBRES
Inventors:
Julio Omar Borsani Cambón, Esteban Casaretto De Gregorio, Juan Pablo Gallino Malcuori, Andrea Luciana Fleitas Belamendia, Maria Victoria Bonnecarrère Martinez, Atilio Pedro Castagnaro, Esteban Mariano Pardo, Sabina Vidal Macchi
Abstract: The invention comprises a device and method to estimate the elasticity of soft elastic solids from surface wave measurements. The method is non-destructive, reliable and repeatable. The final device is low-cost and portable. It is based in audio-frequency shear wave propagation in elastic soft solids. Within this frequency range, shear wavelength is centimeter sized. Thus, the experimental data is usually collected in the near-field of the source. Therefore, an inversion algorithm taking into account near-field effects was developed for use with the device. Example applications are shown in beef samples, tissue mimicking materials and in vivo skeletal muscle of healthy volunteers.
Type:
Grant
Filed:
October 30, 2018
Date of Patent:
January 24, 2023
Assignee:
UNIVERSIDAD DE LA REPUBLICA
Inventors:
Nicolás Benech, Gustavo Grinspan, Sofía Aguiar, Carlos Negreira
Abstract: Methods of treating acute and chronic inflammatory conditions, tissue transplant rejection, and/or organ transplant rejection comprising administering to a subject in need thereof a therapeutically effective amount of a pluripotent anti-inflammatory and metabolic modulators optionally in combination with one or more secondary therapeutic agents and pharmaceutical compositions thereof.
Type:
Application
Filed:
June 6, 2022
Publication date:
September 22, 2022
Applicants:
INSTITUT PASTEUR DE MONTEVIDEO, UNIVERSIDAD DE LA REPÚBLICA
Inventors:
Carlos Batthyány, Gloria Virginia López, Carlos Escande, Jorge Rodriguez Duarte, Williams Arturo Porcal Quinta, Rosina Dapueto Capuccio, Germán Adrian Galliussi López, Maria Pia Garat Nuñez, Marcelo Hill, Mercedes Segovia
Abstract: Methods of treating acute and chronic inflammatory conditions, tissue transplant rejection, and/or organ transplant rejection comprising administering to a subject in need thereof a therapeutically effective amount of a pluripotent anti-inflammatory and metabolic modulators optionally in combination with one or more secondary therapeutic agents and pharmaceutical compositions thereof.
Type:
Grant
Filed:
January 17, 2020
Date of Patent:
August 2, 2022
Assignees:
INSTITUT PASTEUR DE MONTEVIDEO, UNIVERSIDAD DE LA REPÚBLICA
Inventors:
Carlos Batthyány, Gloria Virginia López, Carlos Escande, Jorge Rodriguez Duarte, Williams Arturo Porcal Quinta, Rosina Dapueto Capuccio, Germán Adrian Galliussi López, María Pia Garat Nuñez
Abstract: A method of treating obesity, preventing weight gain, reducing the rate of weight gain, and treating adverse effects related to obesity by administering SANA to induce thermogenesis in a subject.
Type:
Application
Filed:
March 30, 2021
Publication date:
July 15, 2021
Applicants:
Institut Pasteur de Montevideo, Universidad de la República
Inventors:
Carlos Batthyány, Gloria Virginia López, Carlos Escande, Jorge Rodriguez Duarte, Williams Arturo Porcal Quinta, Rosina Dapueto Capuccio, Gérman Adrian Galliussi López, Mária Pia Garat Nuñez
Abstract: This invention relates to the use of nitroalkene derivatives for the treatment of neurodegenerative conditions in mammals in which neuroinflammation is a contributing factor, such as in amyotrophic lateral sclerosis (ALS).
Type:
Application
Filed:
October 26, 2020
Publication date:
April 29, 2021
Applicants:
Institut Pasteur de Montevideo, Universidad de la República
Inventors:
Luis Barbeito, Emiliano Trías, Sofía Ibarburu, Carlos Batthyány, Carlos Escande, Gloria Virginia López, Williams Arturo Porcal Quinta, Mariana Ingold, Lucia Colella
Abstract: Nitroalkene non-steroidal anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of treating inflammation related conditions.
Type:
Application
Filed:
December 23, 2020
Publication date:
April 15, 2021
Applicants:
Institut Pasteur de Montevideo, Universidad de la República
Inventors:
Carlos Batthyány, Gloria Virginia López, Carlos Escande, Jorge Rodriguez Duarte, Williams Arturo Porcal Quinta, Rosina Dapueto Capuccio, Germán Adrian Galliussi López, María Pia Garat Nuñez, Paulina Invernizzi, Mariana Ingold, Lucia Colella
Abstract: Nitroalkene non-steroidal anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of treating inflammation related conditions.
Type:
Grant
Filed:
August 7, 2019
Date of Patent:
February 2, 2021
Assignees:
INSTITUT PASTEUR DE MONTEVIDEO, UNIVERSIDAD DE LA REPUBLICA
Inventors:
Carlos Batthyány, Gloria Virginia López, Carlos Escande, Jorge Rodriguez Duarte, Williams Arturo Porcal Quinta, Rosina Dapueto Capuccio, Germán Adrian Galliussi López, María Pia Garat Nuñez, Paulina Invernizzi, Mariana Ingold, Lucia Colella
Abstract: A method of treating obesity, preventing weight gain, reducing the rate of weight gain, and treating adverse effects related to obesity by administering SANA to induce thermogenesis in a subject.
Type:
Application
Filed:
September 20, 2019
Publication date:
May 21, 2020
Applicants:
Institut Pasteur de Montevideo, Universidad de la República
Inventors:
Carlos Batthyány, Gloria Virginia López, Carlos Escande, Jorge Rodriguez Duarte, Williams Arturo Porcal Quinta, Rosina Dapueto Capuccio, Germán Adrian Galliussi López, María Pia Garat Nuñez
Abstract: Methods of treating acute and chronic inflammatory conditions, tissue transplant rejection, and/or organ transplant rejection comprising administering to a subject in need thereof a therapeutically effective amount of a pluripotent anti-inflammatory and metabolic modulators optionally in combination with one or more secondary therapeutic agents and pharmaceutical compositions thereof.
Type:
Application
Filed:
January 17, 2020
Publication date:
May 14, 2020
Applicants:
Institut Pasteur de Montevideo, Universidad de la República
Inventors:
Carlos Batthyány, Gloria Virginia López, Carlos Escande, Jorge Rodriguez Duarte, Williams Arturo Porcal Quinta, Rosina Dapueto Capuccio, Germán Adrian Galliussi López, María Pia Garat Nuñez, Marcelo Hill, Mercedes Segovia
Abstract: Methods of treating acute and chronic inflammatory conditions, tissue transplant rejection, and/or organ transplant rejection comprising administering to a subject in need thereof a therapeutically effective amount of a pluripotent anti-inflammatory and metabolic modulators optionally in combination with one or more secondary therapeutic agents and pharmaceutical compositions thereof.
Type:
Grant
Filed:
October 16, 2017
Date of Patent:
January 21, 2020
Assignees:
Institut Pasteur de Montevideo, Universidad de la República
Inventors:
Carlos Batthyány, Gloria Virginia López, Carlos Escande, Jorge Rodriguez Duarte, Williams Arturo Porcal Quinta, Rosina Dapueto Capuccio, Germán Adrian Galliussi López, María Pia Garat Nuñez, Marcelo Hill, Mercedes Segovia
Abstract: Nitroalkene non-steroidal anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of treating inflammation related conditions.
Type:
Application
Filed:
August 7, 2019
Publication date:
November 28, 2019
Applicants:
Institut Pasteur de Montevideo, Universidad de la República
Inventors:
Carlos Batthyány, Gloria Virginia López, Carlos Escande, Jorge Rodriguez Duarte, Williams Arturo Porcal Quinta, Rosina Dapueto Capuccio, Germán Adrian Galliussi López, María Pia Garat Nuñez, Paulina Invernizzi, Mariana Ingold, Lucia Colella
Abstract: Nitroalkene non-steroidal anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of treating inflammation related conditions.
Type:
Application
Filed:
December 27, 2017
Publication date:
June 27, 2019
Applicants:
Institut Pasteur de Montevideo, Universidad de la República
Inventors:
Carlos Batthyány, Gloria Virginia López, Carlos Escande, Jorge Rodriguez Duarte, Williams Arturo Porcal Quinta, Rosina Dapueto Capuccio, Germán Adrian Galliussi López, María Pia Garat Nuñez, Paulina Invernizzi, Mariana Ingold, Lucia Colella
Abstract: Methods of treating acute and chronic inflammatory conditions, tissue transplant rejection, and/or organ transplant rejection comprising administering to a subject in need thereof a therapeutically effective amount of a pluripotent anti-inflammatory and metabolic modulators optionally in combination with one or more secondary therapeutic agents and pharmaceutical compositions thereof.
Type:
Application
Filed:
October 16, 2017
Publication date:
April 19, 2018
Applicants:
Institut Pasteur de Montevideo, Universidad de la República
Inventors:
Carlos Batthyány, Gloria Virginia López, Carlos Escande, Jorge Rodriguez Duarte, Williams Arturo Porcal Quinta, Rosina Dapueto Capuccio, Germán Adrian Galliussi López, María Pia Garat Nuñez, Marcelo Hill, Mercedes Segovia
Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of bacterial infections. In particular, the present invention relates to a Toll-like receptor (TLR) agonist for use in a method for the treatment of a bacterial infection in a subject in need thereof wherein the TLR agonist is administered to the subject in combination with at least one antibiotic.
Type:
Grant
Filed:
July 25, 2014
Date of Patent:
March 20, 2018
Assignees:
INSERM (Institut National de la Sante et de la Recherche Medicale), Universite de Droit et de la Sante de Lille 2, Centre National de la Recherche Scientifique (CNRS), Institut Pasteur de Lille, Universite de Lille 1 Sciences et Technologies, ETH Zurich, Universidad de la Republica
Inventors:
Wolf-Dietrich Hardt, Patrick Kaiser, Jean-Claude Sirard, Christophe Carnoy, Delphine Fougeron, Jose Alejandro Chabalgoity, Natalia Munoz
Abstract: The present invention describes that neurotrophins undergo post-translational modifications, and that these post-translational modifications mediate the pro-apoptotic and/or pro-neurite activity of neurotrophins. These post-translational modifications notably include nitration and the formation of conformationally-different dimers, as well as of abnormal oligomers, such as tetramers and octamers. The invention further relates to compounds that compete with such modified neurotrophins, as well as to compounds that bind to these modified neurotrophins. The invention thus provides useful agents for the treatment of the conditions or diseases involving chronic pain and/or neuron loss.
Type:
Grant
Filed:
September 26, 2013
Date of Patent:
May 3, 2016
Assignees:
INSTITUT PASTEUR, INSTITUTO DE INVESTIGACIONES BIOLOGICAS CLEMENTE ESTABLE, FACULTAD DE MEDICINA, UNIVERSIDAD DE LA REPUBLICA, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
Inventors:
Luis Barbeito, Mariana Pehar, Patricia Cassina, Pedro M. Alzari
Abstract: The invention relates to the composition, preparation and use of a formulation as an adjuvant for human or animal use, said formulation comprising at least one bile acid or salts thereof and saponin, in order to enhance the immune response against an antigen, which may or may not be well defined, including but not limited to bacterins, antigens and antigenic preparations that are viral, bacterial or parasitic, and antigens associated with diseases such as different types of cancer. The antigens used can be isolated from pathogens, as well as products resulting from enzymatic or chemical modification, synthetic or recombinant antigens, or mixtures of the same.
Type:
Application
Filed:
December 9, 2013
Publication date:
November 5, 2015
Applicant:
UNIVERSIDAD DE LA REPUBLICA DE URUGUAY
Inventors:
Fernando Amaury FERREIRA CHIESA, Leonora QUIRICI VALADAN, Maria Ines BESSIO PRATO, Luis Fernando SILVEIRA GONZALEZ
Abstract: Compounds derived from imidazo[4,5-c][1,2,6]thiadiazine 2,2-dioxides, for use as a drug or pharmaceutical composition for treatment of parasitic diseases, preferably of diseases caused by parasites of the Trypanosoma genus, and more preferably for treatment of the Chagas disease. Furthermore, the invention also relates to the pharmaceutical compositions comprising said compounds.
Type:
Grant
Filed:
January 26, 2010
Date of Patent:
August 26, 2014
Assignees:
Universidad de la Republica de Uruguay, Consejo Superior de Investigaciones Cientificas
Inventors:
Juan Antonio Paez Prosper, Nuria Eugenia Campillo Martín, Ángela Guerra Álvarez, Maria Mercedes González Hormaizteguy, Hugo Cerecetto Meyer